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| 1 | Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis显示文摘AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy.METHODS We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were used.RESULTS A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were reported.CONCLUSION In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course. | Animesh Jain Evan J Lipson William H Sharfman Steven R Brant Mark G Lazarev | 2017 | World Journal of Gastroenterology2017，23，11： | 8 |
| 2 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 3 | Response of blood pressure after percutaneous transluminal renal artery angioplasty and stenting显示文摘AIM: To evaluate the short and intermediate term out-come of percutaneous transluminal renal artery angioplasty (PTRA) and stenting particularly on blood pressure (BP) control and renal function and to evaluate predictors of poor BP response after successful PTRA and stenting. METHODS: We conducted a prospective analysis of all patients who underwent PTRA and stenting in our institute between August 2010 to September 2012. A total number of 86 patients were underwent PTRA and renal stenting. Selective angiography was done to confirm at least 70% angiographic stenosis. The predilatation done except few cases with critical stenosis, direct stenting was done in the rest of cases. All patients received aspirin 325 mg orally, and clopidogrel 300 mg orally within 24 h before the procedure. Heparin was used as the procedural anticoagulant agent. Optimal results with TIMI-Ⅲ flow obtained in all cases. Following stent placement, aspirin 150 mg orally once daily was continued for a minimum of 12 mo and clopidogrel 75 mg orally once daily for at least 4 wk. The clinical, radiological, electrocardiography, echocardiography and treatment data of all patients were recorded. The BP measurement, serum creatinine and glomerular filtration rate (GFR) were recorded before the procedure and 1 and 6 mo after PTRA. RESULTS: A total of 86 patients were included in the study. The mean age of study population was 55.87±11.85 years old and 67 (77.9%) of patients were male. There was a significant reduction in both systolic and diastolic BP at 1 mo after the procedure: 170.15±20.10 mmHg vs 146.60±17.32 mmHg and 98.38±10.55 mmHg vs 89.88±9.22 mmHg respectively (P=0.0000). The reduction in BP was constant throughout the follow-up period and was evident 6 mo after the procedure: 144.23±18.19 and 88.26±9.79 mmHg respectively (P=0.0000). However, no improvement in renal function was observed at any time during the follow-up period. After multivariate analysis, we found male sex, low GFR (<60 mL/min) and higher baseline mean BP as a poor predictors of successful outcome on BP response after PTRA and stenting. CONCLUSION: The PTRA and stenting can be considered as an effective therapeutic intervention for improving BP control with minimal effect on renal function. The male sex, higher baseline BP and low GFR are associated with poor BP response after successful PTRA and stenting. | Jayesh S Prajapati Sharad R Jain Hasit Joshi Shaurin Shah Kamal Sharma Sibasis Sahoo Kapil Virparia Ashok Thakkar | 2013 | World Journal of Cardiology2013，5，7： | 3 |
| 4 | Automatic road identification and labeling in Landsat 4 TM images显示文摘 | Ton J Jain A K Enslin W R | 1989 | Photogrammetric Engineering & Remote Sensing1989，43，： | 2 |
| 5 | Production model based digital video segmentation显示文摘 | HAMPAPUR A JAIN R C WEYMOUTH T | 1995 | international Journal of Multimedia Tools and Applications1995，1，1： | 1 |
| 6 | Hypersonic pressure,skin-friction and heat transfer distributions on space vehicles:three-dimensional bodies显示文摘 | Jain A C Hayes J R | 2004 | AIAA Journal2004，42，10： | 1 |
| 7 | Polycyclic aromatic hydrocarbons: environmental pollution and bioremediation 显示文摘 | SAMANTA S K SINGH O V JAIN R K | 2002 | Trends Biotechnol2002，20，6： | 1 |
| 8 | Segmentation through variable-order surface fitting显示文摘 | Besl P J Jain R C | 1988 | IEEE Transactions on Pattern Analysis and Machine Intelligence1988，10，2： | 1 |
| 9 | Decision making in the presence of fuzzy variables 显示文摘 | R JAIN | 1976 | IEEE TransSyst Man Cybern1976，，6： | 1 |
| 10 | On pre-straining and the evolution of material anisotropy in sheet metals显示文摘 | WU P D MACEWEN S R LLOYD D J JAIN M TUGCU P NEALE K W | 2005 | Int J Plasticity2005，21，： | 1 |
| 11 | Time and pH Dependent Colon Specific, Pulsatile Delivery of Theophylline for Nocturnal Asthma显示文摘 | Mastiholimath V S Dandagi P M Samata Jain S Gadad A P Kulkarni A R | 2007 | International Journal of Pharmaceutics2007，328，： | 1 |
| 12 | an XPS study of the effect of ZDDP on the AW/EP characteristics of molybdenum based additives 显示文摘 | Unnikrishnan R Jain M C Additive-additive interaction: Harinarayan A K | 2002 | Wear2002，252，3： | 1 |
| 13 | Muhidrug resistant acinetobacter in fections: an emerg ng challenge to clinicians显示文摘 | Jain R Danziger L H | 2004 | Ann Pharm acother2004，38，9： | 1 |
| 14 | On-line fingerprint verification 显示文摘 | Jain A K Hong L Bolle R | 1997 | IEEE Transactions on Pattern Analysis and Machine Intelligence1997，19，4： | 1 |
| 15 | Evaluation of p53 and bcl-2 expression as prognostic markers in invasive cervical carcinoma stage Ⅱ b/Ⅲ patients treated by radiotherapy 显示文摘 | Jain D Srinivasan R Patel FD | 2003 | Gynecol Oncol2003，88，1： | 1 |
| 16 | Using dynamic programming for solving variational problems in version显示文摘 | AMINI A A WEYMOUTH T E JAIN R C | 1990 | Pattern Analysis and Machine Intelligence1990，12，9： | 1 |
| 17 | Modeling of material removal and surface roughness in abrasive flow machining process显示文摘 | Jain R K Jain V K Dixit P M | 1999 | International Journal of Machine Tools & Manufacture1999，39，19： | 1 |
| 18 | Characterization and identification of forming features for 3-D sheet metal components显示文摘 | Jagirdar R Jain V K Batra J L | 2001 | International Journal of Machine Tools and Manufacture2001，41，9： | 1 |
| 19 | General weighted fairness and its support in explicit rate switch algorithms显示文摘 | VANDALORE B FAHMY S JAIN R | 2000 | Computer Communications2000，23，2： | 1 |
| 20 | Randomized clinical trial investigating the use of drains and fibrin sealant following surgery for breast cancer显示文摘 | Jain PK Sowdi R Anderson AD | 2004 | Br J Surg2004，91，1： | 1 |
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