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| 1 | Crosstalk between angiogenesis, cytokeratin-18, and insulin resistance in the progression of non-alcoholic steatohepatitis显示文摘AIM: To elucidate the possible crosstalk between angiogenesis, cytokeratin-18 (CK-18), and insulin resistance (IR) especially in patients with non-alcoholic steatohepatitis (NASH).METHODS: Twenty-eight patients with NASH and 11 with simple fatty liver disease (FL) were enrolled in this study and underwent clinicopathological examination. The measures of angiogenesis, CK-18, and IR employed were CD34-immunopositive vessels, CK-18immunopositive cells, and homeostasis model assessment of IR (HOMA-IR), respectively. The correlations of these factors with NASH were elucidated.RESULTS: Significant development of hepatic neovascularization was observed only in NASH, whereas almost no neovascularization could be observed in FL and healthy liver. The degree of angiogenesis was almost parallel to liver fibrosis development, and both parameters were positively correlated. Similarly, CK-18expression and HOMA-R were signifi cantly increased in NASH as compared with FL and healthy liver. Furthermore, CK-18 and HOMA-IR were also positively correlated with the degree of neovascularization. CONCLUSION: These results indicate that the crosstalk between angiogenesis, CK-18, and IR may play an important role in the onset and progression of NASH. | Mitsuteru Kitade Hitoshi Yoshiji Ryuichi Noguchi Yasuhide Ikenaka Kosuke Kaji Yusaku Shirai Masaharu Yamazaki Masahito Uemura Junichi Yamao Masao Fujimoto Akira Mitoro Masahisa Toyohara Masayoshi Sawai Motoyuki Yoshida Chie Morioka Tatsuhiro Tsujimoto Hideto Kawaratani Hiroshi Fukui | 2009 | World Journal of Gastroenterology2009，15，41： | 9 |
| 2 | Combined treatment of vitamin K_2 and angiotensin-converting enzyme inhibitor ameliorates hepatic dysplastic nodule in a patient with liver cirrhosis显示文摘Although it is well known that the hepatocellular carcinoma (HCC) is an ominous complication in patients with liver cirrhosis, there has been no approved drug to prevent the development of HCC to date. We previously reported that the combined treatment of vitamin K2 (VK) and angiotensin-converting enzyme inhibitor (ACE-I) significantly suppressed the experimental hepatocarcinogenesis. A 66-year-old Japanese woman with hepatitis C virus (HCV)-related liver cirrhosis developed a dysplastic nodule in the liver detected by enhanced computed tomography along with elevation of the tumor markers, namely, alpha-fetoprotein (AFP) and lectin-reactive demarcation (AFP-L3), suggesting the presence of latent HCC. After oral administration of VK and ACE-I, the serum levels of both AFP and AFP-L3 gradually decreased without any marked alteration of the serum aminotransferase activity. After one-year treatment, not only the serum levels of AFP and AFP-L3 returned to the normal ranges, but also the dysplastic nodule disappeared. Since both VK and ACE-I are widely used without serious side effects, this combined regimen may become a new strategy for chemoprevention against HCC. | Hitoshi Yoshiji Ryuichi Noguchi Masaharu Yamazaki Yasuhide Ikenaka Masayoshi Sawai Masatoshi Ishikawa Hideto Kawaratani Tsuyoshi Mashitani Mitsuteru Kitade Kosuke Kaji Masahito Uemura Junichi Yamao Masao Fujimoto Akira Mitoro Masahisa Toyohara Motoyuki Yoshida Hiroshi Fukui | 2007 | World Journal of Gastroenterology2007，13，23： | 5 |
| 3 | Eosinophilic cholecystitis along with pericarditis caused by Ascaris lumbricoides: A case report显示文摘Although the etiology of eosinophilic cholecystitis is still obscure, the postulated causes include allergies, parasites, hypereosinophilic syndrome, and eosinophilic gastroenteritis. It is sometimes accompanied by several complications, but a simultaneous onset with pericarditis is very rares. A 28-year-old woman complained of acute right hypocondrial pain and dyspnea associated with systemic eruption. Several imaging modalities revealed acute cholecystitis and pericarditis with massive pericardial effusion. A marked peripheral blood eosinophilia was observed, and the eruption was diagnosed as urticaria. Her serum had a high titer of antibody against Ascaris lumbricoides . Treatment with albendazole drastically improved all clinical manifestations along with normalization of the imaging features and eosinophilia. We report herein a rare case of simultaneous onset of acute cholecystitis and pericarditis associated with a marked eosinophilia caused by parasitic infection. | Kosuke Kaji Hitoshi Yoshiji Masahide Yoshikawa Masaharu Yamazaki Yasuhide Ikenaka Ryuichi Noguchi Masayoshi Sawai Masatoshi Ishikawa Tsuyoshi Mashitani Mitsuteru Kitade Hideto Kawaratani Masahito Uemura Junichi Yamao Masao Fujimoto Akira Mitoro Masahisa Toyohara Motoyuki Yoshida Hiroshi Fukui | 2007 | World Journal of Gastroenterology2007，13，27： | 3 |
| 4 | Combination of vitamin K 2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma显示文摘 | Hitoshi Yoshiji Ryuichi Noguchi Masahisa Toyohara Yasuhide Ikenaka Mitsuteru Kitade Kosuke Kaji Masaharu Yamazaki Junichi Yamao Akira Mitoro Masayoshi Sawai Motoyuki Yoshida Masao Fujimoto Tatsuhiro Tsujimoto Hideto Kawaratani Masahito Uemura Hiroshi Fuku | 2009 | Journal of Hepatology2009，，2： | 2 |
| 5 | Interferon augments the anti-fibrotic activity of an angiotensin-converting enzyme inhibitor in patients with refractory chronic hepatitis C显示文摘AIM: To evaluate the effect of combination treatment with the interferon (IFN) and angiotensin-converting enzyme inhibitor (ACE-Ⅰ) on several fibrotic indices in patients with refractory chronic hepatitis C (CHC). METHODS: Perindopril (an ACE-Ⅰ; 4 mg/d) and/or natural IFN (3 MU/L; 3 times a week) were administered for 12 mo to refractory CHC patients, and several indices of serum fibrosis markers were analyzed. RESULTS: ACE-Ⅰdecreased the serum fibrosis markers, whereas single treatment with IFN did not exert these inhibitory effects. However, IFN significantly augmented the effects of ACE-Ⅰ, and the combination treatment exerted the most potent inhibitory effects. The serum levels of alanine transaminase and HCV-RNA were not significantly different between the groups, whereas the plasma level of transforming growth factor-b was significantly attenuated almost in parallel with suppression of the serum fibrosis markers. CONCLUSION: The combination therapy of an ACE- Ⅰand IFN may have a diverse effect on disease progression in patients with CHC refractory to IFN therapy through its anti-fibrotic effect. | Hitoshi Yoshiji Ryuichi Noguchi Hideyuki Kojima Yasuhide Ikenaka Mitsuteru Kitade Kosuke Kaji Masahito Uemura Junichi Yamao Masao Fujimoto Masaharu Yamazaki Masahisa Toyohara Akira Mitoro Hiroshi Fukui | 2006 | World Journal of Gastroenterology2006，12，42： | 2 |
| 6 | Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats显示文摘 | Hitoshi Yoshiji Shigeki Kuriyama Junichi Yoshii Yasuhide Ikenaka Ryuichi Noguchi Toshiya Nakatani Hirohisa Tsujinoue Hiroshi Fukui | 2001 | Hepatology2001，，4： | 2 |
| 7 | Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse显示文摘 | Hitoshi Yoshiji Shigeki Kuriyama Junichi Yoshii Yasuhide Ikenaka Ryuichi Noguchi Toshiya Nakatani Hirohisa Tsujinoue Koji Yanase Tadashi Namisaki Hiroo Imazu Hiroshi Fukui | 2002 | Hepatology2002，，4： | 1 |
| 8 | Astaxanthin rich crude extract of Haematoeoccus pluvialis induces cytochrome P450 1A1 mRNA by activating aryl hydrocarbon receptor in rat hepatoma H4IIE cells显示文摘 | Ohno M Darwish W S Ikenaka Y | 2012 | Food Chemistry2012，130，2： | 1 |
| 9 | Purification and characterization of proteinase inhibitors from winged bean (Psophocarpus tetragonolobus L D C) seeds显示文摘 | Shibata H Hara S Ikenaka T | 1986 | J Biochem (Tokyo)1986，99，： | 1 |
| 10 | Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastie lesions and fibrosis development in rats显示文摘 | Yoshiji H Yoshii J Ikenaka Y | 2002 | J Hepatol2002，37，1： | 1 |
| 11 | Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens显示文摘 | SASAKI N MATSUMOTO T IKENAKA Y | 2011 | Pesticide Biochemistry and Physiology2011，100，： | 1 |
| 12 | Disruption of axonal transport in motor neuron diseases 显示文摘 | Ikenaka K Katsuno M Kawai K | 2012 | Int J Mol Sci2012，13，： | 1 |
| 13 | Olig2 transcription factor in the developing and injured forebrain; cell lineage and glial development 显示文摘 | Ono K Takebayashi H Ikenaka K | 2009 | Mol Cells2009，27，4： | 1 |
| 14 | Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats显示文摘 | Yoshiji H Yoshii J Ikenaka Y | 2002 | J Hepatol2002，37，1： | 1 |
| 15 | Attenuation of insulin-resistance-based hepatocarcinogenesis and angiogenesis by combined treatment with branched-chain amino acids and angiotensin-converting enzyme inhibitor in obese diabetic rats显示文摘 | Hitoshi Yoshiji Ryuichi Noguchi Kosuke Kaji Yasuhide Ikenaka Yusaku Shirai Tadashi Namisaki Mitsuteru Kitade Tatsuhiro Tsujimoto Hideto Kawaratani Hiroshi Fukui | 2010 | Journal of Gastroenterology2010，，4： | 1 |
| 16 | Amino acid sequence of protein a-amylase inhibitor from Streptomyces griseo sporeus YM-25 显示文摘 | Murai H Hara H Ikenaka T | 1984 | J Biochem1984，，： | 1 |
| 17 | Vascular en- dothelial growth factor and receptor interaction is a prereq-uisite for murine hepatic fibrogenesis 显示文摘 | Yoshiji H Kuriyama S Yoshii J Ikenaka Y Noguchi R Hicklin D J Wu Y Yanase K Namisaki T Yamazaki M Tsujinoue H Imazu H Masaki T Fukui H | 2003 | Gut2003，52，： | 1 |
| 18 | Micrpquantitative analysis of neutral and amino sugars as fluorescent pyridylamino derivatives by high-performance liquid chromatography 显示文摘 | Takemoto H Hase S Ikenaka T | 1985 | Anal Biochem1985，145，2： | 1 |
| 19 | Inhibition of renninangiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats显示文摘 | Yoshiji H Yoshii J Ikenaka Y | 2002 | J Hepatol2002，37，1： | 1 |
| 20 | Tissue inhibitor of metalloproteinase-1(TIMP-1) inhibits tumor growth and angiogenesis in the TIMP-1transgenic mouse model显示文摘 | Ikenaka Y Yoshi H Kuriyamas | 2003 | Cancer2003，105，3： | 1 |
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