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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 3 | Expression of c-kit receptor in human cholangiocarcinoma and in vivo treatment with imatinib mesilate in chimeric mice显示文摘瞄准:与额外的肝的 cholangiocarcinoma (CC ) 从病人在胆道癌症房间线和组织学的节调查 c 工具包表示并且与 imatinib mesilate 评估在试管内和在试管内治疗的功效。方法:在从有额外的肝的 CC 的 19 个病人的人的胆道癌症房间线 Mz-ChA-2 和 EGI-1 和组织学的节的 c 工具包的蛋白质表示被免疫弄污,免疫细胞化学,和免疫组织化学估计。胆道癌症房间线 Mz-ChA-2 和 EGI-1 上的 imatinib mesilate 的 anti-proliferative 效果是由自动化房间数的学习在试管内。另外,免疫缺乏的 NMRI 老鼠(Taconic ) 皮下地与 5x10 (6 ) 被注射房间线 MzChA-2 和 EGI-1 的房间。在到达了 200 mm3 的瘤体积以后,每日的治疗在 50 mg/kg 或生理盐水(NS ) 的剂量以 imatinib mesilate intraperitoneally 被开始。肿瘤体积与游标 caliper 被计算。在 14 d 以后,老鼠被牺牲,肿瘤和决定的肿瘤质量切除了。结果:Immunoblotting 在 EGI-1 房间在 Mz-ChA-2 和缺席揭示了 c 工具包的存在。有 c 工具包抗体的 Immunocytochemistry 在 EGI-1 房间在 Mz-ChA-2 房间和 c 工具包的缺席显示了 cytoplasmatic 和受体蛋白质的膜的本地化。c 工具包在 19 中的 7 个被表示(37%) 额外的肝的人的 CC 织物取样, 2 出现了一中等并且染色的 5 一相当弱的免疫。在 5 micromol/L 的低集中的 Imatinib mesilate 在 c 工具包引起了重要生长抑制积极房间线 Mz-ChA-2 (31%) ,然而并非在 c 工具包 negative,房间衬里 EGI-1 (0%)(P<0.05 ) 。在 10 micromol/L 的中间的集中的 Imatinib mesilate 禁止了两根细胞线(51% 对 57%) 的细胞的生长。在 20 micromol/L 的更高的集中的 Imatinib mesilate 似乎在两根房间线上有一般有毒的效果。IC50 价值分别地是 9.7 micromol/L 和 11 micromol/L。在有 imatinib mesilate 的在试管内处理的 14 d 以后,使用妄想的老鼠模型,积极 Mz-ChA-2 肿瘤有的 c 工具包显著地减少的体积和团作为与 NS 处理(P<0.05 ) 相比。与那相对照,忍受 c 工具包 negative EGI-1 肿瘤的鼠标的处理没作为与 NS 处理相比导致肿瘤体积和质量的任何变化。结论:c 工具包表示是可检测的在一对在胆道癌症的低蛋白质水平中等。Imatinib mesilate 在肿瘤生长在试管内和 c 工具包表示诚实的在试管内依赖者上施加显著效果。 | Thomas Kamenz Karel Caca Thilo Blüthner Andrea Tannapfel Joachim Mssner Marcus Wiedmann | 2006 | World Journal of Gastroenterology2006，12，10： | 7 |
| 4 | DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection显示文摘 | Oertli Mathias Sundquist Malin Hitzler Iris Engler Daniela B Arnold Isabelle C Reuter Sebastian Maxeiner Joachim Hansson Malin Taube Christian Quiding-J?rbrink Marianne Müller Anne | 2012 | EN2012，，3： | 5 |
| 5 | BP神经网络在使用红外热像仪技术预测冬小麦产量中的应用(英文)显示文摘通过使用红外热像仪技术获得冬小麦冠层不同温度值,计算得到冬小麦主要需水阶段水分胁迫指标ICWSI(infrared crop water stress index)。并根据此数据,使用一次灌溉周期中3个时段不同的ICWSI的平均值作为输入因子,相应实测冬小麦产量作为输出因子,建立了BP神经网络模型对冬小麦的产量进行预测,本文采用三层BP神经网络,其拓扑结构为3-5-1,数据归一化处理后收敛性能增强。预测结果显示,平均相对误差最大只有3.42%;为了证实这一方法的优越性,同时建立了基于ICWSI和冬小麦产量关系的非线性函数的预测模型,预测结果与实际产量值进行比较,平均相对误差最大达到了18.87%。两种预测方法得到的不同预测结果表明,将红外热像仪技术与BP神经网络预测方法相结合,可以成功用来预测冬小麦产量,比使用非线性函数预测的效果更好,精度更高,可靠性更强,可以用于实际生产需要。 | 胡振方 张录达 王珏璇 Shamaila Z 曾爱君 宋坚利 刘亚佳 Wolfram S Joachim M 何雄奎 | 2013 | 光谱学与光谱分析2013，33，6： | 5 |
| 6 | Treatment of biliary tract cancer with NVP-AEW541:Mechanisms of action and resistance显示文摘AIM:To investigate in vitro treatment with NVPAEW541,a small molecule inhibitor of insulin-like growth factor-1 receptor(IGF-1R),in biliary tract cancer (BTC),since this disease is associated with a poor prognosis due to wide resistance to chemotherapeutic agents and radiotherapy.METHODS:Cell growth inhibition by NVP-AEW541 was studied in vitro in 7 human BTC cell lines by automated cell counting.In addition,the anti-tumoral mechanism of NVP-AEW541 was studied by Western blotting,cell cycle analysis and reverse transcription-polymerase chain reaction(RT-PCR).Anti-tumoral drug effect in combination with gemcitabine,5-fluorouracil(5-FU)and Polo-like kinase 1 inhibitor BI2536 was also studied. RESULTS:In vitro treatment with NVP-AEW541 suppressed growth in all human BTC cell lines,however response was lower in gallbladder cancer.Treatment withNVP-AEW541 was associated with dephosphorylation of IGF-1R and AKT.In contrast,phosphorylation of p42/p44 and Stat3 and expression of Bcl-xL were inconsistently downregulated.In addition,treated cells showed cell cycle arrest at the G1/S-checkpoint and an increase in sub-G1 peak.Moreover,IGF-1R and its ligands IGF-1 and IGF-2 were co-expressed in RT-PCR,suggesting an autocrine loop of tumor cell activation.Combined with gemcitabine,NVP-AEW541 exerted synergistic effects, particularly at low concentrations,while effects of combination with 5-FU or BI 2536 were only additive. CONCLUSION:Our findings suggest that NVP-AEW541 is active against BTC in vitro and potentiates the efficacy of gemcitabine. | Samuel Wolf Jana Lorenz Joachim Mssner Marcus Wiedmann | 2010 | World Journal of Gastroenterology2010，16，2： | 5 |
| 7 | Determination of surface color of‘all yellow’mango cultivars using computer vision显示文摘Image processing techniques are increasingly applied in sorting applications of agricultural products.This work has assessed the use of image processing for inspecting surface color of two Thai mango cultivars.A computer vision system(CVS)was developed and experiments were conducted to monitor peel color change during the ripening process.Conversion of RGB to CIE-LAB values was done via image processing and prediction models were developed to estimate color parameters from CVS data.Performance evaluations showed insufficient prediction for L values(R2=0.42-0.58),but better results for A and B values(R2=0.90-0.95 and 0.80-0.82,respectively).Compared to the calculated color values hue angle and chroma,a yellowness index computed from intermediate XYZ values was found to be much more adept at accurately predicting peel color from CVS data.Correlations were strong for both cultivars(R2=0.93 for‘Nam Dokmai’and R2=0.95 for‘Maha Chanok’).Results from classification analysis indicated satisfactory results for classifying fruits according to ripeness based on yellowness.Success rates of true positives in the categories unripe,ripe and overripe ranged 72%-92%for‘Nam Dokmai’and 98%-100%for‘Maha Chanok’.Therefore,it was shown that the CVS was capable of producing accurate color values for the two mango cultivars investigated.The findings of this study can be incorporated for development of a robust system for quality prediction and establishment of a CVS for automatic grading and sorting of mangos. | Marcus Nagle Kiatkamjon Intani Giuseppe Romano Busarakorn Mahayothee Vicha Sardsud Joachim Müller | 2016 | International Journal of Agricultural and Biological Engineering2016，9，1： | 5 |
| 8 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 9 | Acoustic radiation force impulse imaging (ARFI) for non-invasive detection of liver fibrosis: examination standards and evaluation of interlobe differences in healthy subjects and chronic liver disease显示文摘 | Thomas Karlas Cornelia Pfrepper Johannes Wiegand Christian Wittekind Marie Neuschulz Joachim M?ssner Thomas Berg Michael Tr?ltzsch Volker Keim | 2011 | Scandinavian Journal of Gastroenterology2011，，12： | 4 |
| 10 | Assessing crop water stress of winter wheat by thermography under different irrigation regimes in North China Plain显示文摘Thermal imaging can be used as an indicator of water stress due to the closure of stomatal aperture.In this paper,we analyzed the robustness and sensitivity of thermography of winter wheat in the North China Plain.The seasonal and diurnal variations of Crop Water Stress Index(CWSI)were evaluated.Five treatments were applied by means of irrigation,with plots receiving 100%of ETo(DI),50%(D50),16%(D16)and no irrigation(NI).A high correlation was found between stomatal conductance(gs)and CWSI,depending on the phenological stage of the crop with R2=0.44 at pre-heading stage and R2=0.77 at post-heading stage.In addition,a high correlation between yield and CWSI at different growth stages indicates that thermography can predict yield.Hourly measurements of canopy temperature were taken to study the effect of the time of day on image acquisition and it was found that midday was the most appropriate time.These results should assist in designing precision irrigation scheduling for setting the threshold values. | Shamaila Zia Du Wenyong Wolfram Spreer Klaus Spohrer He Xiongkui Joachim Müller | 2012 | International Journal of Agricultural and Biological Engineering2012，5，3： | 4 |
| 11 | Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis显示文摘AIM:To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy.METHODS: An open label multicenter study was carried out in 39 patients with active ulcerative colitis (CAI6-8) despite continuous use of steroids (a minimum total dose of 400 mg prednisone within the last 4 wk).Patients received a total of five aphereses using a granulocyte adsorptive technique (Adacolumn(R), Otsuka Pharmaceutical Europe, UK). Assessments at wk 6 and during follow-up until 4 mo comprised clinical (CAI) and endoscopic (EI) activity index, histology, quality of life(IBDQ), and laboratory tests.RESULTS: Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 (37.1%) patients achieved clinical remission and 10/35 (28.6%) patients had endoscopic remission (CAI<4, EI<4). Quality of life (IBDQ) increased significantly (24 points, P<0.01)at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia.CONCLUSION: In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent. | Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert L(o|¨)fberg | 2005 | World Journal of Gastroenterology2005，11，44： | 4 |
| 12 | Utilization of Thermal Infrared Image for Inversion of Winter Wheat Yield and Biomass显示文摘The present paper utilizes thermal infrared image for inversion of winter wheat yield and biomass with different technology of irrigation(drip irrigation,sprinkler irrigation,flood irrigation).It is the first time that thermal infrared image is used for predicting the winter wheat yield and biomass.The temperature of crop and background was measured by thermal infrared image.It is necessary to get the crop background separation index(CBSIL,CBSIH),which can be used for distinguishing the crop value from the image.CBSIL and CBSIH(the temperature when the leaves are wet adequately;the temperature when the stomata of leaf is closed completely) are the threshold values.The temperature of crop ranged from CBSIL to CBSIH.Then the ICWSI was calculated based on relevant theoretical method.The value of stomata leaf has strong negative correlation with ICWSI proving the reliable value of ICWSI.In order to construct the high accuracy simulation model,the samples were divided into two parts.One was used for constructing the simulation model,the other for checking the accuracy of the model.Such result of the model was concluded as:(1) As for the simulation model of soil moisture,the correlation coefficient(R2) is larger than 0.887 6,the average of relative error(Er) ranges from 13.33% to 16.88%;(2) As for the simulation model of winter wheat yield,drip irrigation(0.887 6,16.89%,-0.12),sprinkler irrigation(0.970 0,14.85%,-0.12),flood irrigation(0.969 0,18.87%,0.18),with the values of R2,Er and CRM listed in the parentheses followed by the individual term.(3) As for winter wheat biomass,drip irrigation(0.980 0,13.70%,0.13),sprinkler irrigation(0.95,13.15%,-0.14),flood irrigation(0.970 0,14.48%,-0.13),and the values in the parentheses are demonstrated the same as above.Both the CRM and Er are shown to be very low values,which points to the accuracy and reliability of the model investigated.The accuracy of model is high and reliable.The results indicated that thermal infrared image can be used potentially for inversion of winter wheat yield and biomass. | DU Wen-yong ZHANG Lu-da HU Zhen-fang Shamaila Z ZENG Ai-jun SONG Jian-li LIU Ya-jia Wolfram S Joachim M HE Xiong-kui | 2011 | 光谱学与光谱分析2011，31，6： | 3 |
| 13 | Non-invasive water status detection in grapevine(Vitis vinifera L.)by thermography显示文摘Grapevines are preferentially grown under mild to moderate water stress conditions to achieve the best compromise between wine quality and quantity.Water status detection for advanced irrigation scheduling is frequently done by predawn leaf water potential(ΨPD)or leaf stomata conductance(gL)measurements.However,these measurements are time and labor consuming.Therefore,the use of infrared thermography(IRT)opens up the possibility to study large population of leaves and to give an overview on the stomatal variation and their dynamics.In the present study IRT was used to identify water stress of potted grapevines.In order to define the sensitivity of IRT measurements to water stress,the IRT-based water status information were compared with simultaneously measuredΨPD and gL data.Correlations between IRT-based CWSI data on the one hand and gL andΨPD on the other showed the potential of IRT for water stress detection.However,the CWSI calculation procedure is laborious and the sensitivity of CWSI for water stress detection still needs to be improved.Therefore,further improvements are necessary in order to apply remote IRT-based systems for irrigation scheduling in the field. | Shamaila Zia Klaus Spohrer Nikolaus Merkt Du Wenyong Xiongkui He Joachim Müller | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 3 |
| 14 | Monitoring physiological responses to water stress in two maize varieties by infrared thermography显示文摘Water stress is one of the main causes of yield reductions in crops,especially in arid and semi-arid regions where the water supply is limited.Plant water status is frequently assessed by pre-dawn leaf water potential(ΨPD)or leaf stomata conductance(gL)measurements,in support of advanced irrigation scheduling.However,both methods are time and labour consuming.A non-invasive approach to water status detection is the use of infrared thermography(IRT).This experiment was conducted in a greenhouse on two potted maize varieties under irrigated and non-irrigated conditions,and the measurements began when the crop had reached its twelve leaf stage.In order to establish the IRT measurements for detecting the water status of maize,an IRT-based crop water stress index(CWSI)was calculated and compared with simultaneously measuredΨPD and gL data.Good correlations were found between CWSI and gL data(r2=0.71&0.81),as well between CWSI andΨPD data(r2=0.53&0.81).These results highlight the appropriateness of infrared thermal imagery to detect and differentiate between the crop water statuses of different genotypes. | Shamaila Zia Klaus Sophrer Du Wenyong Wolfram Spreer Giuseppe Romano He Xiongkui Joachim Müller | 2011 | International Journal of Agricultural and Biological Engineering2011，4，3： | 3 |
| 15 | Non-invasive evaluation of hepatic manifestation in Wilson disease with transient elastography, ARFI, and different fibrosis scores显示文摘 | Thomas Karlas Maria Hempel Michael Tr?ltzsch Dominik Huster Peter Günther Hannelore Tenckhoff Joachim M?ssner Thomas Berg Volker Keim Johannes Wiegand | 2012 | Scandinavian Journal of Gastroenterology2012，，11： | 2 |
| 16 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 2 |
| 17 | Allogeneic partially HLA-matched dendritic cells pulsed with autologous tumor cell lysate as a vaccine in metastatic renal cell cancer显示文摘 | Anne Fl?rcken Joachim Kopp Antje van Lessen Kamran Movassaghi Anna Takvorian Korinna J?hrens Markus M?bs Constanze Sch?nemann Birgit Sawitzki Karl Egerer Bernd D?rken Antonio Pezzutto J?rg Westermann | 2013 | Human Vaccines & Immunotherapeutics2013，，： | 2 |
| 18 | Influence of colour changes and moisture content during banana drying on laser backscattering显示文摘Pre-drying treatments are frequently employed to preserve fruit quality.The objective of this research was to monitor colour changes of banana during drying by laser backscattering and to determine the influence of the fruit discolouration on the light distribution into banana tissue.Moreover,to examine the influence of drying on the laser backscatter,the relationship between moisture content and relative laser area of banana slices was analyzed with different degrees of colour degradation.The experiments were conducted at drying air temperature of 63℃with various pre-treatments like chilling,soaking in ascorbic/citric acid and dipping in distilled water.An untreated sample was used as a control.A laser diode emitting at 670 nm with 3 mW power was used as light source.The backscattering relative laser area was used as an indicator for the light absorption into the tissue.The high result achieved on coefficient of determination R^(2)(>0.93)confirmed linear relationship between relative laser area and moisture content.Treatment with ascorbic acid gave the best prediction of the moisture content with the standard error of 5.7 and 8.8 for the estimated intercept and slope.The results showed a significant difference of lightness(L*values)during drying according to the different treatments.As a result,colour degradation did not have a significant influence on the absorption of light at 670 nm wavelength. | Giuseppe Romano Dimitrios Argyropoulos Klaus Gottschalk Emanuele Cerruto Joachim Müller | 2010 | International Journal of Agricultural and Biological Engineering2010，3，2： | 2 |
| 19 | TCO and light trapping in silicon thin film solar cells显示文摘 | Joachim Müller Bernd Rech Jiri Springer Milan Vanecek | 2004 | Solar Energy2004，，6： | 2 |
| 20 | Development of an inflatable solar dryer for improved postharvest handling of paddy rice in humid climates显示文摘Rice is the staple food for more than three billion people worldwide.Although considerable progress has been made with respect to improved breeds and production practices,losses during postharvest handling remain considerable.Drying and storage of paddy are two key stages where management can be improved.For rice,grain moisture content of 14%prevents microbiological activity,while a level of about 12%minimizes quality losses over prolonged storage periods.Due to the need for simple and economical technologies,an inflatable solar dryer(ISD)was developed based on adaptations of the Hohenheim-type solar tunnel dryer.To form a drying tunnel,transparent polyethylene(PE)film attaches by zipper to a reinforced black polyvinyl chloride(PVC)film.To reduce heat loss,a flexible multilayer floor was used along the drying area.The tunnel does not need a substructure as it is stabilized adequately from pressure created by two axial flow ventilators.During experiments,paddy was spread on the floor and mixed with a special roller bar.The ISD has been evaluated for paddy in the Philippines during both rainy and dry seasons and was subsequently optimized.Sun drying and shade drying were carried out in parallel for comparison and product was evaluated for moisture content and quality in terms of milling recovery and head rice yield.Moisture content was reduced from 23%to 14%within 26-52 h of continuous operation during the rainy season and 16%to 14%within 4-26 h of drying during the dry season.In both seasons,the final moisture content of 12%was reached after prolonged drying periods.Quality was not found to be affected with respect to drying treatment.The ISD showed advantages over sun drying,despite longer drying periods. | Ana Salvatierra-Rojas Marcus Nagle Martin Gummert Tom de Bruin Joachim Müller | 2017 | International Journal of Agricultural and Biological Engineering2017，10，3： | 2 |
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