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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Phase Ⅱ trial of 17 - allylamino - 17 - demethoxygeldanamycin in patients with metastatic melanoma 显示文摘 | David B Solitl Iman Osman David Polsky | 2008 | Clin Cancer Res2008，14，： | 1 |
| 3 | Effect of annealing twins on Hall-Perch relation in polycrystalline materials显示文摘 | PANDE C S RATH B B IMAN M A | 2004 | Mater Sci Eng A2004，367，： | 1 |
| 4 | Lithologic characteristics and diagenesis of the Devonian Jauf sandstone at Ghawar Field, Eastern Saudi Arabia显示文摘 | AI-Ramadan K A Hussain M Iman B | 2004 | Marine and Petroleum Geology2004，21，10： | 1 |
| 5 | Magnesium perchlorate as a new and highly efficient catalyst for the synthesis of 2,3-dihydro-1,5-benzo thiazepines显示文摘 | Kiumars B Mohammad Mehdi K Iman K | 2007 | Synthesis2007，，4： | 1 |
| 6 | Investigation of corrosion performance of epoxy coating containing polyaniline nanoparticles显示文摘 | Niloufar B P Mahmood P Iman D | 2012 | Iranian Polymer Journal2012，21，11： | 1 |
| 7 | Effect of Increased Tea Consumption on Oxidative DNA Damage among Smokers: A Randomized Controlled Study 显示文摘 | Iman A Hakim Robin B Harris Sylvia Brown | 2003 | J Nutr2003，133，： | 1 |
| 8 | En- gaging older adults in their transitional care: what more needs to be done显示文摘 | NAYLOR M D HIRSC/-IMAN K B O'CONNOR M | 2013 | J Comp Eft Res2013，2，5： | 1 |
| 9 | Alphamelanocytestimulating hormone regulation of tyrosinase in Cloudman S91 mouse melanoma cell cultures 显示文摘 | FULLER B B LUNSFORD J B IMAN D S | 1987 | J Biol Chem1987，262，： | 1 |
| 10 | Applying Shared-parking Turn- time (SPATT) Model and Geographic Information System in the Supply and Demand Analysis of Park- ing Space显示文摘 | IMAN M HAMID B | 2006 | Malaysian Journal of Real Estate2006，1，2： | 1 |
| 11 | High-dose treatment with lanreotide of patients with advanced neuroendonrine gastrointestinal tumors:clinical and biological effects显示文摘 | Eriksson B Renstrup J Iman H | 1997 | Ann Oncol1997，8，10： | 1 |
| 12 | Alpha- melanocyte- stimulating hormone regulation of tyrosinase in cloudman S - 91 mouse melanoma cell culture 显示文摘 | Fuller B B Lunsford J B Iman D S | 1987 | J Biol Chem1987，262，： | 1 |
| 13 | Airway remodeling in asthma; New mechanisms and potential for pharmacological intervention显示文摘 | Pierre OG Annaig O Imane B | 2011 | Pharmacology Therapeutics2011，130，3： | 1 |
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