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| 1 | Regulation of spermatogenesis by paracrine/autocrine testicular factors显示文摘Spermatogenesis is a complex process regulated by endocrine and testicular paracrine/autocrine factors.Gonadotropins are involved in the regulation of several testicular paracrine factors, mainly of the IL-1 family and testicular hormones. Testicular cytokines and growth factors (such as IL-1, IL-6, TNF, IFN-T, LIF and SCF) were shown to affect both the germ cell proliferation and the Leydig and Sertoli cells functions and secretion. Cytokines and growth factors are produced by immune cells and in the interstitial and seminiferous tubular compartments by various testicular cells, including Sertoli, Leydig, peritubular cells, spermatogonia, differentiated spermatogonia and even spermatozoa. Corresponding cytokine and growth factor receptors were demonstrated on some of the testicular cells. These cytokines also control the secretion of the gonadotropins and testosterone in the testis. Under pathological conditions the levels of pro-inflammatory cytokines are increased and negatively affected spermatogenesis. Thus,the expression levels and the mechanisms involved in the regulation of testicular paracrine/autocrine factors should be considered in future therapeutic strategies for male infertility. (Asian J Androl 2004 Sep; 6: 259-268) | Mahmoud Huleihel Eitan Lunenfeld | 2004 | Asian Journal of Andrology2004，6，3： | 22 |
| 2 | Differentiation of murine male germ cells to spermatozoa n a soft agar culture system显示文摘建立一在里面允许阴囊的细菌房间的发展到精子的 vitro 系统将为男不孕为精子发生和未来治疗的研究是珍贵的。在现在的学习,我们用三维的琼脂文化系统(囊) 处于 vitro 文化条件发展了,它有能力导致阴囊的细菌房间到达精子发生的最后的阶段,包括精子产生。从 7-day-old 老鼠的睾丸的生精的小管酶地被分裂,并且 intratubular 房间在在与胎儿的小牛浆液(FCS ) 补充的 RPMI 媒介的 SACS 的上面的层是有教养的。SACS 的更低的层包含了与 FCS 补充的仅仅 RPMI 媒介。在上面的层的殖民地在文化的 14 和 28 天以后被孤立并且根据他们的尺寸被分类。Immunofluorescence 和即时 PCR 被用来分析在无差别、区分的 spermatogonia 表示的特定的标记(Vasa, Dazl, OCT-4, C 工具包, GFR-α -1, CD9 和 α -6-integrin), meiotic 房间(LDH, Crem-1 和议会) 和 post-meiotic 房间(Protamine-1,精子酵素和 SP-10 ) 。我们的结果表明导致老鼠是可能的阴囊的 pre-meiotic 细菌房间扩大并且在囊导致他们的区别到精子。精子显示出正常形态学并且包含了 acrosomes。因此,我们的结果证明囊能为 pre-meiotic 鼠标细菌房间的成熟在 vitro 系统被用作一篇小说到 post-meiotic 阶段和词法上正常的精子。 | Mahmoud Abu Elhija Eitan Lunenfeld Stefan Schlatt Mahmoud Huleihel | 2012 | Asian Journal of Andrology2012，14，2： | 14 |
| 3 | Application of three-dimensional culture systems to study mammalian spermatogenesis, with an emphasis on the rhesus monkey (Macaca mulatta)显示文摘 | Mahmoud Huleihel Seyedmehdi Nourashrafeddin Tony M Plant | 2015 | Asian Journal of Andrology2015，17，6： | 6 |
| 4 | Functional changes after prenatal opiate exposure related to opiate receptors' regulated aherations in cholinergic innervation 显示文摘 | Yanai J Huleihel R Izrael M | 2003 | Inter J Neuropsychopharmacolog2003，6，： | 1 |
| 5 | Anti - viral activity, of red microalgal polysaccharides against retrovims显示文摘 | Marina M Talyshinsky Yelena Y Souprun Mahmoud M Huleihel | 2002 | Caner Cell Int2002，2，： | 1 |
| 6 | Optimal adaptive waveform design for cognitive MIMO radar显示文摘 | HULEIHEL W TABRIKAIN J and SHAVIT R | 2013 | IEEE Transactions on Signal Processing2013，61，20： | 1 |
| 7 | Intrauterine infection/in- flammation during pregnancy and offspring brain damages: possible mechanisms involved 显示文摘 | Huleihel M Golan H Hallak M | 2004 | Reprod Biol Endocrinol2004，2，： | 1 |
| 8 | Aging mesenchymal stem cells fail to protect because of impaired migration and antiinflammatory response 显示文摘 | Bustos ML Huleihel L Kapetanaki MG | 2014 | Am J Respir Crit Care Med2014，189，7： | 1 |
| 9 | Serum inhibin A, VEGF and TNF alpha levels after triggering oocyte maturation with HCG in women with polycystic ovaries undergoing IVF treatment: a prospective randomized trial 显示文摘 | Babayof R Margalioth E J Huleihel M | 2006 | Hum Reprod2006，21，5： | 1 |
| 10 | Antiviral effect of red microalgal polysaccharides on Herpes simplex and Varicella zoster viruses 显示文摘 | HULEIHEL M ISHANU V TAL J | 2001 | Journal of Applied Phycology2001，13，2： | 1 |
| 11 | Serum inhibin A, VEGF and TNFalpha levels after triggering oocyte maturation with GnRH agonist compared with HCG in women with polycystic ovaries undergoing IVF treatment: a prospective randomized trial显示文摘 | Babayof R Margalioth EJ Huleihel M | 2006 | Hum Reprod2006，21，： | 1 |
| 12 | Optimal adaptive waveform design for cognitive MIMO radar显示文摘 | Huleihel W Tabrikian J and Shavit R | 2013 | IEEE Transactions on Signal Processing2013，61，20： | 1 |
| 13 | Antiviral effect of red microalgal polysaccharides on Herpes simplex and Varicella zoster viruses显示文摘 | Huleihel M Ishanu V | 2001 | J Appl Phycol2001，13，2： | 1 |
| 14 | Involvement of serum and lipopolysaccharide in the production of interleukin-1-and interleukin-6-like molecules by human sperm cells显示文摘 | Huleihel M Lunenfeld E Horowitz S | 2000 | Am J Reprod Immunol2000，43，1： | 1 |
| 15 | Expression of IL-12,IL-10,PGE2,slL-2R and sIL-6R in seminal plasma of fertile and infertile men显示文摘 | LUNENFELD E HOROWITZ S | 1999 | Andrologia1999，31，5： | 1 |
| 16 | Anti-viral activity of red microalgal polysaccharides against retroviruses 显示文摘 | Marina M Talyshinsky Yelena Y Souprun Mahmoud M Huleihel | 2002 | Cancer Cell Int2002，2，1： | 1 |
| 17 | Psychological factors correlate meaningfully with percent-monocytes among acute coronary syndrome patients显示文摘 | Yori Gidron Tikva Armon Harel Gilutz Mahmoud Huleihel | 2003 | Brain Behavior and Immunity2003，，4： | 1 |
| 18 | Spec- troscopic evaluation of the effect of a red microalgal polysaccharide on herpes-infected Vero cells显示文摘 | Huleihel M Talyshinsky M Souprun Y | 2003 | Appl Spectrosc2003，57，4： | 1 |
| 19 | Serum inhibin A, VEGF and TNFalpha levels after triggering oocyte maturation with GnRH agonist compared with HCG in women with polycystie ovaries undergoing IVF treatment: a prospective randomized trial显示文摘 | Babayof R Margalioth E J Huleihel M | 2006 | Hum Reprod2006，21，5： | 1 |
| 20 | Disruption of the development of cholinergic- induced translocation/activation of PKC isoforms after prenatal heroin exposure 显示文摘 | Huleihel R Yanai J | 2006 | Brain Res Bull2006，3169，2： | 1 |
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