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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Molecular cloning and nucleotide sequence of the alphatoxin (phospholipase c) of Clostridium perfringens 显示文摘 | HUNTER S E C MARTIN K L | 1989 | Infect Immun1989，57，2： | 1 |
| 3 | Optimum preventive maintenance policies显示文摘 | Barlow R E Hunter L C | 1960 | Operation Research1960，8，： | 1 |
| 4 | Relative and absolute quantitative expression profiling of cytochromes P450 using isotope- coded affinity tags 显示文摘 | Jenkins R E Kitteringham N R Hunter C L | 2006 | Preteomics2006，6，： | 1 |
| 5 | Intrauterine growth restriction: identification and management显示文摘 | Peleg D Kennedy C M Hunter S L | 1998 | Am Fam Physician1998，58，2： | 1 |
| 6 | Differential transcriptional activity of plant-pathogenic begomoviruses in their whitefly vector (Bemisia tabaci,Gennadius:Hemiptera Aleyrodidae)显示文摘 | Sinisterra X H McKenzie C L Hunter W B Powell C A Shatters Jr.R G | | 0，，： | 1 |
| 7 | Assessment of the role of alpha2 adrenoeeptor subtypes in the antinociceptive,sedative and hypothermic action of dexmedetomictine in transgenic mice显示文摘 | Hunter J C Fontana D J Hedley L R | 1997 | Br J Pharmacol1997，122，7： | 1 |
| 8 | Human body model ac- quisition and tracking using voxel data显示文摘 | Miki'c l Trivedi M Hunter E | 2003 | International Jour- nal of Computer Vision2003，53，3： | 1 |
| 9 | Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells显示文摘 | Hunter M C O’Hagan K L Kenyon A | 2014 | PLoS One2014，9，86： | 1 |
| 10 | Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation显示文摘 | CHOY J C HUNG V H HUNTER A L | 2004 | Arterioscler Thromb Vasc Biol2004，24，： | 1 |
| 11 | Molecular cloning and nucleotide sequence of the alphatoxin of Clostridium perfrigens 显示文摘 | Tithall R W Hunter S E C Martin K L | 1989 | Infection and Immunity1989，57，2： | 1 |
| 12 | Histochemical demonstration of enzymes separated by zone electrophoresis in starch gels显示文摘 | Hunter R L Markert C L | 1957 | Science1957，125，： | 1 |
| 13 | Shape-shifting corals: Molecular markers show morphology is evolutionarily plastic in Porites 显示文摘 | Forsman Z H Barshis D J Hunter C L | 2009 | BMC Evol Biol2009，9，1： | 1 |
| 14 | Response Surface Models for Efficient, Modular Estimation of Solder Joint Reliability in Area Array Packages显示文摘 | Zhang L Subbarayan G Hunter B C Rose D | 2005 | Microelectronics Reliability2005，，： | 1 |
| 15 | Volatile constituents of litchi显示文摘 | JOHNSTON J C WELCH R C HUNTER G L K | 1980 | J Agric Food Chem1980，28，： | 1 |
| 16 | Electrostatic control of aromatic stacking interactions 显示文摘 | COCKROFT S L HUNTER C A LAWSON K R | 2005 | Journal of American Chemical SoCiety2005，127，24： | 1 |
| 17 | The effects of dexmedetomidine on regional cerebral blood flow and oxygen consumption during severe hemorrhagic hypotension in rats 显示文摘 | Hunter C Xia L Harvey R | 2011 | Anesth Analg2011，113，2： | 1 |
| 18 | Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells显示文摘 | Jagannath C Lindsey D R Dhandayuthapani S Xu Y Hunter R L Jr Eissa N T | 2009 | Nat Med2009，15，： | 1 |
| 19 | Modulation of innate immunity by Toxo- plasma gondii virulence effectors 显示文摘 | Hunter C A Sibley L D | 2012 | Nat Rev Microbiol2012，10，11： | 1 |
| 20 | Fractal cracking of concrete: parameterization of spatial diffusion显示文摘 | Addison P S McKenzie W M C Ndumu A S Dougan L T Hunter R | 1999 | Journal of Engineering Mechanics1999，125，6： | 1 |
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