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| 1 | Moving from control to elimination of schistosomiasis in sub-Saharan Africa:time to change and adapt strategies显示文摘Schistosomiasis is a water borne parasitic disease of global importance and with ongoing control the disease endemic landscape is changing.In sub-Saharan Africa,for example,the landscape is becoming ever more heterogeneous as there are several species of Schistosoma that respond in different ways to ongoing preventive chemotherapy and the inter-sectoral interventions currently applied.The major focus of preventive chemotherapy is delivery of praziquantel by mass drug administration to those shown to be,or presumed to be,at-risk of infection and disease.In some countries,regional progress may be uneven but in certain locations there are very real prospects to transition from control into interruption of transmission,and ultimately elimination.To manage this transition requires reconsideration of some of the currently deployed diagnostic tools used in surveillance and downward realignment of existing prevalence thresholds to trigger mass treatment.A key challenge will be maintaining and if possible,expanding the current donation of praziquantel to currently overlooked groups,then judging when appropriate to move from mass drug administration to selective treatment.In so doing,this will ensure the health system is adapted,primed and shown to be cost-effective to respond to these changing disease dynamics as we move forward to 2020 targets and beyond. | Louis-Albert Tchuem Tchuente David Rollinson JRussell Stothard David Molyneux | 2017 | Infectious Diseases of Poverty2017，6，1： | 8 |
| 2 | Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in Marolambo District, Madagascar显示文摘School-aged children(SAC)have a considerable burden of intestinal schistosomiasis in Madagascar yet its burden in pre-school aged children(PSAC)is currently overlooked.To assess the at-risk status of PSAC,we undertook a pilot epidemiological survey in June 2019 examining children(n=89),aged 2-4-years of balanced gender,in six remote villages in Marolambo District,Madagascar.Diagnosis included use of urine-circulating cathodic antigen(CCA)dipsticks and coproscopy of stool with duplicate Kato-Katz(K-K)thick smears. | Caitlin Sheehy Heather Lawson Emmanuel H.Andriamasy Hannah J.Russell Alice Reid Gina U.Raderalazasoa Graham Dodge Robbie Kornitschky James M.StJPenney Tahiry N.Ranaivoson Antsa Andria niaina Jenny S.Emmanoela Amaya L.Bustinduy JRussell Stothard Louis Andrianjaka Stephen A.Spencer | 2021 | Infectious Diseases of Poverty2021，10，3： | 2 |
| 3 | Building a global schistosomiasis alliance:an opportunity to join forces to fight inequality and rural poverty显示文摘Schistosomiasis,one of the 17 neglected tropical diseases listed by the World Health Organization,presents a substantial public health and economic burden.Of the 261 million people requiring preventive chemotherapy for schistosomiasis in 2013,92%of them lived in sub-Saharan Africa and only 12.7%received preventive chemotherapy.Moreover,in 2010,the WHO reported that schistosomiasis mortality could be as high as 280000 per year in Africa alone.In May 2012 delegates to the sixty-fifth World Health Assembly adopted resolution WHA65.21 that called for the elimination of schistosomiasis,and foresees the regular treatment of at least 75%of school age children in at-risk areas.The resolution urged member states to intensify schistosomiasis control programmes and to initiate elimination campaigns where possible.Despite this,in June 2015,schistosomiasis was indicated to have the lowest level of preventive chemotherapy implementation in the spectrum of neglected tropical diseases.It was also highlighted as the disease most lacking in progress.This is perhaps unsurprising,given that it was also the only NTD with access to drug donations but without a coalition of stakeholders that collaborates to boost commitment and implementation.As a consequence,and to ensure that the WHO NTDs Roadmap Targets of 2012 and World Health Assembly Resolution WHA65.21 are met,the Global Schistosomiasis Alliance(GSA)has been set up.Diverse and representative,the GSA aims to be a partnership of endemic countries,academic and research institutions,international development agencies and foundations,international organizations,non-governmental development organizations,private sector companies and advocacy and resource mobilisation partners.Ultimately,the GSA calls for a partnership to work for the benefit of endemic countries by addressing health inequity and rural poverty. | Lorenzo Savioli Marco Albonico Daniel G.Colley Rodrigo Correa-Oliveira Alan Fenwick Will Green Narcis Kabatereine Achille Kabore Naftale Katz Katharina Klohe Philip TLoVerde David Rollinson JRussell Stothard Louis-Albert Tchuem Tchuente Johannes Waltz Xiao-Nong Zhou | 2017 | Infectious Diseases of Poverty2017，6，1： | 1 |
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