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| 1 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 2 | To stay or to leave: Stem cells and progenitor cells navigating the S1P gradient显示文摘Most hematopoietic stem progenitor cells (HSPCs) reside in bone marrow (BM), but a small amount of HSPCs have been found to circulate between BM and tissues through blood and lymph. Several lines of evidence suggest that sphingosine-1-phosphate (S1P) gradient triggers HSPC egression to blood circulation after mobilization from BM stem cell niches. Stem cells also visit certain tissues. After a temporary 36 h short stay in local tissues, HSPCs go to lymph in response to S1P gradient between lymph and tissue and eventually enter the blood circulation. S1P also has a role in the guidance of the primitive HSPCs homing to BM in vivo, as S1P analogue FTY720 treatment can improve HSPC BM homing and engraftment. In stress conditions, various stem cells or progenitor cells can be attracted to local injured tissues and participate in local tissue cell differentiation and tissue rebuilding through modulation the expression level of S1P1, S1P2 or S1P3 receptors. Hence, S1P is important for stem cells circulation in blood system to accomplish its role in body surveillance and injury recovery. | Andrew Hsu Jen-Fu Lee Daniel E Cramer Menq-Jer Lee | 2011 | World Journal of Biological Chemistry2011，2，1： | 3 |
| 3 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 4 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 5 | Efficacy of transient elastography in screening for large esophageal varices in patients with suspicious or proven liver cirrhosis显示文摘 | Huay‐Min WANG Gin‐Ho LO Wen‐Chi CHEN Ping‐I HSU Hsien‐Chung YU Chiun‐Ku LIN Hoi‐Hung CHAN Wei‐Lun TSAI Feng‐Woei TSAY Tsan‐Ping LIU E‐Ming WANG Kwok‐Hung LAI | 2012 | Journal of Digestive Diseases2012，，8： | 2 |
| 6 | Longitudinal cohort analysis of lethal prostate cancer progression in transgenic mice 显示文摘 | Hsu C X Ross B D Chrisp C E | 1998 | J Urol1998，160，4： | 1 |
| 7 | Genetic analysis of organ fusion in Arabidopsis thaliana显示文摘 | LOLLE S J HSU W PRUITT R E | 1998 | Genetics1998，149，2： | 1 |
| 8 | Lymphoepithelioma-like Cholangiocarcinoma (LELCA) not Associated with Epstein-Barr Virus显示文摘 | Szekely E Jeng YM Hsu HC | 2001 | Am J Surg Pathol2001，25，： | 1 |
| 9 | Ischemic preconditioning in the intact rat heart is mediated by deltal but not mu-or kappa-opioid receptors显示文摘 | Schultz J E Hsu A K Gross G J | 1998 | Circulation1998，97，13： | 1 |
| 10 | CDw150(SLAM) is a receptor for lymphotropic strains of measles virus and may account for the immunosuppressive properties of this virus显示文摘 | Hsu E C Iorio C Sarangi F | 2001 | Virology2001，279，： | 1 |
| 11 | Dynamics of pH in Controlled Stirred Tank reactor显示文摘 | McAvoy T J Hsu E Lowenthal S | 1972 | Ind Eng Chem Process Des1972，11，1： | 1 |
| 12 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 13 | Cubic AgPb, SbTez+,, : bulk thermoelectric materials with high figure of merit 显示文摘 | Hsu K F Loo S Guo F Chen W Dyck J S Uher C Hogan T Polychroniadis E K Kanatzidis M G | 2004 | Science2004，303，： | 1 |
| 14 | CDl50(SLAM)is a receptor for lymphotropic stain of measles virus and may account for the immunosuppressive properties of this virus显示文摘 | Hsu E C Iorio C Sarangi F | 2001 | Virology2001，279，1： | 1 |
| 15 | Anti-inflammatory activity of soy and tea in prostate cancer prevention显示文摘 | Hsu A Bray T M So E | 2010 | Exp Biol Med2010，235，6： | 1 |
| 16 | Altered expression of glutamate transporters under hypoxic conditions in vitro显示文摘 | Hsu L Rockenstein E Mallory M | 2001 | J Neurosci Res2001，64，： | 1 |
| 17 | Preparation and properties of monodispersed colloidal particles of lanthanide compounds显示文摘 | E Matuevic W P Hsu | 1987 | Journal of Colloidal and Interface Science1987，118，2： | 1 |
| 18 | Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts 显示文摘 | GROSS E R HSU A K GROSS G J | 2004 | Circ Res2004，94，7： | 1 |
| 19 | Dynamic analysis of gear-rotor system with viscoelastic supports under residual shaft bow effect 显示文摘 | Kang C H Hsu W C Lee E K | 2011 | Mechanism and Machine Theory2011，46，3： | 1 |
| 20 | The effect of deposi- tion temperature on the properties of TiN diffusion barriers prepared by atomic layer chemical vapor deposition 显示文摘 | CHENG H E LEE W J HSU C M | 2005 | Thin Solid Films2005，485，： | 1 |
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