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| 1 | Broadband achromatic metalens in terahertz regime显示文摘Achromatic focusing is essential for broadband operation, which has recently been realised from visible to infrared wavelengths using a metasurface. Similarly, multi-terahertz functional devices can be encoded in a desired metasurface phase profile. However, metalenses suffer from larger chromatic aberrations because of the intrinsic dispersion of each unit element. Here, we propose an achromatic metalens with C-shaped unit elements working from 0.3 to 0.8 THz with a bandwidth of approximately 91% over the centre frequency. The designed metalens possesses a high working efficiency of more than 68% at the peak and a relatively high numerical aperture of 0.385. We further demonstrate the robustness of our Cshaped metalens, considering lateral shape deformations and deviations in the etching depth. Our metalens design opens an avenue for future applications of terahertz meta-devices in spectroscopy, time-offlight tomography and hyperspectral imaging systems. | Qingqing Cheng Meilin Ma Dong Yu Zhixiong Shen Jingya Xie Juncheng Wang Nianxi Xu Hanming Guo Wei Hu Shuming Wang Tao Li Songlin Zhuang | 2019 | Science Bulletin2019，64，20： | 16 |
| 2 | Lipid analysis of three special nervonic acid resources in China显示文摘Nervonic acid plays an important role in nutrition and function of the human body.Malania oleifera,Acer truncatum and Xanthoceras sorbifolium are China’s unique woody plant rich in nervonic acid in seed oil.This study aims to investigate the lipid composition of these 3 special resources.Their fatty acids were detected by gas chromatography coupled with flame detector(GC-FID).Triglycerides(TAGs)and phospholipids(PLs)were detected by shotgun-mass spectrometry(shotgun-MS).Results showed that M.oleifera oil presented the highest level of nervonic acid(46.20±0.22%)among the 3 oils.Seeds oil of A.truncatum and X.sorbifolium had 3.53±0.20%and 1.83±0.21%nervonic acid respectively.53 species of TAGs and 15 species of PLs were identified in M.oleifera oil,with PLs content of 499.94±22.34μg/g.In A.truncatum oil,PL and TAG species were twice more than those in M.oleifera oil,and its’content of PLs was 76.27±3.21μg/g.In X.sorbifolium oil,75 TAGs and 34 PLs were detected,with the lowest PLs at 23.84±0.17μg/g.The results demonstrated that these 3 vegetable oils have great potential to become nervonic acid supplements for human health. | Xinghao Tu Jingya Wan Ya Xie Fang Wei Siewyoung Quek Xin Lv Liqing Du Hong Chen | 2020 | Oil Crop Science2020，5，4： | 7 |
| 3 | Diterpenoid UDP-Glycosyltransferases from Chinese Sweet Tea and Ashitaba Complete the Biosynthesis of Rubusoside显示文摘 | Yuwei Sun Zhuo Chen Jianxu Li Jianhua Li Huajun LV Jingya Yang Weiwei Li Dingan Xie Zhiqiang Xiong Peng Zhang Yong Wang | 2018 | Molecular Plant2018，11，10： | 7 |
| 4 | Metasurfaces for manipulating terahertz waves显示文摘Terahertz(THz)science and technology have attracted significant attention based on their unique applications in non-destructive imaging,communications,spectroscopic detection,and sensing.However,traditional THz devices must be sufficiently thick to realise the desired wave-manipulating functions,which has hindered the development of THz integrated systems and applications.Metasurfaces,which are two-dimensional metamaterials consisting of predesigned meta-atoms,can accurately tailor the amplitudes,phases,and polarisations of electromagnetic waves at subwavelength resolutions,meaning they can provide a flexible platform for designing ultra-compact and high-performance THz components.This review focuses on recent advancements in metasurfaces for the wavefront manipulation of THz waves,including the planar metalens,holograms,arbitrary polarisation control,special beam generation,and active metasurface devices.Such ultra-compact devices with unique functionality make metasurface devices very attractive for applications such as imaging,encryption,information modulation,and THz communications.This progress report aims to highlight some novel approaches for designing ultra-compact THz devices and broaden the applications of metasurfaces in THz science. | Xiaofei Zang Bingshuang Yao Lin Chen Jingya Xie Xuguang Guo Alexei VBalakin Alexander P.Shkurinov Songlin Zhuang | 2021 | Light(Advanced Manufacturing)2021，2，2： | 4 |
| 5 | Dual-layered metasurfaces for asymmetric focusing显示文摘Asymmetric transmission,defined as the difference between the forward and backward transmission,enables a plethora of applications for on-chip integration and telecommunications.However,the traditional method for asymmetric transmission is to control the propagation direction of the waves,hindering further applications.Metasurfaces,a kind of two-dimensional metamaterials,have shown an unprecedented ability to manipulate the propagation direction,phase,and polarization of electromagnetic waves.Here we propose and experimentally demonstrate a metasurface-based directional device consisting of a geometric metasurface with spatially rotated microrods and metallic gratings,which can simultaneously control the phase,polarization,and propagation direction of waves,resulting in asymmetric focusing in the terahertz region.These dual-layered metasurfaces for asymmetric focusing can work in a wide bandwidth ranging from 0.6 to 1.1 THz.The flexible and robust approach for designing broadband asymmetric focusing may open a new avenue for compact devices with potential applications in encryption,information processing,and communication. | BINGSHUANG YAO XIAOFEI ZANG ZHEN L LIN CHEN JINGYA XIE YIMING ZHU SONGLIN ZHUANG | 2020 | Photonics Research2020，8，6： | 2 |
| 6 | All-optical wavelength converter using a microdisk resonator integrated with p-n junctions显示文摘We explore all-optical wavelength conversion in a microdisk resonator integrated with interleaved p-n junctions.Numerical simulation based on temporal coupled mode theory is performed to study the free-carrier dynamics inside the cavity.It reveals that the detuning of pump and probe frequencies and the carrier lifetime have a significant effect on the device performance.Experimental result confirms that the conversion speed can be considerably improved by applying a reverse bias on the p-n junctions.Wavelength conversion at 10 Gb/s data rate is achieved with a pump power of 5.41 dBm and a bias voltage of-6 V. | Linjie Zhou Jingya Xie Jianping Chen | 2014 | Chinese Science Bulletin2014，59，22： | 2 |
| 7 | Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia显示文摘Hepatic cholesterol accumulation is an important contributor to hypercholesterolemia,which results in atherosclerosis and cardiovascular disease(CVD).ATP-citrate lyase(ACLY)is a key lipogenic enzyme that converts cytosolic citrate derived from tricarboxylic acid cycle(TCA cycle)to acetyl-CoA in the cytoplasm.Therefore,ACLY represents a link between mitochondria oxidative phosphorylation and cytosolic de novo lipogenesis.In this study,we developed the small molecule 326E with an enedioic acid structural moiety as a novel ACLY inhibitor,and its CoA-conjugated form 326E-CoA inhibited ACLY activity with an IC_(50)=5.31±1.2μmol/L in vitro.326E treatment reduced de novo lipogenesis,and increased cholesterol efflux in vitro and in vivo.326E was rapidly absorbed after oral administration,exhibited a higher blood exposure than that of the approved ACLY inhibitor bempedoic acid(BA)used for hypercholesterolemia.Chronic 326E treatment in hamsters and rhesus monkeys resulted in remarkable improvement of hyperlipidemia.Once daily oral administration of 326E for 24 weeks prevented the occurrence of atherosclerosis in ApoE^(-/-)mice to a greater extent than that of BA treatment.Taken together,our data suggest that inhibition of ACLY by 326E represents a promising strategy for the treatment of hypercholesterolemia. | Zhifu Xie Mei Zhang Qian Song Long Cheng Xinwen Zhang Gaolei Song Xinyu Sun Min Gu Chendong Zhou Yangming Zhang Kexin Zhu Jianpeng Yin Xiaoyan Chen Jingya Li Fajun Nan | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 8 | Screening of microRNAs associated with Alzheimer’s disease using oxidative stress cell model and different strains of senescence accelerated mice显示文摘 | Rui Zhang Qingfu Zhang Jingya Niu Kang Lu Bing Xie Dongsheng Cui Shunjiang Xu | 2013 | Journal of the Neurological Sciences2013，，： | 1 |
| 9 | Spin-decoupled metalens with intensity-tunable multiple focal points显示文摘The control of spin electromagnetic(EM)waves is of great significance in optical communications.Although geometric metasurfaces have shown unprecedented capability to manipulate the wavefronts of spin EM waves,it is still challenging to independently manipulate each spin state and intensity distribution,which inevitably degrades metasurface-based devices for further applications.Here we propose and experimentally demonstrate an approach to designing spin-decoupled metalenses based on pure geometric phase,i.e.,geometric metasurfaces with predesigned phase modulation possessing functionalities of both convex lenses and concave lenses.Under the illumination of left-/right-handed circularly polarized(LCP or RCP)terahertz(THz)waves,these metalenses can generate transversely/longitudinally distributed RCP/LCP multiple focal points.Since the helicity-dependent multiple focal points are locked to the polarization state of incident THz waves,the relative intensity between two orthogonal components can be controlled with different weights of LCP and RCP THz waves,leading to the intensity-tunable functionality.This robust approach for simultaneously manipulating orthogonal spin states and energy distributions of spin EM waves will open a new avenue for designing multifunctional devices and integrated communication systems. | BINGSHUANG YAO XIAOFEI ZANG YANG ZHU DAHAI YU JINGYA XIE LIN CHEN SEN HAN YIMING ZHU SONGLIN ZHUANG | 2021 | Photonics Research2021，9，6： | 1 |
| 10 | An integrative profiling of metabolome and transcriptome in the plasma and skeletal muscle following an exercise intervention in diet-induced obese mice显示文摘Exercise intervention at the early stage of type 2 diabetes mellitus(T2DM)can aid in the maintenance of blood glucose homeostasis and prevent the development of macrovascular and microvascular complications.However,the exercise-regulated pathways that prevent the development of T2DM remain largely unclear.In this study,two forms of exercise intervention,treadmill training and voluntary wheel running,were conducted for high-fat diet(HFD)-induced obese mice.We observed that both forms of exercise intervention alleviated HFD-induced insulin resistance and glucose intolerance.Skeletal muscle is recognized as the primary site for postprandial glucose uptake and for responsive alteration beyond exercise training.Metabolomic profiling of the plasma and skeletal muscle in Chow,HFD,and HFD-exercise groups revealed robust alterations in metabolic pathways by exercise intervention in both cases.Overlapping analysis identified nine metabolites,including beta-alanine,leucine,valine,and tryptophan,which were reversed by exercise treatment in both the plasma and skeletal muscle.Transcriptomic analysis of gene expression profiles in the skeletal muscle revealed several key pathways involved in the beneficial effects of exercise on metabolic homeostasis.In addition,integrative transcriptomic and metabolomic analyses uncovered strong correlations between the concentrations of bioactive metabolites and the expression levels of genes involved in energy metabolism,insulin sensitivity,and immune response in the skeletal muscle.This work established two models of exercise intervention in obese mice and provided mechanistic insights into the beneficial effects of exercise intervention on systemic energy homeostasis. | Shuang Han Qingqian Wu Mengying Wang Miqi Yang Chen Sun Jiaqi Liang Xiaozhen Guo Zheyu Zhang Jingya Xu Xinyuan Qiu Cen Xie Siyu Chen Yue Gao Zhuo-Xian Meng | 2023 | Journal of Molecular Cell Biology2023，15，3： | 0 |
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