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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression显示文摘 | María J. Bueno Ignacio Pérez de Castro Marta Gómez de Cedrón Javier Santos George A. Calin Juan C. Cigudosa Carlo M. Croce José Fernández-Piqueras Marcos Malumbres | 2008 | Cancer Cell2008，，： | 2 |
| 3 | Variants at the promoter of the interleukin-6gene are associated with severity and outcome of pneumococcal community-acquired pneumonia显示文摘 | Ignacio Marítn-Loeches Jordi Solé-Violán Felipe Rodríguez de Castro | 2012 | Intensive Care Medicine2012，38，2： | 1 |
| 4 | Histamine, polyamines, and cancer显示文摘 | Miguel ángel Medina Ana Rodr??guez Quesada Ignacio Nú?ez de Castro Francisca Sánchez-Jiménez | 1999 | Biochemical Pharmacology1999，，12： | 1 |
| 5 | Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression显示文摘 | Mara J Bueno Ignacio Pérez de Castro Marta G ómez de Cedrón | 2008 | Cancer Ce112008，13，6： | 1 |
| 6 | Intraoperative ERCP for the Management of Choledocholithiasis: A Comparative Study显示文摘 | Luis R. Rabago Maria Delgado Cristina de Vicente Ignacio Moral Nuria Ventosa Jose Luis Castro Jaime Vazquez Echarri Rosa Llorente Jose Romeo Francisco Gea Jose Luis Martinez Veiga | 2004 | Gastrointestinal Endoscopy2004，，5： | 1 |
| 7 | Variants at the promoter of the 'intcrleukin -6 gene are associated with severity and outcome of pneumococcal community- acquired pneumonia 显示文摘 | Ignacio Martin - Loeches Jordi So16 - Viol6n Felipe Rodflguez de Castro | 2012 | Intensive Care Medicine2012，38，2： | 1 |
| 8 | Antioxidant enzymes and human diseases显示文摘 | José M. Matés Cristina Pérez-Gómez Ignacio Nú?ez De Castro | 1999 | Clinical Biochemistry1999，，8： | 1 |
| 9 | WIPO Arbitration and Mediation Center: New 2014 WIPO Rules, WIPO FRAND Arbitration 显示文摘 | Heike Wollgast Ignacio de Castro | 2014 | ASA BULLETIN2014，，2： | 1 |
| 10 | Persistent sepsis-induced hypotension without hyperlactatemia: Is it really septic shock?显示文摘 | Glenn Hernandez Ricardo Castro Carlos Romero Claudio de la Hoz Daniela Angulo Ignacio Aranguiz Jorge Larrondo Andres Bujes Alejandro Bruhn | 2011 | Journal of Critical Care2011，，4： | 1 |
| 11 | Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR-ABL1 Oncogene Expression显示文摘 | María J. Bueno Ignacio Pérez de Castro Marta Gómez de Cedrón Javier Santos George A. Calin Juan C. Cigudosa Carlo M. Croce José Fernández-Piqueras Marcos Malumbres | 2008 | Cancer Cell2008，，6： | 1 |
| 12 | 嵌入式数字课桌进入校园显示文摘在巴西,嵌入式数字课桌以其动态的交互式界面和海量信息传载,已经取代传统课桌遍布校园,并得到了广泛应用。 | Victor Pellegrini Mammana Cynthia Yukiko Hiraga Ana Maria Pellegrini Daniel den Engelsen LuizAlberto Castro de Almeida Alexandre Cndido de Paulo Gustavo Junior Alves Miguel Joao Neto Carlos Ignacio Zamitti Mammana Antonio Carlos Camargo do Amaral 王鹏 | 2010 | 现代显示2010，，9： | 0 |
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