|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis显示文摘AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy.METHODS We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were used.RESULTS A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were reported.CONCLUSION In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course. | Animesh Jain Evan J Lipson William H Sharfman Steven R Brant Mark G Lazarev | 2017 | World Journal of Gastroenterology2017，23，11： | 8 |
| 3 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 4 | Association of overexpression of TIF1γ with colorectal carcinogenesis and advanced colorectal adenocarcinoma显示文摘AIM:To determine the expression and clinical significance of transcriptional intermediary factor 1 gamma (TIF1γ),Smad4 and transforming growth factor-beta (TGFβR) across a spectrum representing colorectal cancer (CRC) development.METHODS:Tissue microarrays were prepared from archival paraffin embedded tissue,including 51 colorectal carcinomas,25 tubular adenomas (TA) and 26 HPs,each with matched normal colonic epithelium.Immunohistochemistry was performed using antibodies against TIF1γ,Smad4 and TGFβ RⅡ.The levels of expression were scored semi-quantitatively (score 0-3 or loss and retention for Smad4).RESULTS:Overexpression of TIF1γ was detected in 5/26 (19%) HP;however,it was seen in a significantly higher proportion of neoplasms,15/25 (60%) TAs and 24/51 (47%) CRCs (P<0.05).Normal colonic mucosa,HP,and TAs showed strong Smad4 expression,while its expression was absent in 22/51 (43%) CRCs.Over-expression of TGFβ RⅡ was more commonly seen in neoplasms,13/25 (52%) TAs and 29/51 (57%) CRCs compared to 9/26 (35%) HP (P<0.05).Furthermore,there was a correlation between TIF1γ overexpression and Smad4 loss in CRC (Kendall tau rank correlation value=0.35,P<0.05).The levels of TIF1γ overexpression were significantly higher in stage Ⅲ than in stage Ⅰ and Ⅱ CRC (P<0.05).CONCLUSION:The findings suggest that over-expression of TIF1γ occurs in early stages of colorectal carcinogenesis,is inversely related with Smad4 loss,and may be a prognostic indicator for poor outcome. | Shilpa Jain Shashideep Singhal Franto Francis Cristina Hajdu Jin-Hua Wang Arief Suriawinata Yin-Quan wang Miao Zhang Elizabeth H Weinshel Fritz Francois Zhi-Heng Pei Peng Lee Ru-Liang Xu | 2011 | World Journal of Gastroenterology2011，17，35： | 3 |
| 5 | Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infaretion显示文摘 | Jain M DerSimonian H Brenner DA | 2001 | Circulation2001，103，： | 1 |
| 6 | Antidiabetie effect of probiotie dalai containing Laetobaeillus aeidophilus and Laetobaeillus casei in high fructose fed rats显示文摘 | YADAV H JAIN S | 2006 | Nutrition2006，41，6： | 1 |
| 7 | Muhidrug resistant acinetobacter in fections: an emerg ng challenge to clinicians显示文摘 | Jain R Danziger L H | 2004 | Ann Pharm acother2004，38，9： | 1 |
| 8 | Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction显示文摘 | Jain M Dersimonian H Brenner DA | 2001 | Circulation2001，103，： | 1 |
| 9 | Cell therapy anenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction显示文摘 | Jain M DerSimonian H Brenner DA | 2001 | Circulation2001，103，14： | 1 |
| 10 | Cell therapy attenuates deleterious ventricular remodeling and improve cardiac performance after myocardial infarction显示文摘 | JAIN M DERASIMONIAN H DANIEL A | 2001 | Circulation2001，103，： | 1 |
| 11 | Arsenite and arsenate adsorption on ferrihydrite:surface charge reduction and net OH-release stoichiometry显示文摘 | JAIN A RAVEN K P LOEPPERT R H | 1999 | Environmental Science & Technology1999，33，8： | 1 |
| 12 | A Markov random field model for classification of multisource satellite imagery显示文摘 | Solberg A H S Taxt T Jain A K | 1996 | IEEE Transactions on Geoscience and Remote Sensing1996，34，1： | 1 |
| 13 | Au nanoparticles target cancer显示文摘 | Jain P K El - Sayed I H and El - Sayed M A | 2007 | Nano Today2007，2，1： | 1 |
| 14 | Intermetallic compounds formed in In-3Ag solder BGA packages with ENIG and InAg surface finishes 显示文摘 | Chuang T H Jain C C | 2009 | JMEPEG2009，18，： | 1 |
| 15 | Calculated ab- sorption and scattering properties of gold nanoparticles of different size, shape, and composition : Applications in biological imaging and biomedicine 显示文摘 | Jain P K Lee K S E1-Sayed I H | 2006 | J Phys Chem B2006，110，14： | 1 |
| 16 | Laparoscopic partial splenectomy for splenic epidermoid cyst显示文摘 | Jain P Parelkar S Shah H | | 0，，06： | 1 |
| 17 | Arsenite and arsenate adsorption on ferrihydrite:kinetics,equilibrium and adsorption envelopes显示文摘 | Raven K P Jain A Loeppert R H | 1998 | Environmental Science and Technology1998，32，3： | 1 |
| 18 | The Effect of photo-oxidation on photobleaching of GeSe2 and Ge2Se3 films 显示文摘 | YAN Q JAIN H REN J | 2011 | J Phys Chem C2011，115，21： | 1 |
| 19 | Pelvic Fixation in adult and pediatric spine surgery:historical perspective,indications,and techniques:AAOS exhibit selection显示文摘 | Jain A Hassanzadeh H Strike SA | 2015 | J Bone Joint Surg Am2015，97，18： | 1 |
| 20 | A spectral approach to shape- based retrieval of articulated 3D models显示文摘 | JAIN V ZHANG H | 2007 | Computer Aided Design2007，39，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员