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| 1 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Natural killer T cells and non-alcoholic fatty liver disease:Fat chews on the immune system显示文摘Natural killer T cells (NKT) are an important subset of T lymphocytes. They are unique in their ability to produce both T helper 1 and T helper 2 associated cytokines, thus being capable of steering the immune system into either inflammation or tolerance. Disruption of NKT cell numbers or function results in severe deficits in immune surveillance against pathogens and tumor cells. Growing experimental evidence suggests that hepatosteatosis may reduce resident hepatic as well as peripheral NKT cells. Those models of hepatosteatosis and the change in NKT cell numbers are associated with a disruption of cytokine homeostasis, resulting in a more pronounced release of proinflammatory cytokines which renders the steatotic liver highly susceptible to secondary insults. In this letter to the editor, we focus on recently published data in the World Journal of Gastroenterology by Xu and colleagues demonstrating reduced peripheral NKT cells in patients with non-alcoholic fatty liver disease, compare those findings with ours and others in different animal models of hepatosteatosis, and hypothesize about the potential underlying mechanism. | Michael Kremer Ian N Hines | 2008 | World Journal of Gastroenterology2008，14，3： | 3 |
| 4 | Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort显示文摘 | Ian Jacobs Aleksandra Gentry-Maharaj Matthew Burnell Ranjit Manchanda Naveena Singh Aarti Sharma Andy Ryan Mourad W Seif Nazar N Amso Gillian Turner Carol Brunell Gwendolen Fletcher Rani Rangar Kathy Ford Keith Godfrey Alberto Lopes David Oram Jonathan He | 2011 | Lancet Oncology2011，，1： | 2 |
| 5 | A novel medium throughput quantitative competitive PCR technology to simultaneously measure mRNA levels from multiple genes显示文摘 | Junlong Z Ian N M Day and Christopher D B | 2002 | Nucleic Acids Research2002，30，5： | 1 |
| 6 | Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease 显示文摘 | SANTIAGO R TOM R G IAN N M D | 2007 | Hum Genet2007，122，： | 1 |
| 7 | A qualita- tive systematic review of head-to-head randomized con- trolled trials of oral analgesics in neuropathic pain显示文摘 | C Peter N Watson Ian Gilron Jana Sawynok | 2010 | Pain Res Manag2010，15，3： | 1 |
| 8 | A two-dimensional spectrum for bistatic SAR processing using series reversion显示文摘 | Yew L N Frank Wong Ian G Cumming | 2007 | IEEE Geoscience Remote Sensing Letters2007，4，1： | 1 |
| 9 | Arithmetic coding for data compression显示文摘 | Ian H W Radford N W JohnCG | 1987 | Communication of the ACM1987，30，6： | 1 |
| 10 | Criteria used by venture capitalists to evaluate new proposals显示文摘 | IAN C MACMILLAN ROBIN SIEGEL SUBBA NARASIMHA P N | 1985 | Journal of Business Venturing 11985，，： | 1 |
| 11 | Activation of transforming growth f actor-β1 and early atherosclerosis in systemic lupus erythematosus显示文摘 | Michelle Jackson Yasmeen Ahmad Ian N Bruce | 2006 | Arthritis Research & Therapy2006，8，3： | 1 |
| 12 | Distribution and abundance of Antarctic krill (Euphausia superba) off East Antarctica (80-150E) during the Austral summer of 1995/1996显示文摘 | Tim P Stephen N Ian H | 2000 | Deep-Sea Res I/2000，47，： | 1 |
| 13 | Black carbon-inclusive modeling approaches for estimating lhe aquatic fate of dibenzop-dioxins and dibenzofurans显示文摘 | Armitage J M Cousins Ian T Persson N Johan | 2008 | Environmental Science & Technology2008，42，10： | 1 |
| 14 | Real -time PCR in virology显示文摘 | Ian MM Katherine EA Andreas N | 2002 | Nucleic Acids Res2002，30，6： | 1 |
| 15 | Grid services for distributed system integration显示文摘 | Ian F Carl K Jeffery N | 2002 | IEEE Computer2002，35，6： | 1 |
| 16 | Using expected values to simplify decision making under uncertainty显示文摘 | Ian Durbach N Theodor Stewart J | | 0，，： | 1 |
| 17 | Real-time PCR in virology显示文摘 | Ian MM Katherine EA Andreas N | 2002 | Nucleic Acids Res2002，30，6： | 1 |
| 18 | Aqueous and enzymatic p processes for edible oil extraction: a review 显示文摘 | ROSENTHAL A PYLE D L N IRANJ IAN K | 1996 | Enzyme and Microbial Technology1996，9，： | 1 |
| 19 | Percutaneous biliary metal wall stenting in malignant obstructive jaundice显示文摘 | Adrian A Indar Dileep N Lobo Andrew D Gilliam Roger Gregson Ian Davidson Simon Whittaker John Doran Brian J Rowlands Ian J Beckingham | 2003 | European Journal of Gastroenterology & Hepatology2003，，： | 1 |
| 20 | Recent technological developments in cyanate ester resins显示文摘 | Ian Hamerton John N Hay | 1998 | High Perform Polym1998，10，2： | 1 |
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