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| 1 | TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancer显示文摘BACKGROUND Patients with stage II-III colorectal cancer (CRC) treated with adjuvant chemotherapy, gain a 25% survival benefit. In the context of personalized medicine, there is a need to identify patients with CRC who may benefit from adjuvant chemotherapy. Molecular profiling could guide treatment decisions in these patients. Thymidylate synthase (TYMS) gene polymorphisms, KRAS and BRAF could be included in the molecular profile under consideration. AIM To investigate the association of TYMS gene polymorphisms, KRAS and BRAF mutations with survival of CRC patients treated with chemotherapy.METHODS A retrospective study studied formalin-fixed paraffin-embedded tissues (FFPEs) of consecutive patients treated with adjuvant chemotherapy during January/2005-January/2007. FFPEs were analysed with PCR for the detection of TYMS polymorphisms, mutated KRAS (mKRAS) and BRAF (mBRAF). Patients were classified into three groups (high, medium and low risk) according to 5’UTR TYMS polymorphisms Similarly, based on 3’UTR polymorphism ins/loss of heterozygosity (LOH) patients were allocated into two groups (high and low risk of relapse, respectively). Cox regression models examined the associated 5- year survival outcomes. RESULTS One hundred and thirty patients with early stage CRC (stage I-II: 55 patients;stage III 75 patients;colon: 70 patients;rectal: 60 patients) were treated with surgery and chemotherapy. The 5-year disease free survival and overall survival rate was 61.6% and 73.9% respectively. 5’UTR polymorphisms of intermediate TYMS polymorphisms (2RG/3RG, 2RG/LOH, 3RC/LOH) were associated with lower risk for relapse [hazard ratio (HR) 0.320, P = 0.02 and HR 0.343, P = 0.013 respectively] and death (HR 0.368, P = 0.031 and HR 0.394, P = 0.029 respectively). The 3’UTR polymorphism ins/LOH was independently associated with increased risk for disease recurrence (P = 0.001) and death (P = 0.005). mBRAF (3.8% of patients) was associated with increased risk of death (HR 4.500, P = 0.022) whereas mKRAS (39% of patients) not. CONCLUSION Prospective validating studies are required to confirm whether 2RG/3RG, 2RG/LOH, 3RC/LOH, absence of ins/LOH and wild type BRAF may indicate patients at lower risk of relapse following adjuvant chemotherapy. | Anastasios Ntavatzikos Aris Spathis Paul Patapis Nikolaos Machairas Georgia Vourli George Peros Iordanis Papadopoulos Ioannis Panayiotides Anna Koumarianou | 2019 | World Journal of Gastrointestinal Oncology2019，11，7： | 5 |
| 2 | Brain Volume and Neurobehavior in Newborns with Complex Congenital Heart Defects显示文摘 | Mallory Owen Michael Shevell Mary Donofrio Annette Majnemer Robert McCarter Gilbert Vezina Marine Bouyssi-Kobar Iordanis Evangelou Dena Freeman Neil Weisenfeld Catherine Limperopoulos | 2013 | The Journal of Pediatrics2013，，： | 1 |
| 3 | Optimizing Performance in Current- Controlled Switched Reluctance Generators显示文摘 | Christos Mademlis Iordanis Kioskeridis | 2014 | 1EEE Transactions on Energy Conversion2014，3，20： | 1 |
| 4 | Normal aging does not deteriorate nose-related quality of life: assessment with 'NOSE' and 'SNOT-20' questionnaires 显示文摘 | Jocrg Lindemann Evangelia Tsakiropoulou Iordanis Konstantinidis | 2010 | Auris Nasus Larynx2010，37，3： | 1 |
| 5 | Loss Minimization in Induction Motor Adjustable-speed Drives 显示文摘 | IORDANIS KIOSKERIDIS | 1996 | IEEE TRANS on Industry Application1996，43，1： | 1 |
| 6 | Thermal and slip effects on rotor time constant in vector controlled induction motor drives显示文摘 | Constantine Mastorocostas Iordanis Kioskeridis Nikos Margaris | 2006 | IEEE Transactions on Power Electronics2006，21，2： | 1 |
| 7 | How do children with adenoid hypertrophy smell and taste?显示文摘 | Iordanis Konstantinidis Stefanos Triaridis Athanasios Triaridis Ioannis Petropoulos Konstantinos Karagiannidis George Kontzoglou | 2005 | International Journal of Pediatric Otorhinolaryngology2005，，： | 1 |
| 8 | Process versus Product Innovation in Multiproduct Firms显示文摘 | Iordanis Petsas Christos Giannikos | 2005 | International Journal of Business and Economics2005，4，3： | 1 |
| 9 | Volume-to-capacity ratio and traffic accident on interurban four-lane highways in greece显示文摘 | FRANTZESKAKIS J M IORDANIS D I | 1987 | Transportation Research Record1987，1112，： | 1 |
| 10 | miR-224 overexpression is a strong and independent prognosticator ofshort-term relapse and poor overall survival in colorectal adenocarcinoma显示文摘 | Panagiotis Adamopoulos Christos Kontos Stamatia-Maria Rapti Iordanis Papadopoulos Andreas Scorilas | 2015 | International Journal of Oncology2015，，： | 1 |
| 11 | Cell-type-depend- ent thyroid hormone effects on glioma tumor cell lines显示文摘 | Alexandms L Iordanis M Athanasios Z | 2011 | J Thy- roid Res2011，2011，： | 1 |
| 12 | Thyroid hormone is a critical determinant of myocardial performance in patients with heart failure: potential therapeutic implications 显示文摘 | Constantinos Pantos Athanasios Dritsas Iordanis Mourouzis etal | 2007 | European Journal of Endocrinology2007，157，4： | 1 |
| 13 | Cytokine changes after surgical treatment of obstructive sleep apnoea syndrome显示文摘 | Jannis Constantinidis Stefanos Ereliadis Nikolaos Angouridakis Iordanis Konstantinidis Victor Vital Christina Angouridaki | 2008 | European Archives of Oto - Rhino - Laryngology2008，，10： | 1 |
| 14 | A structured autopsy- based audit of 370 firearm fatalities : Contribution to inform policy decisions and the probability of the injured arriving alive at a hospital and receiving de- finitive care 显示文摘 | Iordanis P Nikolaos K Nikolaos D | 2013 | Aceid Anal Prey2013，50，6： | 1 |
| 15 | A Comprehensive Evaluation Framework for Hotel Websites:The Case of Chain Hotel Websites Operating in Greece显示文摘 | Alkiviadis Panagopoulos Dimitris Kanellopoulos Iordanis Karachanidis | 2011 | Journal of Hospitality Marketing&Management2011，，7： | 1 |
| 16 | Process versus Product Innovation in Multiproduct Firms 显示文摘 | Iordanis Petsas Christos Giannikos | 2005 | International Journal of Business and Economics2005，4，3： | 1 |
| 17 | Optimal efficiency control strategy for interior permanent magnet synchronous motor drives 显示文摘 | Christos Mademlis Iordanis Kioskeridis Nikos Margaris | 1999 | IEEE Transactions on Energy Conversion1999，，14： | 1 |
| 18 | Quantitative expression analysis and prognostic significance of the novel apoptosis-related gene BCL2L12 in colon cancer显示文摘 | Christos K. Kontos Iordanis N. Papadopoulos Andreas Scorilas | 2008 | Biological Chemistry2008，，12： | 1 |
| 19 | Nipple discharge screening显示文摘 | Stefanos Zervoudis Georgos Iatrakis Panagiotis Economides Demetrios Polyzos Iordanis Navrozoglou | 2010 | Women’s Health2010，，1： | 1 |
| 20 | Thyroid hormone as a therapeutic option for treating ischaemic heart disease: From early reperfusion to late remodelling显示文摘 | Constantinos P Iordanis M Dennis VC | 2010 | Vasc Pharmacol2010，52，34： | 1 |
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