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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Role of insulin resistance in uric acid nephrolithiasis显示文摘Metabolic syndrome has been implicated in the pathogenesis of uric acid stones.Although not completely understood,its role is supported by many studies demonstrating increased prevalence of uric acid stones in patients with metabolic syndrome and in particular insulin resistance,a major component of metabolic syndrome.This review presents epidemiologic studies demonstrating the association between metabolic syndrome and nephrolithiasis in general as well as the relationship between insulin resistance and uric acid stone formation,in particular.We also review studies that explore the pathophysiologic relationship between insulin resistance and uric acid nephrolithiasis. | Hanhan Li Dane E Klett Raymond Littleton Jack S Elder Jesse D Sammon | 2014 | World Journal of Nephrology2014，3，4： | 6 |
| 3 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 4 | A randomized, placebo-controlled, multicenter study of the safety and efficacy of a new polyethylene glycol laxative显示文摘 | Jack A DiPalma Peter H DeRidder Roy C Orlando Byron E Kolts Mark vB Cleveland | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
| 5 | Vulvar granular cell tumor显示文摘Granular cell tumors are rare,usually benign,soft tissue neoplasms of neural origin.They occur more often in females than males,the peak age incidence is in the fourth through fifth decades.They can occur anywhere in the body with up to 15% situated in the vulva.The commonest presentation is as an asymptomatic mass.Microscopic findings are usually sufficient,but immunohistochemistry can also be helpful in confirming the diagnosis.The vulvar tumors are benign in 98% of cases with 2% reported as malignant.In this case report we describe a woman with a granular cell tumor confirmed by biopsy who underwent excision of the mass but with focal extension to the resection margin on microscopy.Our recommendation of re-excision was declined.Since it is not uncommon with these tumors to find groups of tumor cells extending beyond the macroscopic limits of growth,we conclude that it is advisable to have margins assessed intraoperatively by frozen section such that further excision can be performed for positive margins.Our patient has been followed for 18 mo without recurrence,should the tumor recur,re-excision,with frozen section control,is indicated.Recurrence rates are reported as 2%-8% with clear margins and 20% with positive margins. | Michel E Rivlin G Rodney Meeks Mohamed A Ghafar Jack R Lewin | 2013 | World Journal of Clinical Cases2013，1，4： | 2 |
| 6 | Development and characterization of PCR markers in cucumber显示文摘 | Gennaro F Jack E S Sang M C | 2002 | Hort Sci2002，127，4： | 1 |
| 7 | Sources of volume flexibility and their impact on performance显示文摘 | Jack E P Raturi A | 2002 | Journal of Operations Management2002，，20： | 1 |
| 8 | Electrohydraulic Pressure Control 显示文摘 | Jack L Johnson P E | 2005 | Hydraulics & Pneumatics2005，，5： | 1 |
| 9 | Viscosity changes during initial stages of hydrolysis of gelatin by hydrochloric acid and sulfonated polystyrene catalysis 显示文摘 | Paulson Jack C Deatherage F E | 1955 | Archives of Biochemistry and Biophysics1955，56，2： | 1 |
| 10 | Self-reported abstinence effects in the first month after smoking cessation显示文摘 | WARD M M SWAN G E JACK L M | 2001 | Addict Behav2001，26，3： | 1 |
| 11 | Tectonostratigraphic development of the Interior Sudan Rifts,Central Africa显示文摘 | TIM R Mchargue TOM L Heidrick JACK E Livingston | 1992 | Tectonophysics1992，21，3： | 1 |
| 12 | Volume flexible stralegics in health services: a research framework显示文摘 | Jack E P Powers T L | 2004 | Production and Operations Management2004，，13： | 1 |
| 13 | Sources of Volume Flexibility and Their Impact on Performance 显示文摘 | Jack E P Raturi A | 2002 | Journal of Operations Management2002，20，5： | 1 |
| 14 | An OD Intervention To Install Participative Management in a Bureaucratic Organization显示文摘 | JACK E TAYLOR ELIZABETH BERTINOT | 1973 | Training and Development Journal1973，，： | 1 |
| 15 | The CORDIC trigonometric computing technique 显示文摘 | Voider Jack E | 1959 | IEEE Transactions on Electronic Computers1959，8，： | 1 |
| 16 | The homeotic gene APETALA3 of Arabidopsis thaliana encodes a MADS-box and is expressed in petals and stamens 显示文摘 | JACK T BROCKMAN L L MEYEROWITZ E M | 1992 | Cell1992，68，4： | 1 |
| 17 | Infrared microscopy thermal characterization of opposing carbon nanotube arrays显示文摘 | Hu X Jack Matthew A Panzer Kenneth E Goodson | 2007 | J Heat Trans2007，129，： | 1 |
| 18 | Obesity and hypertension: mechanisms, cardio-renal consequences, and therapeutic approaches显示文摘 | Reisin E Jack AV | 2009 | The Medical Clinics of North America2009，93，3： | 1 |
| 19 | Measuring and comparing volume flexibility in the capital goods industry显示文摘 | Jack E P Raturi A S | 2003 | Production and Operations Management2003，，12： | 1 |
| 20 | Progesterone receptor expression in neurofibromas 显示文摘 | Margaret E Mc Laughlin Tyler Jacks | 2003 | Cancer Res2003，63，： | 1 |
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