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| 1 | Effects of selenomethionine on acute toxicities from concurrent chemoradiation for inoperable stage Ⅲ nonsmall cell lung cancer显示文摘AIM: To prospectively determine the safety and tolerability of oral L-selenomethionine(SLM) with concurrent chemoradiation(CCRT) for Stage Ⅲ non-small cell lung cancer(NSCLC) and estimate if the incidence and/or severity of adverse events could be reduced by its use.METHODS: Sixteen patients with stage Ⅲ NSCLC were accrued to this single arm, phase Ⅱ study. CCRT consisted of radiation given at 2 Gy per fraction for 30-33 fractions, 5 d per week with concurrent weekly Ⅳ paclitaxel 50 mg/m2 followed by carboplatin dosed at an area under the time-concentration curve of 2. SLM was dosed in a loading phase at 4800 μg twice daily for one week prior to CCRT followed by once daily dosing during treatment. RESULTS: No selenium-related toxicity was observed. Analysis revealed grade 3 or higher esophagitis in 3 of 16 patients(19%), pneumonitis in 0, leukopenia in 2(12.5%), and anemia in 1(6%); the latter two were significantly reduced when compared to the protocolstated expected rate of 35%(P = 0.045 for leukopenia, and P < 0.01 for anemia). Median overall survival was 14.9 mo and median failure-free survival was 9 mo(95%CI: 3.3-21.5).CONCLUSION: There may be some protective benefit of selenium in the setting of CCRT for inoperable NSCLC. The data suggests decreased rates of myelosuppression when compared to similarly-treated historical and contemporary controls. Further evaluation of selenium in this setting may be warranted. | Michael Mix Nithya Ramnath Jorge Gomez Charles de Groot Saju Rajan Shiva Dibaj Wei Tan Youcef Rustum Michael B Jameson Anurag K Singh | 2015 | World Journal of Clinical Oncology2015，6，5： | 4 |
| 2 | The antigenic index: a novel algo- rithm for predicting antigenic determinants显示文摘 | Jameson B A Wolf H | 1988 | Cornput Ap- plBiosci1988，4，1： | 1 |
| 3 | The antigenic index:a novel algorithmfor predicting antigenic determinants显示文摘 | Jameson B A Wolf H | 1988 | Comput Appl Biosci1988，4，1： | 1 |
| 4 | The antigenic index: a novel algorithm for predicing antigenic determinants显示文摘 | JAMESON B A WOLF H | 1988 | Comput Appl Biosci1988，4，1： | 1 |
| 5 | Hemodynamics and emergence profile of remifentanil versus fentanyl prospectively compared in a large population of surgical patients显示文摘 | TWERSKY RS JAMESON B WARNER DS | 2001 | J Clin Anesth2001，13，6： | 1 |
| 6 | Human follicle- stimulating hormone beta -subunit gene encodes multiple messenger ribonucleic acids显示文摘 | Jameson J L Becker C B Lindell C M | 1958 | Mol Endocrinol1958，2，9： | 1 |
| 7 | Synthesis,complexation and cyclisation reactions of a new acyclic diamide:Observation of intramolecular ligand exchange in a structurally characterised nickel(Ⅱ)complex显示文摘 | BROOKER S DUNBAR G S JAMESON G B | 1999 | Polyhedron1999，18，5： | 1 |
| 8 | The antigenic index,a novel algorithm for predicting antigenic determinants显示文摘 | JAMESON B A WOL F H | 1988 | Biotechnol Appl Biochem1988，4，1： | 1 |
| 9 | The antigenic index: a novel algorithm for predicting antigenic determinants显示文摘 | JAMESON B WOLF H | 1988 | Bioinformatics1988，4，1： | 1 |
| 10 | Rheology of firefighting foams显示文摘 | Gardiner B S Dlugogorski B Z Jameson G J | 1998 | Fire Safety J1998，31，1： | 1 |
| 11 | Localization of the high molecular weight kininogen binding site in the heavy chain of human factor XI to amino acids phenylala- nine 56 through serine 86 显示文摘 | BAGLIA F A JAMESON B A WALSH P N | 1990 | J Biol Cbem1990，265，7： | 1 |
| 12 | Pregnancy increases mobilization of lead from maternal skeleton 显示文摘 | GULSON B L JAMESON C W MAHAFFEY K R | 1997 | J Lab Clin Med1997，130，1： | 1 |
| 13 | Electrophysiologie Monitoring in Neurosurgery 显示文摘 | Leslie C Jameson Daniel J Jasnik Tod B Sloan | 2007 | Anesthesiology Clin2007，25，： | 1 |
| 14 | The antigenic index: a novel algorithm for predicting antigenic determinants显示文摘 | Jameson B A Wolf H | 1988 | Cabios1988，4，1： | 1 |
| 15 | Identification and chemical synthesis of a substrate-binding site for factor IX on coagulation factor XIa 显示文摘 | BAGLIA F A JAMESON B A WALSH P N | 1991 | J Biol Chem1991，266，24： | 1 |
| 16 | The antigenic index:A novel algorithm for prediction antigenic determinants 显示文摘 | JAMESON B A WOLF H | 1988 | Comput Appl Biosci1988，，4： | 1 |
| 17 | Stereotactic injec- tion of adenoviral vectors that target gene expression to specific pituitary cell types: implications for gene therapy 显示文摘 | Lee EJ Thimmapaya B Jameson JL | 2000 | Neurosurgery2000，46，： | 1 |
| 18 | Rheo-logy of fire-fighting foams显示文摘 | Gardiner B S Dlugogorski B Z Jameson G J | | 0，，01： | 1 |
| 19 | Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor 显示文摘 | GEHM B D CHIEN P Y JAMESON J L | 1997 | Proc Natl Acad Sci1997，94，14： | 1 |
| 20 | Domain 5 of high molecular weight kininogen(kininostation) down regulates endothelial cell prolifer at ion and migration and inhibits angiogenesis显示文摘 | Colman R W Jameson B A Lin Y | 2000 | Blood2000，95，2： | 1 |
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