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| 1 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 2 | Herpes Simplex Virus Type 1/adeno-associated Virus Hybrid Vectors Mediated Site-specific Integration at the Adeno-associated Virus Preitegration Site, AAVS1, on Human Chromosome 19显示文摘 | Irma H Mathias A | 2002 | Journal of Virology2002，76，： | 1 |
| 3 | Seroprevalence and national distribution of human toxoplasmosis in Mexico: analysis of the 2000 and 2006 National Health Surveys显示文摘 | Heriberto Caballero-Ortega Felipe Javier Uribe-Salas Carlos J. Conde-Glez Carlos Cedillo-Pelaez José Antonio Vargas-Villavicencio Héctor Luna-Pastén Irma Ca?edo-Solares Luz Belinda Ortiz-Alegría Dolores Correa | 2012 | Transactions of the Royal Society of Tropical Medicine and Hygiene2012，，11： | 1 |
| 4 | Comparative HPLC enantioseparation of new chiral hydantoin derivatives on three different polysaccharide type chiral stationary phases显示文摘 | IRMA K MARTIAL K THIERRY H | 2002 | J Pharm Biomed Anal2002，27，3： | 1 |
| 5 | Competitiveness of nations: a knowledge discovery examination显示文摘 | Stelios H Zanakis Irma Beeerra-Femandez | 2005 | European Journal of Operational Research2005，，166： | 1 |
| 6 | Indication for CDKN2A-mutation analysis in familial pancreatic cancer families without melanomas显示文摘 | Femme Harinck Irma Kluijt Nienke van der Stoep Rogier A Oldenburg Anja Wagner Cora M Aalfs Rolf H Sijmons Jan-Werner Poley Ernst J Kuipers Paul Fockens Theo A M van Os Marco J Bruno | 2012 | Journal of Medical Genetics2012，，6： | 1 |
| 7 | Competitiveness of Nations: A Knowledge Discovery Examination显示文摘 | Stelios H Zanakis Irma Becerra-Fernandez | 2005 | European Journal of Operational Research2005，，166： | 1 |
| 8 | Distinctive anti-allergy properties oftwo probiotic bacterial strains in a mouse model of allergicpoly-sensitization显示文摘 | Irma S Karin H | 2011 | Vaccine2011，，29： | 1 |
| 9 | Genetic testing for reti- nal dystrophies and dysfunctions:benefits, dilemmas and solu- tions显示文摘 | Robert K K Irma L den Anneke I H et aI | 2007 | Clinical and Experimental Ophthalmology2007，35，5： | 1 |
| 10 | Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy显示文摘 | Huiling Li Isabelle Romieu Hao Wu Juan-Jose Sienra-Monge Matiana Ramírez-Aguilar Blanca Estela Río-Navarro Irma Carmen Lara-Sánchez Emily O. Kistner H?kon K. Gjessing Stephanie J. London | 2007 | Human Genetics2007，，5： | 1 |
| 11 | Comparative HPLC enantioseparation of new chiral hydantoin derivatives on three different polysaccharide type chiral stationary phases显示文摘 | Irma K Martial K Thierry H | 2002 | Pharm Biomed Anal2002，27，34： | 1 |
| 12 | An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons显示文摘 | Esther F.A Brandon Christiaan D Raap Irma Meijerman Jos H Beijnen Jan H.M Schellens | 2003 | Toxicology and Applied Pharmacology2003，，3： | 1 |
| 13 | Parental rearing styles and personality disorders in prisoners and forensic patients显示文摘 | Irma G H Timmerman P M G E | 2005 | Clinical Psychology & Psychotherapy2005，12，3： | 1 |
| 14 | Atlas and histologie classification of tumors of the rat mammary gland 显示文摘 | Russo J Irma H | 2000 | J Mammary Gland Biol Neoplasia2000，5，2： | 1 |
| 15 | Empirical anticoagulation for patients in sinus rhythm at high risk of ischaemic stroke:A review of current literature显示文摘Ischaemic stroke is one of the commonest causes of morbidity and mortality worldwide and around a fifth of events can be attributed to a cardioembolic source. This is typically due to atrial fibrillation(AF), the most common sustained cardiac arrhythmia. However, AF can, at times, be difficult to detect due to a relative lack of symptoms and the fact that it can be paroxysmal in nature. Studies have shown that diagnosis of AF improves as the length of cardiac monitoring increases. However, prolonged cardiac monitoring is not a costeffective way of diagnosing AF. Therefore, an alternative approach may be to empirically anticoagulate individuals who are at high risk of stroke. This article summarises current evidence surrounding stroke risk prediction, the use of anticoagulation in the secondary prevention of stroke and its use in the primary prevention of stroke in high risk groups with the aim of determining whether empirical anticoagulation is a safe and effective strategy. | Irma Battipaglia James O'Neill Andrew J Hogarth Muzahir H Tayebjee | 2017 | World Journal of Cardiology2017，9，5： | 0 |
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