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| 1 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 2 | Mitogen-activated protein kinase kinase inhibitor PD98059 blocks the trans-activation but not the stabilization or DNA binding ability of hypoxia-inducible factor-1alpha显示文摘 | Hur E Chang KY Lee E | 2001 | Mol Pharmacology2001，59，5： | 1 |
| 3 | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome 显示文摘 | Ginestier C Hur MH CharafeJanffret E | 2007 | Cell Stem Ce112007，1，5： | 1 |
| 4 | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor elinical outcome显示文摘 | Ginestier C Hur MH Charafe-Jauffret E | 2007 | Cell Stem Cell2007，1，5： | 1 |
| 5 | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome显示文摘 | Ginestier C Hur MH Charafe-Jauffret E | | 0，，05： | 1 |
| 6 | Monitoring of selected veterinary antibiotics in environmental compartments near a composting facility in Gangwon Province,Korea显示文摘 | Ok Y S Kim S C Kim K R Lee S S Moon D H Lim K J Sung J K Hur S O Yang J E | | 0，，： | 1 |
| 7 | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome显示文摘 | GINESTIER C HUR M H CHARAFE-JAUFFRET E | 2007 | Cell Stem Cell2007，1，5： | 1 |
| 8 | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome显示文摘 | Ginestier C Hur MH Charfe-Jauffret E | 2007 | Cell Stem Cell2007，1，5： | 1 |
| 9 | ALDH1 is a marker of normal and malignant breast stem cells and a predictor of poor clinical outcome显示文摘 | Ginestier C Hur M Charafe-Jauffret E | 2007 | Cell Stem Cell2007，1，5： | 1 |
| 10 | ALDH1 is a mar- ker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome显示文摘 | Ginestier C Hur MH Charafe-Jauffret E | 2007 | Cell Stem Cell2007，1，5： | 1 |
| 11 | Transition state stabilization bygeneral acid catalysis, water expulsion, and enzyme reorgani-zation in Medicago savita chalcone isomerase 显示文摘 | Hur S Newby Z E Bruice T C | 2004 | Proc NatlAcad Sci2004，101，9： | 1 |
| 12 | ALDH1 is amarker of normal and malignant human mammary stem cellsand a predictor of poor clinical outcome显示文摘 | Ginestier C Hur M H Charafe-Jauffret E | 2007 | Cell Stem Cell2007，1，5： | 1 |
| 13 | The effect of fluoride on binding and photodynamic action of phthalocyanines with proteins显示文摘 | Ben Hur E Dubblelman TM van Steveninck J | 1991 | Photochem Photobiol1991，54，5： | 1 |
| 14 | ALDH1 is a marker of normal and malignant human nlalilmary stem cells and a predic- tor of poor clinical outcome 显示文摘 | Ginestier C Hur M H Charafe Jauffret E el al | 2007 | Cell Stem cell2007，1，5： | 1 |
| 15 | Ethanol extract of propolis inhibits nitric oxide synthase gene expression and enzyme activity 显示文摘 | Song Y S Park E H Hur G M | 2002 | J Ethnopharmacol2002，80，23： | 1 |
| 16 | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome显示文摘 | Ginestier C Hur MH Charafe Jauffret E | 2007 | Cell Stem Cell2007，1，5： | 1 |
| 17 | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome显示文摘 | Ginestier C Hur M H Charafe-Jauffret E | 2007 | Cell Stem Cell2007，1，5： | 1 |
| 18 | ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome显示文摘 | Ginestier C Hur MH Charafe-Jauffret E | 2007 | Cell Stem Cell2007，1，： | 1 |
| 19 | NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF- 1alpha显示文摘 | Kim T H Hur E G Kang S J | 2011 | Cancer Res2011，71，6： | 1 |
| 20 | ALDH1 is a markerof normal and malignant human mammary stem cells and a predictorof poor clinical outcome显示文摘 | Ginestier C Hur MH Charafe-Jauffret E | 2007 | Cell Stem Cell2007，1，5： | 1 |
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