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| 1 | Cytotoxic, genotoxic and apoptotic effects of naringenin-oxime relative to naringenin on normal and cancer cell lines显示文摘Objective: To assess and compare the cytotoxic, genotoxic, apoptotic and reactive oxygen species(ROS) generating effects of naringenin(NG) and its new derived compound naringenin-oxime(NG-Ox) on MCF-7, HT-29, PC-12 cancer and L-929 normal cell lines.Methods: The cells were incubated with different doses of NG-Ox and NG(50–1 000 mmol/L) for 24 h. The cell viability was assessed based on ATP cell viability assay.Intracellular accumulation of ROS was determined using the fluorescent probes 2070-dichlorodihydrofluorescin diacetate. Genotoxic effects were evaluated by alkaline single cell gel electrophoresis assay(comet assay) and, the apoptotic effect was evaluated by acridine orange staining at below the IC50 levels.Results: Both NG-Ox and NG exhibited cytotoxic, genotoxic and apoptotic effects and resulted in increased ROS values in a dose-dependent manner. The effects were more pronounced on cancer cell lines. The cytotoxic, genotoxic and apoptotic effects of NG-Ox were higher than that of NG in all cell lines. Significant correlations were observed between cell viability, DNA damage, apoptosis and ROS, in all cell lines exposed to either NG-Ox or NG.Conclusions: This study showed that both NG-Ox and NG possess cytotoxic, genotoxic and apoptotic activities through the production of ROS on cells, NG-Ox being the more effective one. Therefore, derived compound of NG might be used as antiproliferative agents for the treatment of cancer. | Abdurrahim Kocyigit Ismail Koyuncu Murat Dikilitas Fatemeh Bahadori Baki Turkkan | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，10： | 2 |
| 2 | Reactive dye removal in dye/ salt mixtures by nanofiltration membranes containing vinylsulphone dyes effects of feed concentration and cross folw velocity显示文摘 | Ismail Koyuncu | 2002 | Desalination2002，143，3： | 1 |
| 3 | Advaneed physicochemical treatment experiences on young municipal landfill leachates显示文摘 | OZTURK IZZET MAHMUT ALTINBAS ISMAIL KOYUNCU | 2003 | Waste Management2003，，5： | 1 |
| 4 | Reactive dye removal in dye/sah mixtures by nanofihration membranes containing vinylsulphone dyes effects of feed concentration and cross flow velocity显示文摘 | Ismail Koyuncu | 2002 | Desalination2002，143，3： | 1 |
| 5 | Desalination ofproduced water from oil production fields by membrane processes 显示文摘 | Mehmet Cakmakca Necati Kayaalp Ismail Koyuncu | 2008 | Desalination2008，222，： | 1 |
| 6 | Advanced physicochemical treatment experiences on young municipal landfill leachates 显示文摘 | Ozturk Izzet Mahmut Altinbas Ismail Koyuncu | 2003 | Waste Management2003，23，5： | 1 |
| 7 | Reactive dye removal in dye/salt mixtures by nanofiltration membranes containing vinylsulphone dyes effects of feed concentration and cross flow velocity 显示文摘 | Ismail Koyuncu | 2002 | Desalination2002，143，3： | 1 |
| 8 | Removal of trihalomethanes from drinking water by nanofihration membranes显示文摘 | Vedat Uyak Ismail Koyuncu Ibrahim Oktem | 2008 | Hazardous Materials2008，152，2： | 1 |
| 9 | An advanced treatment of high-strength opium alkaloid processing industry wastewaters with membrane technology:pretreatment,fouling and retention characteristics of membranes显示文摘 | Ismail Koyuncu | 2003 | Desalination2003，，155： | 1 |
| 10 | Removal of trihalomethanes from drinking water by nanofiltration membranes显示文摘 | Ismail Koyuncu Ibrahim Oktem | 2007 | Journal of Hazardous Materials2007，082，： | 1 |
| 11 | Desalination of produced water from oil production fields by membrane processes 显示文摘 | Mehmet Cakmakea Necati Kayaalp Ismail Koyuncu | 2008 | Desalination2008，222，： | 1 |
| 12 | Reuse of reactive dyehouse wastewater by nanofiltration: process water quality and economical implications 显示文摘 | Ismail Koyuncu Dincer Topacik Ebubekir Yuksel | 2004 | Separation and Purification Technology2004，36，： | 1 |
| 13 | Influence of dyes, salts and auxiliary chemicals on the nanofiltration of reactive dye baths: experimental observations and model verification显示文摘 | Ismail Koyuncu | 2003 | Desalination2003，154，： | 1 |
| 14 | Advanced physico-chemical treatment experiences on young municipal landfill leachates 显示文摘 | LZZET OZTURK MAHMUT ALTINBAS ISMAIL KOYUNCU | 2003 | Waste Management2003，23，： | 1 |
| 15 | Desalination of produced water from oil production fields by membrane processes显示文摘 | Mehmet Cakmakca Necati Kayaalp Ismail Koyuncu | 2008 | Desalination2008，22，2： | 1 |
| 16 | The production of polysulfone (PS) membrane with silver nanoparticles (AgNP): Physical properties, filtration performances, and biofouling resistances of membranes显示文摘 | Derya Y. Koseoglu-Imer Borte Kose Mahmut Altinbas Ismail Koyuncu | 2013 | Journal of Membrane Science2013，，： | 1 |
| 17 | Removal of tri- halomethanes from drinking water by nanofiltration membranes 显示文摘 | Vedat Uyak Ismail Koyuncu Ibrahim Oktem | 2008 | Hazardous Materials2008，152，2： | 1 |
| 18 | Re- moval of trihalomethanes from drinking water by nanofil- tration membranes显示文摘 | Vedat Uyak Ismail Koyuncu lbrahim Oktem | 2008 | Journal of Hazardous Materials2008，152，2： | 1 |
| 19 | Desalination of produced water from oil production fields by membrane processes 显示文摘 | Mehmet-akmakca Neeati Kayaatp Ismail Koyuncu | 2008 | Desalination2008，222，： | 1 |
| 20 | Reactive dye removal in dye/salt mixtures by nanofiltration membranes containing vinylsulpone dyes Effects of feed concentration and cross flow velocity显示文摘 | Ismail Koyuncu | 2002 | Desalinaition2002，，143： | 1 |
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