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| 1 | Pathways of flower infection and pollen-mediated dispersion of Pseudomonas syringae pv. actinidiae, the causal agent of kiwifruit bacterial canker显示文摘Flowers can provide a protected and nutrient-rich environment to the epiphytic microflora,thus representing a sensible entry point for pathogens such as Pseudomonas syringae pv.actinidiae(Psa).This bacterium can colonize both male and female Actinidia flowers,causing flower browning and fall,and systemic invasion of the host plant,eventually leading to its death.However,the process of flower colonization and penetration into the host tissues has not yet been fully elucidated.In addition,the presence of Psa in the pollen from infected flowers,and the role of pollination in the spread of Psa requires confirmation.The present study employed a Psa strain constitutively expressing the fluorescent GFPuv protein,to visualize in vivo flower colonization.Microscopy observations were performed by means of confocal laser scanning and wide-field fluorescent microscopy,and were coupled with the study of Psa population dynamics by quantitative PCR(q-PCR).The pathogen was shown to colonize stigmata,move along the stylar furrow,and penetrate the receptacles via the style or nectarhodes.Once the receptacle was invaded,the pathogen migrated along the flower pedicel and became systemic.Psa was also able to colonize the anthers epiphytically and endophytically.Infected male flowers produced contaminated pollen,which could transmit Psa to healthy plants.Finally,pollinators(Apis mellifera and Bombus terrestris)were studied in natural conditions,showing that,although they can be contaminated with Psa,the pathogen’s transmission via pollinators is contrasted by its short survival in the hive. | Irene Donati Antonio Cellini Giampaolo Buriani Sofia Mauri Callum Kay Gianni Tacconi Francesco Spinelli | 2018 | Horticulture Research2018，5，1： | 3 |
| 2 | Reverse time-dependent effect of alphafetoprotein and disease control on survival of patients with Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma显示文摘AIM To characterize the survival of cirrhotic patients with Barcelona Clinic Liver Cancer(BCLC) stage C hepatocellular carcinoma(HCC) and to ascertain the factors predicting the achievement of disease control(DC).METHODS The cirrhotic patients with BCLC stage C HCC evaluated by the Hepatocatt multidisciplinary group were subjected to the investigation. Demographic, clinical and tumor features, along with the best tumor response and overall survival were recorded. RESULTS One hundred and ten BCLC stage C patients were included in the analysis; the median overall survival was 13.4 mo(95%CI: 10.6-17.0). Only alphafetoprotein(AFP) serum level > 200 ng/m L and DC could independently predict survival but in a time dependent manner, the former was significantly associated with increased risk of mortality within the first 6 mo of follow-up(HR = 5.073, 95%CI: 2.159-11.916, P = 0.0002), whereas the latter showed a protective effect against death after one year(HR = 0.110, 95%CI: 0.038-0.314, P < 0.0001). Only patients showing microvascular invasion and/or extrahepatic spread recorded lower chances of achieving DC(OR = 0.263, 95%CI: 0.111-0.622, P = 0.002).CONCLUSION The BCLC stage C HCC includes a wide heterogeneous group of cirrhotic patients suitable for potentially curative treatments. The reverse and time dependent effect of AFP serum level and DC on patients' survival confers them as useful predictive tools for treatment management and clinical decisions. | Francesca Romana Ponziani Irene Spinelli Emanuele Rinninella Lucia Cerrito Antonio Saviano Alfonso Wolfango Avolio Michele Basso Luca Miele Laura Riccardi Maria Assunta Zocco Brigida Eleonora Annicchiarico Matteo Garcovich Marco Biolato Giuseppe Marrone Anna Maria De Gaetano Roberto Iezzi Felice Giuliante Fabio Maria Vecchio Salvatore Agnes Giovanni Addolorato Massimo Siciliano Gian Lodovico Rapaccini Antonio Grieco Antonio Gasbarrini Maurizio Pompili | 2017 | World Journal of Hepatology2017，9，36： | 1 |
| 3 | 肝脏复合病变:伴局灶性结节增生的炎性肝细胞息肉显示文摘Introduction Focal nodular hyperplasia(FNH)and hepatocellular adenoma(HCA)are both benign nodular hepatocellular lesions.FNH is the second-most common solid liver tumour,representing8%of all primary hepatic neoplasms[1].If the diagnosis of FNH is firmly established on the basis of imaging,and if the individual is asymptomatic,follow-up imaging is not required,and the patient can be discharged.However,there is a poor association between FNH and symptoms;therefore,even in symptomatic cases,treatment is rarely indicated[2]. | Matteo Renzulli Irene Pettinari Francesco Vasuri Matteo Ravaioli Beniamino Corcioni Daniele Spinelli Giovanni Marasco Matteo Cescon Antonietta D’Errico Rita Golfieri | 2021 | Gastroenterology Report2021，9，4： | 0 |
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