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2篇 您的检索式:作者名="In Youb Chang"
    题名 作者 年代 出处 被引量
1Identification of TRPM7 channels in human intestinal interstitial cells of Cajal显示文摘AIM:To investigate the characteristics of slow elec-trical waves and the presence of transient receptor potential melastatin-type 7(TRPM7)in the human gas-trointestinal(GI)tract.METHODS:Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue.Immunohisto-chemistry was used to identify TRPM7 channels in in-terstitial cells of Cajal(ICCs).RESULTS:The human GI tract generated slow electri-cal waves and had ICCs which functioned as pacemak-er cells.Flufenamic acid,a nonselective cation channel blocker,and 2-APB(2-aminoethoxydiphenyl borate)and La3+,TRPM7 channel blockers,inhibited the slowwaves.Also,TRPM7 channels were expressed in ICCs in human tissue.CONCLUSION:These results suggest that the human GI tract generates slow waves and that TRPM7 chan-nels expressed in the ICCs may be involved in the gen-eration of the slow waves.Byung Joo Kim Kyu Joo Park Hyung Woo Kim Seok Choi Jae Yeoul Jun In Youb Chang Ju-Hong Jeon Insuk So Seon Jeong Kim 2009World Journal of Gastroenterology2009,15,46:3
2Melastatin-Type Transient Receptor Potential Channel 7 Is Required for Intestinal Pacemaking Activity显示文摘Byung Joo Kim Hyun–Ho Lim Dong Ki Yang Jae Yeoul Jun In Youb Chang Chul–Seung Park Insuk So Peter R. Stanfield Ki Whan Kim 2005Gastroenterology2005,,5:1
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