|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Method Development of Enantiomer Separations by Affinity Capillary Electrophoresis,Cyclodextrin Electrokinetic Chromatography and Capillary Electrophoresis-Mass Spectrometry显示文摘Capillary electrophoresis (CE) has become a powerful tool for enantiomer separations during the last decade. Since 1993, the author has investigated enantiomer separations by affinity capillary electrophoresis (affinity CE) with some proteins and by cyclodextrin electrokinetic chromatography (CDEKC) with some charged cyclodextrins (CDs). Many successful enantiomer separations are demonstrated from our study in this review article. In the enantiomer separations by affinity CE, the deterioration of detection sensitivity was observed under high concentration of the protein in running solutions. The partial filling technique was practically useful to solve the serious problem. It allowed operation at high protein concentrations, such as 500 μmol/L, without the detection problem. Charged CDs had several advantages for the enantiomer separations over neutral ones. Strong electrostatic interactions between a charged CD and oppositely charged analytes should be effective for the formation of the complex. A large difference in electrophoretic mobility between the free analyte and the inclusion complex should also enhance the enantiomeric resolution. In CE mass spectrometry (CE MS), the partial filling technique was applied to avoid the introduction of nonvolatile chiral selectors into the CE MS interface. By replacing the nonvolatile electrolytes in the running buffer by volatile ones, the separation conditions employed in CE with the UV detection method could be transferred to CE MS. | TANAKA Yoshihide (Department of Analytical Chemistry, Nippon Boehringer Ingelheim Co. Ltd., 3 10 1, Yato, Kawanishi, Hyogo 666 0193, Japan) | 2002 | 色谱2002，20，4： | 8 |
| 2 | Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies显示文摘Non-alcoholic fatty liver disease(NAFLD)is a major cause of liver disease around the world.It includes a spectrum of conditions from simple steatosis to non-alcoholic steatohepatitis(NASH)and can lead to fibrosis,cirrhosis,liver failure,and/or hepatocellular carcinoma.NAFLD is also associated with other medical conditions such as obesity,diabetes mellitus(DM),metabolic syn-drome,hypertension,insulin resistance,hyperlipidemia,and cardiovascular disease(CVD).In diabetes,chronic hyperglycemia contributes to the development of both macro-and microvascular conditions through a variety of metabolic pathways.Thus,it can cause a variety of metabolic and hemodynamic conditions,including upregulated advanced glycation end-products(AGEs)synthesis.In our previous study,the most abundant type of toxic AGEs(TAGE);i.e.,glyceraldehyde-derived AGEs,were found to make a significant contribution to the pathogenesis of DM-induced angiopathy.Furthermore,accumulating evidence suggests that the binding of TAGE with their receptor(RAGE)induces oxidative damage,promotes inflammation,and causes changes in intracellular signaling and the expression levels of certain genes in various cell populations including hepatocytes and hepatic stellate cells.All of these effects could facilitate the pathogenesis of hypertension,cancer,diabetic vascular complications,CVD,dementia,and NASH.Thus,inhibiting TAGE synthesis,preventing TAGE from binding to RAGE,and downregulating RAGE expression and/or the expression of associated effector molecules all have potential as therapeutic strategies against NASH.Here,we examine the contributions of RAGE and TAGE to various conditions and novel treatments that target them in order to prevent the development and/or progression of NASH. | Masayoshi Takeuchi Jun-ichi Takino Akiko Sakasai-Sakai Takanobu Takata Tadashi Ueda Mikihiro Tsutsumi Hideyuki Hyogo Sho-ichi Yamagishi | 2014 | World Journal of Hepatology2014，6，12： | 5 |
| 3 | Genome-wide scan revealed that polymorphisms in the PNPLA3 , SAMM50 , and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan显示文摘 | Takuya Kitamoto Aya Kitamoto Masato Yoneda Hideyuki Hyogo Hidenori Ochi Takahiro Nakamura Hajime Teranishi Seiho Mizusawa Takato Ueno Kazuaki Chayama Atsushi Nakajima Kazuwa Nakao Akihiro Sekine Kikuko Hotta | 2013 | Human Genetics2013，，7： | 5 |
| 4 | Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH显示文摘 | Yuki Kimura Hideyuki Hyogo Sho-ichi Yamagishi Masayoshi Takeuchi Tomokazu Ishitobi Yoshitaka Nabeshima Koji Arihiro Kazuaki Chayama | 2010 | Journal of Gastroenterology2010，，7： | 3 |
| 5 | Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study显示文摘 | Yuichiro Eguchi Hideyuki Hyogo Masafumi Ono Toshihiko Mizuta Naofumi Ono Kazuma Fujimoto Kazuaki Chayama Toshiji Saibara | 2012 | Journal of Gastroenterology2012，，5： | 3 |
| 6 | Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease显示文摘AIM:To investigate a simple noninvasive scoring system for predicting liver cirrhosis in nonalcoholic fatty liver disease(NAFLD)patients.METHODS:A total of 1048 patients with liver-biopsyconfirmed NAFLD were enrolled from nine hepatology centers in Japan(stage 0,216;stage 1,334;stage 2,270;stage 3,190;stage 4,38).The weight and height of the patients were measured using a calibrated scale after requesting the patients to remove their shoes and any heavy clothing.Venous blood samples were obtained in the morning after the patients had fasted overnight for 12 h.Laboratory evaluation was performed in all patients.Statistical analysis was conducted using SPSS version 12.0.Continuous variables were expressed as mean±SD.RESULTS:The optimal cutoff value of platelet count,serum albumin,and aminotransferase/alanine aminotransferase ratio(AAR)was set at<15.3 104/μL,<4.0g/dL,and>0.9,respectively,by the receiver operating characteristic curve.These three variables were combined in an unweighted sum(platelet count=1 point,serum albumin=1 point,AAR=1 point)to form an easily calculated composite score for predicting cirrhosis in NAFLD patients,called the PLALA(platelet,albumin,AAR)score.The diagnosis of PLALA≥2 had sufficient accuracy for detecting liver cirrhosis in NAFLD patients.CONCLUSION:The PLALA score may be an ideal scoring system for detecting cirrhosis in NAFLD patients with sufficient accuracy and simplicity to be considered for clinical use. | Takaomi Kessoku Yuji Ogawa Masato Yoneda Kento Imajo Yoshio Sumida Yuichiro Eguchi Hideki Fujii Hideyuki Hyogo Masafumi Ono Yasuaki Suzuki Takumi Kawaguchi Kazuaki Chayama Saiyu Tanaka Kazuma Fujimoto Keizo Anzai Toshiji Saibara Michio Sata Yoshito Itoh Atsushi Nakajima Takeshi Okanoue Japan Study Group of NAFLD(JSG-NAFLD) | 2014 | World Journal of Gastroenterology2014，20，29： | 2 |
| 7 | Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia显示文摘 | Hideyuki Hyogo Susumu Tazuma Koji Arihiro Keiko Iwamoto Yoshitaka Nabeshima Motoki Inoue Tomokazu Ishitobi Michihiro Nonaka Kazuaki Chayama | 2008 | Metabolism2008，，12： | 2 |
| 8 | Medium-term prognosis of young Japanese adults having acute myocardial infarction显示文摘 | Kohno Y Yamaguchi S Arihara M Hadase M Hyogo M | 2006 | Circ J2006，70，5： | 1 |
| 9 | Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts显示文摘 | Hyogo H Roy S Paigen B | 2002 | J Biol Chem2002，277，34： | 1 |
| 10 | Phospholipid alterations in hepatocyte membranes and transporter protein changes in cholestatic rat model显示文摘 | Hyogo H Tazuma S Nishioka T | 2001 | Dig Dis Sci2001，46，10： | 1 |
| 11 | IL28B polymorphism is associated with fatty change in the liver of chronic hepatitis C patients显示文摘 | Mayu Ohnishi Masataka Tsuge Tomohiko Kohno Yizhou Zhang Hiromi Abe Hideyuki Hyogo Yuki Kimura Daiki Miki Nobuhiko Hiraga Michio Imamura Shoichi Takahashi Hidenori Ochi C. Hayes Shinji Tanaka Koji Arihiro Kazuaki Chayama | 2012 | Journal of Gastroenterology2012，，7： | 1 |
| 12 | Restoration of gallstone suscepti- bility by leptin in C57BL/6Job/ob mice显示文摘 | Hyogo H Roy S Cohen DE | 2003 | J Lipid Res2003，44，： | 1 |
| 13 | Restoration of gallstone susceptibility by leptin in C57BL/6J ob/ob mice显示文摘 | Hyogo H Roy S Cohen DE | 2003 | J Lipid Res2003，44，6： | 1 |
| 14 | Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study显示文摘 | Yuichiro Eguchi Hideyuki Hyogo Masafumi Ono Toshihiko Mizuta Naofumi Ono Kazuma Fujimoto Kazuaki Chayama Toshiji Saibara | 2012 | Journal of Gastroenterology2012，，5： | 1 |
| 15 | Restoration of gallstone susceptibility by leptin in C57BL/6J ob/ob mice 显示文摘 | HYOGO H ROY S COHEN DE | 2003 | J Lipid Res2003，44，6： | 1 |
| 16 | Pilot study of liraglutide ef- fects in non-alcoholic steatohepatitis and non-alcoholic fatty liver disease with glucose intolerance in Japanese patients (LEAN-J)显示文摘 | Eguehi Y Kitajima Y Hyogo H | 2015 | Hepatol Res2015，45，3： | 1 |
| 17 | Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand 显示文摘 | Nonaka M Tazuma S Hyogo H | 2008 | J Gastroenterol Hepatol2008，23，72： | 1 |
| 18 | Efficacy of radiofrequency ablation for inital recurrent hepatocelluar carcinoma after curative treatment : Comparison with primary cases 显示文摘 | Fukuhara T Aikata H Hyogo lq | 2015 | Eur J Radiol2015，84，8： | 1 |
| 19 | Advanced glycation end products enhance the proliferation and activation of hepatic stellate cells 显示文摘 | Iwamoto K Kanno K Hyogo H | 2008 | J Gastroenterol2008，43，4： | 1 |
| 20 | Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH显示文摘 | Yuki Kimura Hideyuki Hyogo Sho-ichi Yamagishi Masayoshi Takeuchi Tomokazu Ishitobi Yoshitaka Nabeshima Koji Arihiro Kazuaki Chayama | 2010 | Journal of Gastroenterology2010，，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员