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| 1 | The Immune System and the Role of Inflammation in Perinatal Depression显示文摘Major depression during pregnancy is a common psychiatric disorder that arises from a complex and multifactorial etiology. Psychosocial stress, sex, hormones, and genetic vulnerability increase the risk for triggering mood disorders. Microglia and toll-like receptor 4 play a crucial role in triggering wide and varied stress-induced responses mediated through activation of the inflammasome; this leads to the secretion of inflammatory cytokines, increased serotonin metabolism, and reduction of neurotransmitter availability along with hypothalamic–pituitary–adrenal axis hyperactivity. Dysregulation of this intricate neuroimmune communication network during pregnancy modifies the maternal milieu, enhancing the emergence of depressive symptoms and negative obstetric and neuropsychiatric outcomes. Although several studies have clearly demonstrated the role of the innate immune system in major depression, it is still unclear how the placenta, the brain, and the monoaminergic and neuroendocrine systems interact during perinatal depression. Thus, in the present review we describe the cellular and molecular interactions between these systems in major depression during pregnancy, proposing that the same stress-related mechanisms involved in the activation of the NLRP3 inflammasome in microglia and peripheral myeloid cells in depressed patients operate in a similar fashion in the neuroimmune placenta during perinatal depression. Thus, activation of Toll-like receptor 2 and 4 signaling and the NLRP3 inflammasome in placental immune cells may promote a shift of the Th1/Th2 bias towards a predominant Th1/Th17 inflammatory response, associated with increased secretion of pro-inflammatory cytokines, among other secreted autocrine and paracrine mediators, which play a crucial role in triggering and/or exacerbating depressive symptoms during pregnancy. | Philippe Leff-Gelman Ismael Mancilla-Herrera Monica Flores-Ramos Carlos Cruz-Fuentes Juan Pablo Reyes-Grajeda maría del pilar garcía-cuétara Marielle Danitza Bugnot-Perez David Ellioth Pulido-Ascencio | 2016 | Neuroscience Bulletin2016，32，4： | 17 |
| 2 | 为胃的倒空和活动性评估的电的 bioimpedance 和另外的技术显示文摘 The aim of this article is to identify non-invasive, inexpensive, highly sensitive and accurate techniques for evaluating and diagnosing gastric diseases. In the case of the stomach, there are highly sensitive and specific methods for assessing gastric motility and emptying (GME). However, these methods are invasive, expensive and/or not technically feasible for all clinicians and patients. We present a summary of the most relevant international information on non-invasive methods and techniques for clinically evaluating GME. We particularly emphasize the potential of gastric electrical bioimpedance (EBI). EBI was initially used mainly in gastric emptying studies and was essentially abandoned in favor of techniques such as electrogastrography and the gold standard, scintigraphy. The current research evaluating the utility of gastric EBI either combines this technique with other frequently used techniques or uses new methods for gastric EBI signal analysis. In this context, we discuss our results and those of other researchers who have worked with gastric EBI. In this review article, we present the following topics: (1) a description of the oldest methods and procedures for evaluating GME; (2) an explanation of the methods currently used to evaluate gastric activity; and (3) a perspective on the newest trends and techniques in clinical and research GME methods. We conclude that gastric EBI is a highly effective non-invasive, easy to use and inexpensive technique for assessing GME. | María Raquel Huerta-Franco Miguel Vargas-Luna Juana Berenice Montes-Frausto Corina Flores-Hernández Ismael Morales-Mata | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，1： | 5 |
| 3 | Effect of psychological stress on gastric motility assessed by electrical bio-impedance显示文摘AIM:To evaluate gastric motility using electrical bioimpedance(EBI) and gastric changes as a result of stress induced by psychological tests.METHODS:A group of 57 healthy women,aged 40-60 years,was recruited,and a clinical history and physical examination were performed.The women were free from severe anxiety,chronic or acute stress,severe depression,mental diseases and conditions that affect gastric activity.The women were evaluated under fasting conditions,and using a four-electrode configuration,the gastric signals were obtained through a BIOPAC MP-150 system.The volunteers were evaluated using the following paradigm:basal state,recording during the Stroop Test,intermediate resting period,recording during the Raven Test,and a final resting period.We analyzed the relative areas of the frequency spectrum:A1(1-2 cpm),A2(2-4 cpm),A3(4-8 cpm),and A4(8-12 cpm),as well as the median of area A2 + A3.The data were analyzed by an autoregressive method using a Butterworth filter with MatLab and Origin.Analysis of variance(ANOVA) and Friedman ANOVA(for nonparametric variables) were performed;in addition,pairs of groups were compared using the T dependent and Wilcoxon T tests.RESULTS:The results of the main values of area A2 were not significantly different comparing the five steps of the experimental paradigm.Nevertheless,there was a tendency of this A2 region to decrease during the stress tests,with recuperation at the final resting step.When an extended gastric region was considered(1-4 cpm),significant differences with the psychological stress tests were present(F = 3.85,P = 0.005).The A3 region also showed significant changes when the stress psychological tests were administered(F = 7.25,P < 0.001).These differences were influenced by the changes in the adjacent gastric region of A2.The parameter that we proposed in previous studies for the evaluation of gastric motility by electrical bio-impedance(EBI) was the median of the area under the region from 2 to 8 cpm(A2 + A3).The mean values of these frequencies(median of the A2 + A3 area) with the stress test showed significant changes(F = 5.5,P < 0.001).The results of the WilcoxonT test for the A4 area parameter,which is influenced by the breathing response,changed significantly during the Raven stress test(P < 0.05).CONCLUSION:We confirm that the gastric response to acute psychological stress can be evaluated by short-term EBI. | María Raquel Huerta-Franco Miguel Vargas-Luna Juana Berenice Montes-Frausto Ismael Morales-Mata Lorena Ramirez-Padilla | 2012 | World Journal of Gastroenterology2012，18，36： | 5 |
| 4 | Efficacy and Safety of Anticoagulation on Patients With Cirrhosis and Portal Vein Thrombosis显示文摘 | María Gabriela Delgado Susana Seijo Ismael Yepes Linette Achécar Maria Vega Catalina ángeles García–Criado Juan G. Abraldes Joaquín de la Pe?a Rafael Ba?ares Agustín Albillos Jaume Bosch Juan Carlos García–Pagán | 2012 | Clinical Gastroenterology and Hepatology2012，，7： | 3 |
| 5 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 6 | Long-term evaluation of biliary reconstruction after partial resection of segments IV and V in iatrogenic injuries显示文摘 | Miguel ángel Mercado M.D. Carlos Chan M.D. Héctor Orozco M.D. José M. Villalta M.D. Alexandra Barajas-Olivas M.D. Javier Era?a M.D. Ismael Domínguez M.D | 2006 | Journal of Gastrointestinal Surgery2006，，1： | 3 |
| 7 | Antihypertensive and vasorelaxant effects of tilianin isolated from Agastache mexicana are mediated by NO/cGMP pathway and potassium channel opening显示文摘 | Oswaldo Hernández-Abreu Patricia Castillo-Espa?a Ismael León-Rivera Maximiliano Ibarra-Barajas Rafael Villalobos-Molina Judith González-Christen Jorge Vergara-Galicia Samuel Estrada-Soto | 2009 | Biochemical Pharmacology2009，，1： | 2 |
| 8 | Recovery of phenol from aqueous solutions using liquid membranes with cyanex 923显示文摘 | Reis M T A De freitas O M Ismael M R C | 2007 | J Membrane Sci2007，305，1： | 1 |
| 9 | The MIC3 gene of toxoplasma gondii is a novel potent vaccine candidate against toxoplasmosis显示文摘 | ISMAEL A B SEKKAI D | 2003 | Infect Inmmu2003，71，11： | 1 |
| 10 | RUNX1 mutation associated with elonal evolution in relapsed pediatrie acute myeloid leukemia with t(16;21) (p11 ;q22) 显示文摘 | Ismael O Shimada A Elmahdi S | 2014 | Int J Hematol2014，99，2： | 1 |
| 11 | ALOE : an open-source SDR execution environment with cognitive computing resource management capabilities显示文摘 | Ismael G Marojevic V Gelonch A | 2011 | IEEE Communications Magazine2011，49，9： | 1 |
| 12 | Expression of toll-like receptor 2 on peripheral blood monocytes of patients withinflammatory and noninflammatory acne vulgaris显示文摘 | Fathy A Mohamed RW Ismael NA | 2009 | Egypt J Im-munol2009，16，1： | 1 |
| 13 | Geotechnical properties of oil-contaminated Kuwait sand 显示文摘 | AL-SANAD H A EID W K ISMAEL N F | 1995 | Journal of Geotechnical Engineering1995，121，5： | 1 |
| 14 | Aging effect on oil contaminated Kuwaiti sand 显示文摘 | Alsanad H A Ismael N F | 1997 | Journal of Geoteehnieal and Geoenvironmental Engineering1997，123，33： | 1 |
| 15 | Aging effect on oil-contaminated Kuwait sand 显示文摘 | AL-SANAD H A ISMAEL N F | 1997 | Journal of Geotechnical and Geoenvironmental Engineering1997，123，3： | 1 |
| 16 | Development of a mobile-system based on laser-induced breakdown spectroscopy and dedicated to in situ analysis of polluted soils显示文摘 | Bousquet B Travaille G Ismael A | 2008 | Spectrochimica Acta Part B2008，63，10： | 1 |
| 17 | The MIC3 gene of Toxoplasma gondii is a novel potent vaccine candidate against toxoplasmosis显示文摘 | Ismael A B Sekkai D Collin C | 2003 | Infect Immun2003，71，11： | 1 |
| 18 | Colonization of intensive care unit patients by pesudoomonas aeruginsa显示文摘 | ISMAEL N A | 1993 | J Hospi Infect1993，25，4： | 1 |
| 19 | Recovery of phenol from aqueous solutions using liquid membranes with Cyanex 923 显示文摘 | Reis M T A Freitas O M F Ismael M R C | 2007 | Journal of Membrane Science2007，305，12： | 1 |
| 20 | Ferric sulphate/chloride leaching of zinc and minor elements from a sphalerite concentrate显示文摘 | SANTOS S M C MACHADO R M CORREIA M J N REIS M T A ISMAEL M R C CARVALHO J M R | 2010 | Minerals Engineering2010，23，8： | 1 |
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