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您的检索式：作者名="Ikram M.K."
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| 1 | 视网膜血管直径与卒中风险的关系:鹿特丹研究显示文摘Background: Retinal vessels may provide information on cerebral vascular pathology, because they share many features with cerebral vessels. A smaller ratio of the retinal arteriolar-to-venular diameters reportedly predicts the risk of stroke. It is unclear if this is due to arteriolar narrowing or venular dilation. Objective: To investigate whether smaller arteriolar or larger venular diameters are related to the risk of stroke and cerebral infarction. Methods: This study was based on the prospective population-based Rotterdam Study and included 5,540 participants of 55 years or over, who had gradable fundus transparencies and were free of stroke at baseline (1990 to 1993). For each participant, retinal arteriolar and venular diameters were measured on digitized images of one eye. Follow-up for first-ever stroke was complete until January 1, 2002. Results: After a mean follow-up of 8.5 years, 411 participants had a stroke, of whom 259 had cerebral infarction. Larger venular diameters were associated with an increased risk of stroke (hazard ratio [HR] adjusted for age and sex per SD increase: 1.12 [95%CI: 1.02 to 1.24]) and cerebral infarction (HR: 1.15 [95%CI: 1.02 to 1.29]). Smaller arteriolar diameters were neither related to the risk of stroke (HR per SD decrease: 1.02 [95%CI: 0.93 to 1.13]) nor to the risk of cerebral infarction (HR: 1.02 [95%CI: 0.90 to 1.15]). After additional adjustment for other cardiovascular risk factors, the results did not change. Conclusions: Larger retinal venular diameters are associated with an increased risk of stroke and cerebral infarction. The role of venules in cerebrovascular disease warrants further exploration. | Ikram M.K. De Jong F.J. Bos M.J. P.T.V.M. De Jong 邱伟庆 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 4 |
| 2 | 视网膜血管直径与脑卒中的风险:来自鹿特丹的研究显示文摘Background:Retinal vessels may provide information on cerebral vascular pathology,because they share many features with cerebral vessels.A smaller ratio of the retinal arteriolar-to-venular diameters reportedly predicts the risk of stroke.It is unclear if this is due to arteriolar narrowing or venular dilation.Objective:To investigate whether smaller arteriolar or larger venular diameters are related to the risk of stroke and cerebral infarction.Methods:This study was based on the prospective population-based Rotterdam Study and included 5,540 participants of 55 years or over,who had gradable fundus transparencies and were free of stroke at baseline(1990 to 1993).For each participant,retinal arteriolar and venular diameters were measured on digitized images of one eye.Follow-up for first-ever stroke was complete until January 1,2002.Results:After a mean follow-up of 8.5 years,411 participants had a stroke,of whom 259 had cerebral infarction.Larger venular diameters were associated with an increased risk of stroke(hazard ratio HR adjusted for age and sex per SD increase:1.12 95% CI:1.02 to 1.24)and cerebral infarction(HR:1.15 95% CI:1.02 to 1.29).Smaller arteriolar diameters were neither related to the risk of stroke(HR per SD decrease:1.02 95% CI:0.93 to 1.13)nor to the risk of cerebral infarction(HR:1.02 95% CI:0.90 to 1.15).After additional adjustment for other cardiovascular risk factors,the results did not change.Conclusions:Larger retinal venular diameters are associated with an increased risk of stroke and cerebral infarction.The role of venules in cerebrovascular disease warrants further exploration. | Ikram M.K. De Jong F.J. Bos M.J. 桑延智 | 2006 | 世界核心医学期刊文摘(眼科学分册)2006，2，9： | 2 |
| 3 | Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan Study显示文摘 | M.K. Ikram F.J. De Jong E.J. Van Dijk N.D. Prins A. Hofman M.M. Breteler | 2006 | American Journal of Ophthalmology2006，，： | 1 |
| 4 | 视网膜血管直径与散发性老年性黄斑病变发病的危险性:鹿特丹研究 | Ikram M.K. Van Leeuwen R. Vingerling J.R. P.T.V.M. De Jong 张鹏 | 2005 | 世界核心医学期刊文摘(眼科学分册)2005，0，11： | 0 |
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