|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Challenges in the diagnosis and treatment of gestational trophoblastic neoplasia worldwide显示文摘Gestational trophoblastic neoplasia(GTN) is a rare tumor that originates from pregnancy that includes invasive mole, choriocarcinoma(CCA), placental site trophoblastic tumor and epithelioid trophoblastic tumor(PSTT/ETT). GTN presents different degrees of proliferation, invasion and dissemination, but, if treated in reference centers, has high cure rates, even in multi-metastatic cases.The diagnosis of GTN following a hydatidiform molar pregnancy is made according to the International Federation of Gynecology and Obstetrics(FIGO)2000 criteria: four or more plateaued human chorionic gonadotropin(hCG)concentrations over three weeks; rise in hCG for three consecutive weekly measurements over at least a period of 2 weeks or more; and an elevated but falling hCG concentrations six or more months after molar evacuation. However,the latter reason for treatment is no longer used by many centers. In addition,GTN is diagnosed with a pathological diagnosis of CCA or PSTT/ETT. For staging after a molar pregnancy, FIGO recommends pelvic-transvaginal Doppler ultrasound and chest X-ray. In cases of pulmonary metastases with more than 1cm, the screening should be complemented with chest computed tomography and brain magnetic resonance image. Single agent chemotherapy, usually Methotrexate(MTX) or Actinomycin-D(Act-D), can cure about 70% of patients with FIGO/World Health Organization(WHO) prognosis risk score ≤ 6(low risk), reserving multiple agent chemotherapy, such as EMA/CO(Etoposide,MTX, Act-D, Cyclophosphamide and Oncovin) for cases with FIGO/WHO prognosis risk score ≥ 7(high risk) that is often metastatic. Best overall cure rates for low and high risk disease is close to 100% and > 95%, respectively. The management of PSTT/ETT differs and cure rates tend to be a bit lower. The early diagnosis of this disease and the appropriate treatment avoid maternal death,allow the healing and maintenance of the reproductive potential of these women. | Antonio Braga Paulo Mora Andréia Cristina de Melo Angélica Nogueira-Rodrigues Joffre Amim-Junior Jorge Rezende-Filho Michael J Seckl | 2019 | World Journal of Clinical Oncology2019，10，2： | 15 |
| 2 | Evaluation of the recovery of microbial functions during soil restoration using near infrared spectroscopy显示文摘 | Schimann H Joffre R Roggy J C | 2007 | Applied Soil Ecology2007，，37： | 1 |
| 3 | Supercritical fluid extraction of Moroccan (Timahdit) oil shale with water显示文摘 | EL HARFI K BENNOUNA C MOKHLISSE A BEN CHANAA M LEMEE L JOFFRE J AMBLES A | 1999 | J Anal Appl Pyrolysis1999，50，2： | 1 |
| 4 | Carbon based secondary and structural compounds in Mediterranean shrubs growing near a natural COz spring 显示文摘 | PENUELAS J CASTELLS E JOFFRE R | 2002 | Glob Change Biol2002，8，3： | 1 |
| 5 | MRI/CT x-ray comparison in the pre-operative evaluation of cancer of the larynx显示文摘 | Joffre P Giron J Fraqa J | 1988 | J Radiol1988，69，67： | 1 |
| 6 | Modelling transpiration in holm-oak savannah: caling up from the leaf to the tree scale显示文摘 | Infante J M Rambal S Joffre R | 1997 | Agricultural and Forest Meteorology1997，87，4： | 1 |
| 7 | Within-tree variation in transpiration in isolated evergreen oak trees:evidence in support of the pipe model theory显示文摘 | INFANTE J M MAUCHAMP A FERNNDEZ-ALS R JOFFRE R RAMBAL S | 2001 | Tree Physiology2001，21，6： | 1 |
| 8 | Carbon-based secondary and structural compounds in Mediterranean shrubs growing near a natural COz spring显示文摘 | Penuelas J Castells E Joffre R | 2002 | Global Change Biology2002，8，： | 1 |
| 9 | Experimental demonstration of a phased-array antenna optically controlled with phase and timedelays显示文摘 | DOLFI D JOFFRE P HUIGNARD J P | 1996 | Applied Optics1996，35，9： | 1 |
| 10 | 自然杀伤细胞的遗传缺失或高反应性不影响动脉粥样硬化发展显示文摘慢性炎症是动脉粥样硬化发展的重要因素,涉及先天免疫和适应性免疫。尽管一些研究已经评估了自然杀伤细胞(natural killer cells,NK)在动脉粥样硬化实验动物模型中的功能,但NK细胞是否可以抑制或促进动脉粥样硬化尚不清楚。先前研究的不足之处在于在靶向丧失或增强NK细胞功能方面缺乏特异性。 | 刘莉 叶鹏 Nour-Eldine W Joffre J Zibara K Giraud A Esposito B Zeboudj L Vilar J Terada M Bruneval P Vivier E Ait-Oufella H Mallat Z Ugolini S Tedgui A | 2017 | 中华高血压杂志2017，25，12： | 1 |
| 11 | Specific functional signature in soil macroinvertebrate biostructures 显示文摘 | Hedde M Lavene P Joffre R Jimenez J J Decaens T | 2005 | Functional Ecology2005，195，： | 1 |
| 12 | Adipose-derived cardiomyo-genic cells:in vitro expansion and functional improvement in amouse model of myocardial infarction显示文摘 | Leobon B Roncalli J Joffre C | 2009 | Cardiovasc Res2009，83，4： | 1 |
| 13 | Characterization and classification of Tarfaya kerogen (South Morocco) based on its oxidation products显示文摘 | HALIM M JOFFRE J AMBLES A | 1997 | Chem Geol1997，141，34： | 1 |
| 14 | CD4^+CD25^+ regulatory T lymphocytes in bone marrow transplantation显示文摘 | Joffre O Van Meerwijk J P | 2006 | Seminars Immunology2006，18，： | 1 |
| 15 | Drought con- trols over conductance and assimilation of a Mediterranean evergreen ecosystem: scaling from leaf to canopy显示文摘 | RAMBALS OURCIVAL J M JOFFRE R | 2003 | Global Change Biology2003，9，12： | 1 |
| 16 | Evaluation of the recovery of microbial functions during soil restoration using near-infrared spectroscopy显示文摘 | Schimann H Joffre R Roggy J C | 2007 | Applied Soil Ecology2007，37，3： | 1 |
| 17 | Experimental demonstration of a phased-array antenna optically controlled with phase and time delays显示文摘 | DOLFI D JOFFRE P HUIGNARD J P | 1996 | Applied Optics1996，35，9： | 1 |
| 18 | Hydroprocessing of substituted benzenes over a sulfided CoO-MoO3γ-Al2 O3 catalyst显示文摘 | MOREAU C JOFFRE J SAENZ C GENESTE P | 1990 | J Catal1990，122，2： | 1 |
| 19 | Effe cts of TGF-β1 on dental pupl cells in culture human tooth slice显示文摘 | MELIN M JOFFRE ROMEAS A FARGES J C | 2000 | J Dent Res2000，79，9： | 1 |
| 20 | Local inversion of VSP data 显示文摘 | Spencer T W Joffre J C | 1985 | Expanded Abstracts of 55^th Annual International SEG Meeting1985，3032，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员