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| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories 显示文摘 | Jacobson L H Kelly P H Bettler B | 2006 | J Neurosci2006，26，34： | 1 |
| 3 | Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production显示文摘 | Edgerton D S Jacobson P B Opgenorth T Jet cd | 2006 | Metabolism2006，55，9： | 1 |
| 4 | Environmental factors determining the trace-level sorption of silver and thallium to soils显示文摘 | JACOBSON A R MCBRIDE M B BAVEYE P | 2005 | Science of the Total Environment2005，345，123： | 1 |
| 5 | Prognostic value of HIV-1 RNA,CD4 cell count,and CD4 Cell count slope for progression to AIDS and death in untreated HIV-1infection显示文摘 | Mellors J W Margolick J B Phair J P Rinaldo C R Detels R Jacobson L P Mu noz A | 2007 | JAMA2007，297，21： | 1 |
| 6 | Development of the Tinnitus Handicap Inventory显示文摘 | NEWMAN C W JACOBSON G P SPITZER J B | 1996 | Arch Otolaryngol Head Neck Surg1996，122，： | 1 |
| 7 | A new spin on an old model:in vivo evaluation of disease progression by magnetic resonance imaging with respect to standard inflammatory parameters and histopathology in the adjuvant arthritic rat 显示文摘 | Jacobson P B Morgan S J Wilcox D M | 1999 | Arthritis Rheum1999，42，10： | 1 |
| 8 | A new spin on an old model: In vivo evaluation of disease progression magnetic resonance imaging with respect to standard inflammatory parameters and histopathology in the adjuvant arthritic rat 显示文摘 | Jacobson P B Borgan S J Wilcox D M | 1999 | Arthritis Rheum1999，42，： | 1 |
| 9 | Pharmacological characterization of thepseudopterosins: novel anti-inflammatory natural products isolated form the Caribbean soft coral, Pseudopterogorgia elisabethae 显示文摘 | Mayer M S A Jacobson P B Fenical W | 1998 | Pharm Lett1998，62，26： | 1 |
| 10 | Development of the tinnitus handicap inventory显示文摘 | Newman C W Jacobson G P Spitzer J B | 1996 | Arch Otolaryngol Head Neck Surg1996，122，： | 1 |
| 11 | A new spin on an old model: In vivo evaluation of disease progression by magnetic resonance imaging with respect to standard inflammatory parameters and histopathology in the adjuvant arthritic rat 显示文摘 | Jacobson P B Borgan S J Wilcox D M | 1999 | Arthritis Rheum1999，42，10： | 1 |
| 12 | Environmental factors determining the trace-level sorption of silver and thallium to soils显示文摘 | Jacobson A R McBride M B Baveye P | 2005 | Science of the Total Environment2005，345，： | 1 |
| 13 | Hepatic glucocortlcoid receptor antagonism is sufficient to reduce elevated hepatic glucoseoutput andimprovaglucose control in animal models of type 2 diabetes 显示文摘 | Jacobson P B Von Geldem T W Ohman L | 2005 | J Pharmacol Exp Ther2005，314，1： | 1 |
| 14 | A new spin on an old model:in vivo evaluation of disease progression by magnetic resonance imaging with respect to standard inflammatory parameters and histopathology in the adjuvant arthritic rat 显示文摘 | Jacobson P B Borgan S J Wilcox D M | 1999 | Arthritis Rheum1999，42，10： | 1 |
| 15 | A new spin on an old model:In vivo evaluation of disease progression by magnetic resonance imaging with respect to standed inflammatory parameters and histopathology in the adjuvant arthritic rat 显示文摘 | Jacobson P B Morqan S J Wilcox DM | 1999 | Arthritis Rheum1999，42，10： | 1 |
| 16 | Energy-based analysis and prediction of the orientation between light- and heavy-chain antibody variable domains显示文摘 | Narayanan A Sellers B D Jacobson M P | 2009 | J Mol Biol2009，388，： | 1 |
| 17 | Development of the tinnitus handicap inventory显示文摘 | NEWMAN C W JACOBSON G P SPITZER J B | 1996 | Archvotolaryngol Head Neck Surg1996，122，： | 1 |
| 18 | Environmental factors determining the trace-level sorption of silver and thallium to soils 显示文摘 | JACOBSON A R MCBRIDE M B BAVEYE P STEENHUIS T S | 2005 | Sci Total Env2005，345，： | 1 |
| 19 | Quality assured measurements of animal building emissions:odor concentrations显示文摘 | Jacobson L D Hetchler B P Schmidt D R | 2008 | Journal of the Air & Waste Management Association2008，58，6： | 1 |
| 20 | Development of the tinnitus handicap inventory显示文摘 | NEWMAN C W JACOBSON G P SPITZER J B | 1996 | Arch Otolaryngol Head Neck Surg1996，122，： | 1 |
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