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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | The yeast nucleoporin Nup53p specifically interacts with Nic96p and is directly involved in nuclear protein import显示文摘 | Fahrenkrog B Hubner W Mandinova A | 2000 | Mol Biol Cell2000，11，： | 1 |
| 3 | Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial显示文摘 | Susan J Dutton David R Ferry Jane M Blazeby Haider Abbas Asa Dahle-Smith Wasat Mansoor Joyce Thompson Mark Harrison Anirban Chatterjee Stephen Falk Angel Garcia-Alonso David W Fyfe Richard A Hubner Tina Gamble Lynnda Peachey Mina Davoudianfar Sarah R Pear | 2014 | Lancet Oncology2014，，8： | 1 |
| 4 | Natural history and current concepts for the treatment of small ureteral ealculi显示文摘 | HUBNER W A IRBY P STOLLER M L | 1993 | Eur Urol1993，24，： | 1 |
| 5 | Ad- justable bulbourethral male sling: experience after 101 cases of moderate-to severe male stress urinary inconti nence显示文摘 | Hubner W A Gallistl H Rutkowski M | 2011 | BJU Int2011，107，： | 1 |
| 6 | Impact of biliary stent-related events in patients diagnosed with advanced pancreatobiliary tumours receiving palliative chemotherapy显示文摘AIM: To determine the impact(morbidity/mortality) of biliary stent-related events(SRE)(cholangitis or stent obstruction) in chemotherapy-treated pancreaticobiliary patients.METHODS: All consecutive patients with advanced pancreatobiliary cancer and a biliary stent in-situ prior to starting palliative chemotherapy were identified retrospectively from local electronic case-note records(Jan 13 to Jan 15). The primary end-point was SRE rate and the time-to-SRE(defined as time from first stenting before chemotherapy to date of SRE). Progressionfree survival and overall survival were measured from the time of starting chemotherapy. Kaplan-Meier, Cox and Fine-Gray regression(univariate and multivariable) analyses were employed, as appropriate. For the analysis of time-to-SRE, death was considered as a competing event.RESULTS: Ninety-six out of 693 screened patients were eligible; 89% had a metal stent(the remainder were plastic). The median time of follow-up was 9.6 mo(range 2.2 to 26.4). Forty-one patients(43%)developed a SRE during follow-up [cholangitis(39%), stent obstruction(29%), both(32%)]. There were no significant differences in baseline characteristics between the SRE group and no-SRE groups. Recorded SRE-consequences were: none(37%), chemotherapy delay(24%), discontinuation(17%) and death(22%). The median time-to-SRE was 4.4 mo(95%CI: 3.6-5.5). Patients with severe comorbidities(P < 0.001) and patients with ≥ 2 baseline stents/biliary procedures [HR = 2.3(95%CI: 1.2-4.44), P = 0.010] had a shorter time-to-SRE on multivariable analysis. Stage was an independent prognostic factor for overall survival(P = 0.029) in the multivariable analysis adjusted for primary tumour site, performance status and development of SRE(SRE group vs no-SRE group).CONCLUSION: SREs are common and impact on patient's morbidity. Our results highlight the need for prospective studies exploring the role of prophylactic strategies to prevent/delay SREs. | Angela Lamarca Christina Rigby Mairéad G Mc Namara Richard A Hubner Juan W Valle | 2016 | World Journal of Gastroenterology2016，22，26： | 1 |
| 7 | Natural history and current concepts for the treatment of small ureteral cal- culi显示文摘 | Hubner W A Irby P Stoller M L | 1993 | Eur Urol1993，2，2： | 1 |
| 8 | Natural history and current concepts for the treatment of small ureteral calculi显示文摘 | Hubner W A Irby P Stoller M L | 1993 | Eur Urol1993，24，2： | 1 |
| 9 | 显示文摘 | Lalvani S B Hubner A W iltow ski TS | 2000 | Energy Sources2000，22，1： | 1 |
| 10 | Hysteresis and transition in swirling nonpremixed flames 显示文摘 | Tummers M J Hubner A W van Veen E H | 2009 | Combustion andFlame2009，156，2： | 1 |
| 11 | Natural history and current concepts for the treatment of small ureteral calculi显示文摘 | Hubner W A Irby P Stoller M L | 1993 | Eur Urol1993，24，2： | 1 |
| 12 | Hysteresis and transition in swirling nonpremixed flames 显示文摘 | TUMMERS M J HUBNER A W VEEN E H | 2009 | Combustion and Flame2009，156，2： | 1 |
| 13 | Laparoscopic nephropexy using tension-free vaginal tape for symptomatic nephroptosis显示文摘 | Hubner W A Schlarp O Riedl C | 2004 | Urology2004，64，： | 1 |
| 14 | Experiments on a ro-tating-pipe swirl burner显示文摘 | Hubner A W Tummers M J Hanjali K | 2003 | Experimental Thermal and Fluid Sci-ence2003，27，4： | 1 |
| 15 | Natural history and current concepts for the treatment of small ureteral calculi显示文摘 | HUBNER W A IRBY P STOLLER M L | 1993 | Eur Urol1993，24，2： | 1 |
| 16 | The double-J ureteral stent: in vivo and in vitro flow stud- ies显示文摘 | HUBNER W A PLAS E G STOLLER M L | 1992 | J Urol1992，148，21： | 1 |
| 17 | Phase stability of A1SI 304 stainless steel during sliding wear at extremely low temperature 显示文摘 | W Hubner A Pyzalla K Assmus | 2003 | Wear2003，255，： | 1 |
| 18 | Interactions at the lipid-water interface 显示文摘 | Hubner W Blume A | 1998 | Chemistry and Physics of Lipids1998，96，12： | 1 |
| 19 | Removal of hexavalew chromium and metal cations by a selective and novel carbon absorbent 显示文摘 | Lalvani S B Hubner A W iltow ski T S | 1998 | Energy Sources1998，36，7： | 1 |
| 20 | Magnetoerystalline anisotropy energy of transition-metal thin films:a nonperturbative theory显示文摘 | Lessard A Moos T H Hubner W | 1997 | Phys Rev B1997，56，5： | 1 |
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