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| 1 | Endoscopic appearance of AIDS-related gastrointestinal lymphoma with c-MYC rearrangements: Case report and literature review显示文摘Acquired immune deficiency syndrome (AIDS)-related lymphoma (ARL) remains the main cause of AIDS-related deaths in the highly active anti-retroviral therapy (HAART) era. Recently, rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma. Here, we report a rare case of gastrointestinal (GI)-ARL with MYC rearrangements and coinfected with Epstein-Barr virus (EBV) infection presenting with various endoscopic findings. A 38-yearold homosexual man who presented with anemia and was diagnosed with an human immunodeficiency virus infection for the first time. GI endoscopy revealed multiple dish-like lesions, ulcerations, bloody spots, nodular masses with active bleeding in the stomach, erythematous flat lesions in the duodenum, and multiple nodular masses in the colon and rectum. Magnified endoscopy with narrow band imaging showed a honeycomb-like pattern without irregular microvessels in the dish-like lesions of the stomach. Biopsy specimens from the stomach, duodenum, colon, and rectum revealed diffuse large B-cell lymphoma concomitant with EBV infection that was detected by high tissue EBV-polymerase chain reaction levels and Epstein-Barr virus small RNAs in situ hybridization. Fluorescence in situ hybridization analysis revealed a fusion between the immunoglobulin heavy chain (IgH) and c-MYC genes, but not between the IgH and BCL2 loci. After 1-mo of treatment with HAART and R-CHOP, endoscopic appearance improved remarkably, and the histological features of the biopsy specimens revealed no evidence of lymphoma. However, he died from multiple organ failure on the 139 th day after diagnosis. The cause of his poor outcome may be related to MYC rearrangement. The GI tract involvement in ARL is rarely reported, and its endoscopic findings are various and may be different from those in non-AIDS GI lymphoma; thus, we also conducted a literature review of GI-ARL cases. | Shohei Tanaka Naoyoshi Nagata Sohtaro Mine Toru Igari Taiichiro Kobayashi Jun Sugihara Haruhito Honda Katsuji Teruya Yoshimi Kikuchi Shinichi Oka Naomi Uemura | 2013 | World Journal of Gastroenterology2013，19，29： | 3 |
| 2 | Clinical presentation of obturator hernia and review of the literature显示文摘 | Igari K Ochiai T Aihara A | 2010 | Hernia2010，14，4： | 1 |
| 3 | Comparison of specificities between two interferon-gamma release assays in Japan显示文摘 | Higuchi K Sekiya Y Igari H | 2012 | Int J Tuberc Lung Dis2012，16，9： | 1 |
| 4 | Constitutive activa- tion of a CC-NB-LRR protein alters morphogenesis through the cytokinin pathway in Arabidopsis 显示文摘 | Igari K Endo S Hibara K | 2008 | The Plant Journal2008，55，1： | 1 |
| 5 | Association of tumor necrosis factor-α gene promoter polymorphism with the presence of chronic obstructive pulmonary disease 显示文摘 | Sakao S Tatsumi K Igari H | 2001 | Am J Respir Crit Care Med2001，163，2： | 1 |
| 6 | Expression of homeodomain protein CDX2 in gallbladder carcinomas显示文摘 | Xiang-Song Wu Yoshimitsu Akiyama Toru Igari Tohru Kawamura Susumu Hiranuma Toshikatsu Shibata Kouji Tsuruta Morio Koike Shigeki Arii Yasuhito Yuasa | 2005 | Journal of Cancer Research and Clinical Oncology2005，，5： | 1 |
| 7 | Immunogenicity of whole parasite vaccines against plasmodium falciparum involves malarial hemozoin and host TLR9显示文摘 | Coban C Igari Y Yagi M | 2010 | Cell Host Microbe2010，7，1： | 1 |
| 8 | Association of tumor necrosis factoragene promoter polymorphism with the presence of COPD显示文摘 | Sakao S Tatumi K Igari H | 2001 | Am J Respit Crit Cam Med2001，163，2： | 1 |
| 9 | Koch ' s phenomenon after BCG vaccination and the two-step tuberculin test in elementary school children显示文摘 | Igari H Onozaki I Sunami Y | 1998 | Kekkaku1998，73，6： | 1 |
| 10 | Enzymatically activated microencapsuled liposome can provide pulsatile drug release 显示文摘 | Kibat PG Igari Y Wheatley MA | 1990 | FASEB J1990，4，8： | 1 |
| 11 | In vitro antimicrobial activity of carbapenem antibiotics against Pseudomonas aeruginosa, measured using a low- concentration Mueller-Hinton agar culture medium显示文摘 | Igari J | 1999 | Jpn J Antibiot1999，52，6： | 1 |
| 12 | Dianosis of nutcracker syndrome of the left renal vein:value of the corticomedullary phase of helical CT显示文摘 | Igari H | 2001 | Nippon Hinyokika Gakkai Zasshi(Japan)2001，61，： | 1 |
| 13 | Inelas-tic Analysis of New Thermal Ratchetting Due to aMoving Temperature Front 显示文摘 | IGARI T KOBAYASHI M YOSHIDA F | 2002 | International Journalof Plasticity2002，18，： | 1 |
| 14 | Clinical presentation of obturator hernia and review of the literature显示文摘 | Igari K Ochiai T Aihara A | 2010 | Hernia2010，14，4： | 1 |
| 15 | Mechanism - based E-valuation of Thermal Ratcheting Due to TravelingTemperature Distribution 显示文摘 | IGARI T WADA H UETA M | 2000 | Journal of PressureVessel Technology - Transactions of the ASME2000，122，： | 1 |
| 16 | High temperature strength and inelastic behavior of plate-fin structures for HTGR 显示文摘 | Kawashima F Igari T Miyoshi Y | 2007 | Nuclear Engineering and Design2007，237，6： | 1 |
| 17 | Clinical presentation of obturator hernia and review of the literature 显示文摘 | Igari K Ochiai T Aihara A | 2010 | Hernia2010，14，4： | 1 |
| 18 | Association of tumor necrosis factor a gene promoter polymorphism with the presence of chronic obstructive pulmonary disease显示文摘 | Sakao S Tatsumi K Igari H et el | 2001 | Am J Respir Crit Care Med2001，163，： | 1 |
| 19 | , How to successfully promote ICT usage: A comparative analysis of Denmark and Japan显示文摘 | Igari N | 2014 | Telematics and Informatics2014，31，1： | 1 |
| 20 | Enzymatically activated microeneapulated liposomes can provide pulsatile drug release显示文摘 | Kibat P G Igari Y Wheatley M A Eisen H N Langer R | 1990 | FASEB J1990，4，： | 1 |
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