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| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | Linking FDI Motivation and Host Econ- omy Productivity Effects: Conceptual and Empirical Analysis 显示文摘 | Nige James H Love | 2007 | Journal of International Business Studies2007，，3： | 1 |
| 3 | Foreign Direct Investment, Technology Sourcing and Reverse Spillovers 显示文摘 | Driffield Nigel and Love James H | 2003 | The Manchester School2003，71，6： | 1 |
| 4 | Location and net-work effects on innovation success: evidence for UK, Ger-man and Irish manufacturing plants 显示文摘 | JAMES H LOVE STEPHEN ROPER | 2001 | Research Policy2001，，30： | 1 |
| 5 | Productivityand labour demand effects of inward and outward foreign directinvestment on UK industry显示文摘 | Nigel Driffield James H Love Karl Taylor | 2009 | The Manchester School2009，77，： | 1 |
| 6 | Location and network effects on innovation success:evidence for UK,German and Irish manufacturing plants显示文摘 | James H Love Stephen Roper | 2001 | Research Policy2001，30，： | 1 |
| 7 | Service innovation, embeddedness and business performance: Evi- dence from Northern Ireland 显示文摘 | James H Love S R Hewitt-Dundas N | 2010 | Regional Studies2010，44，8： | 1 |
| 8 | Foreign Direct Investment, Technology Sourcing and Reverse Spillovers 显示文摘 | Driffield Nigel and Love James H | 2003 | The Manchester School2003，71，6： | 1 |
| 9 | Who Gains from Whom? Spillovers, Competition and Technology Sourcing in the Foreign-owned Sector of UK Manufacturing 显示文摘 | Driffield Nigel and Love James H | 2005 | Scottish Journal of Policial Economy2005，52，5： | 1 |
| 10 | Linking FDI Motivation and Host E- conomy Productivity Effects: Conceptual and Empirical Analysis 显示文摘 | Nigel Driffield James H Love | 2007 | Journal of International Business Studies2007，，3： | 1 |
| 11 | Foreign Direct Ivestment, Technol- ogy Sourcing and Reverse Spillovers 显示文摘 | Driffield Nigel Love James H | 2003 | The Manchester School2003，71，6： | 1 |
| 12 | Corporate structure, ownership and the likelihood of innovation 显示文摘 | James H Love Brian Ashcroft Stewart Dunlop | 1996 | Applied Economics1996，28，6： | 1 |
| 13 | Outsourcing in the innovation process:Locational and strategic determinants显示文摘 | JAMES H LOVE | 2001 | Papers in Regional Science2001，2001，： | 1 |
| 14 | Location and network effects on innovation success:evidence for UK, German and Irish manufactur- ing plants显示文摘 | James H Love Stephen Roper | 2001 | Research Policy2001，30，4： | 1 |
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