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| 1 | Bone Morphogenetic Protein (BMP) signaling in development and human diseases显示文摘Bone Morphogenetic Proteins(BMPs)are a group of signaling molecules that belongs to the Transforming Growth Factor-b(TGF-b)superfamily of proteins.Initially discovered for their ability to induce bone formation,BMPs are now known to play crucial roles in all organ systems.BMPs are important in embryogenesis and development,and also in maintenance of adult tissue homeostasis.Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects,highlighting the essential functions of BMPs.In this review,we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in development.A significant portion of this review is devoted to the prominent human pathologies associated with dysregulated BMP signaling. | Richard N.Wang Jordan Green Zhongliang Wang Youlin Deng Min Qiao Michael Peabody Qian Zhang Jixing Ye Zhengjian Yan Sahitya Denduluri Olumuyiwa Idowu Melissa Li Christine Shen Alan Hu Rex C.Haydon Richard Kang James Mok Michael J.Lee Hue L.Luu Lewis L.Shi | 2014 | Genes & Diseases2014，1，1： | 47 |
| 2 | Insulin-like growth factor(IGF)signaling in tumorigenesis and the development of cancer drug resistance显示文摘One of the greatest obstacles to current cancer treatment efforts is the development of drug resistance by tumors.Despite recent advances in diagnostic practices and surgical interventions,many neoplasms demonstrate poor response to adjuvant or neoadjuvant radiation and chemotherapy.As a result,the prognosis for many patients afflicted with these aggressive cancers remains bleak.The insulin-like growth factor(IGF)signaling axis has been shown to play critical role in the development and progression of various tumors.Many basic science and translational studies have shown that IGF pathway modulators can have promising effects when used to treat various malignancies.There also exists a substantial body of recent evidence implicating IGF signaling dysregulation in the dwindling response of tumors to current standard-of-care therapy.By better understanding both the IGF-dependent and-independent mechanisms by which pathway members can influence drug sensitivity,we can eventually aim to use modulators of IGF signaling to augment the effects of current therapy.This review summarizes and synthesizes numerous recent investigations looking at the role of the IGF pathway in drug resistance.We offer a brief overview of IGF signaling and its general role in neoplasia,and then delve into detail about the many types of human cancer that have been shown to have IGF pathway involvement in resistance and/or sensitization to therapy.Ultimately,our hope is that such a compilation of evidence will compel investigators to carry out much needed studies looking at combination treatment with IGF signaling modulators to overcome current therapy resistance. | Sahitya K.Denduluri Olumuyiwa Idowu Zhongliang Wang Zhan Liao Zhengjian Yan Maryam K.Mohammed Jixing Ye Qiang Wei Jing Wang Lianggong Zhao Hue H.Luu | 2015 | Genes & Diseases2015，2，1： | 21 |
| 3 | A signature of immune function genes associated with recurrence-free survival in breast cancer patients显示文摘 | Maria Libera Ascierto Maciej Kmieciak Michael O. Idowu Rose Manjili Yingdong Zhao Margaret Grimes Catherine Dumur Ena Wang Viswanathan Ramakrishnan Xiang-Yang Wang Harry D. Bear Francesco M. Marincola Masoud H. Manjili | 2012 | Breast Cancer Research and Treatment2012，，3： | 2 |
| 4 | Simple, rapid determination of enrofloxacin and ciprofloxacin in bovine milk and plasma by high- performance liquid chromatography with fluorescence detection 显示文摘 | Olutosin R Idowu James O Peggins | 2004 | Journal of Pharmaceutical and Biomedical Analysis2004，35，1： | 1 |
| 5 | Laryngeal abductor muscle reinnervation in a pig model显示文摘 | BIRCHALL M IDOWU B MURISON P | 2004 | Acta Otolaryngol2004，124，： | 1 |
| 6 | Molecular signatures most- ly associated with NK cells are predictive of relapse free survival in breast cancer patients 显示文摘 | Ascierto ML Idowu MO Zhao Y | 2013 | J Transl Med2013，11，1： | 1 |
| 7 | Problem-based learning case writing by students based on early years clinical attach- ments ;a focus group evaluation显示文摘 | Idowu Y Muir E Easton G | 2016 | JRSM Open2016，7，20： | 1 |
| 8 | Effect of germination and degree of grind (coarse/fine) on the extract and sugar contents of sorghum malts显示文摘 | Lasekan OO Idowu MA Lasekan W | 1995 | Food chem1995，53，： | 1 |
| 9 | CD44( + )/CD24(-/low) cancer stem/progenitor cells are more abundant in triple - negative invasive breast carcinoma phenotype and are associated with poor outcome 显示文摘 | Idowu MO Kmieciak M Manjili MH | 2012 | Hum Pathol2012，43，3： | 1 |
| 10 | 加纳阿善堤地区农户参与稻田项目的决定因素研究显示文摘本文对加纳阿哈福阿诺南区(Ahafo Ano Southdistrict)农户参与稻田项目的决定因素进行研究。稻田项目的实施,主要基于加纳稻米消费的扩张,导致了对生产自给的需求。为此,日本的一些机构在加纳的较低洼地区引入了稻米的生产。当然,在参与稻田项目的全部三阶段(1997—2001,2002—2004和2004—2009)的农户中,也存在着不同的问题。因此,在前两个阶段结束和第三个阶段接近完成的情况下,研究农户参与稻田项目的决定因素,从而促进项目逐步完善就显得尤为重要。由于稻田开发项目主要集中在阿哈福阿诺南区,这一地区分布有主要的流域,因此,本研究也主要在此地区进行。受访者主要从5个村庄中随机抽取,这5个村庄涵盖了项目的所有3个阶段,共选取了225名农民,通过结构式问卷调查方式搜集了相关资料。论文运用描述性统计方法分析了样本农民的社会经济特点,同时运用Probit模型对影响农户参与稻田项目的决定因素进行了研究。结果表明,样本中多数农民为50岁以下男性,他们具有较高的教育水平,同时信奉基督教,但他们在低地种植水稻的经验不到5年,水稻种植面积不到5英亩,约有61%的接受访问者每户有5至10人,样本中参与项目的人数少于没有参加项目的人数。从Probit模型的结果来看,确定模型拟合度的卡方值在1%的统计水平上显著,“参与稻田项目的持续性”(t=5.02)和“村庄稻田项目的起始时间”(t=-1.53)两变量分别在5%和10%的统计水平上显著。从文中也可以看出,在引进稻田项目的同时,也引进了适当的田间管理和水资源管理。为了确保农民参与稻田项目的可持续发展,也有必要对论文中基于项目3阶段分析所揭示的重要的社会变量给予政策上的重视。 | 中岛邦公(Kunitada Nakashima) 艾杜瓦·奥拉德利(Oladele, O. Idowu) 布里·莫罗(Moro M. Buri) 若月利之(Toshiyuki Wakatsuki) | 2007 | 中国农业经济评论2007，5，4： | 1 |
| 11 | H2 S incorporation in coal precursors : origins of organic sulphur in coal 显示文摘 | Casagrande D J Idowu G Friedman A | 1979 | Nature1979，282，： | 1 |
| 12 | Rat model of food-induced non-obese-type 2 diabetes mellitus: comparative pathophysiology and histopathology 显示文摘 | Akindele O Adcyi Babatunde A Idowu Chiedu F Mafiana | 2012 | lnt J Physiol Pathophysiol Pharmacol2012，4，1： | 1 |
| 13 | Simple, rapid determination of enrofloxacin and ciprofloxacin in bovine milk and plasma by high -performance liquid chromatography with fluorescence detection 显示文摘 | Idowu OR Peggins JO | 2004 | Journal of Pharmaceutical and Biomedical Analysis2004，35，1： | 1 |
| 14 | Stabilization of fibronectin mats with micromolar concentration of copper显示文摘 | Ahmed Z Idowu BD Brown RA | | 0，，： | 1 |
| 15 | Potential therapeutic tar- gets for ehordoma : P13 K/AKT/TSCI/TSC2/mTOR pathway 显示文摘 | Presneau N Shalaby A Idowu B | 2009 | Br J Cancer2009，100，9： | 1 |
| 16 | Analysis of surface roughness in relation to soil loss and runoff at high rainfall intensities显示文摘 | Idowu O J Rickson R J Godwin R J | 2002 | Hydrological Processes2002，16，12： | 1 |
| 17 | Prevalence of venous thromboembolism at post-mortem in an African population: a cause for concern显示文摘 | Sotunmbi PT Idowu AT Akang EE | 2006 | Afr J Med Med Sci2006，35，3： | 1 |
| 18 | Biological therapy in cancer显示文摘 | Idowu O E | 2001 | Niger J Med2001，10，2： | 1 |
| 19 | Pore-scale modelling of CO2-brine flow properties at In Salah,Algeria显示文摘 | LOPEZ O IDOWU N MOCK A | 2011 | Energy Procedia2011，4，1： | 1 |
| 20 | 胚后发育期臭腹腺蝗中的血细胞种类(英文)显示文摘应用血球计数器统计了胚后发育期臭腹腺蝗Zonocerus variegatus中存在的血细胞类型和数目。从1龄幼虫至成虫的发育阶段中共观察到6种血细胞类型,即原血细胞(PRS)、浆血细胞(PLS)、粒细胞(GRS)、珠血细胞(SPS)、绛色细胞(OES)和adipohaemocytes(ADS)。不过,在1龄幼虫期未发现OES。在这6种血细胞中,PLS的总平均数最高,OES的总平均数最低。成虫期的血细胞数目显著高于其他发育阶段(P<0.05),而1龄幼虫和2龄幼虫期的血细胞数目不存在显著差异(P>0.05)。 | ADEMOLU Kehinde Olutoyin IDOWU Adewunmi Babatunde OLATUNDE Ganiu | 2010 | 昆虫学报2010，53，4： | 1 |
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