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| 1 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 2 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 3 | Colored ultrathin hybrid photovoltaics with high quantum efficiency显示文摘Most current solar panels are fabricated via complex processes using expensive semiconductor materials,and they are rigid and heavy with a dull,black appearance.As a result of their non-aesthetic appearance and weight,they are primarily installed on rooftops to minimize their negative impact on building appearance.The large surfaces and interiors of modern buildings are not efficiently utilized for potential electric power generation.Here,we introduce dual-function solar cells based on ultrathin dopant-free amorphous silicon embedded in an optical cavity that not only efficiently extract the photogenerated carriers but also display distinctive colors with the desired angle-insensitive appearances.Light-energy-harvesting colored signage is demonstrated.Furthermore,a cascaded photovoltaics scheme based on tunable spectrum splitting can be employed to increase power efficiency by absorbing a broader band of light energy.This study pioneers a new approach to architecturally compatible and decorative thin-film photovoltaics. | Kyu-Tae Lee Jae Yong Lee Sungyong Seo L Jay Guo | 2014 | Light(Science & Applications)2014，3，1： | 4 |
| 4 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 5 | Ultra precision polishing of Si3 N4 ceramics using magnetorheological fluids and diamond abrasives 显示文摘 | DONG-WOO KIM J-W L MYEONG-WOO CHO YOUNG- JAE SHIN | 2009 | Journal of Ceramic Processing Research2009，10，3： | 1 |
| 6 | Calcium compounds to improve gel quality of Pacific Whiting and Alaska Pollock surimi显示文摘 | Nahmgull L Jae W P | 1998 | J Food Sci1998，63，6： | 1 |
| 7 | Effect of apple pomace on the liver damage in bromobenzene-treated rats显示文摘 | Shin K C Kyeok K Jae H L | 2001 | Food Science and Biotechnology2001，10，3： | 1 |
| 8 | Atomic scale investigation on the distribution of boron in medium carbon steels by atom probe tomography and EELS显示文摘 | JAE B S GIL H G NAMS L | 2010 | Ultramicroscopy2010，110，7： | 1 |
| 9 | Improved method for efficient production of biodiesel from palm oil显示文摘 | RAHMAN TALUKDER M M MIN BEATRICE K L PUAY SONG O PUAH S CHUAN WU J JAE WON C CHOW Y | 2008 | Energy Fuels2008，22，1： | 1 |
| 10 | Lack of association between vitamin D receptor genotypes and osteoporosis in Korean显示文摘 | Sung K L Young S P Jae M P | 1995 | J Clin Endocrinol Metab1995，80，12： | 1 |
| 11 | A new process for the synthesis of diphenyl carbonate from dimethyl carbonate and phenol over heterogeneous catalysts显示文摘 | Won B K Jae S L | 1999 | Catalyst Letter1999，59，1： | 1 |
| 12 | The relationship between cytokines and HPV - 16 ,HPV - 16 E6,E7 and high - risk HPV viral load in the uterine cervix显示文摘 | Seung H S Jae K L O ye S S | 2007 | Gynecol O ncol2007，104，3： | 1 |
| 13 | An Overview of Peak-to-average Power Ratio Reduction Techniques for Multicarrier Transmission显示文摘 | SEUNG H H JAE H L | 2005 | IEEE Wireless Communications2005，12，02： | 1 |
| 14 | Cellular change and calloseaccumulation in zygotic embryos of Eleutherococcus senticosuscaused by plasmolyzing pretreatment result in high frequency ofsingle- cell- derived somatic embryogenesis显示文摘 | You X L Jae Seon Y Choi Y E | 2006 | Protoplasma2006，227，： | 1 |
| 15 | Modi{ied selected mapping technique for PAPR reduction of coded OFDM signal 显示文摘 | Seung H H Jae I-I L | 2004 | IEEE Trans Broadcast2004，50，33： | 1 |
| 16 | Dayanand agasarproduction,characterization and application of kera-tinase from Streptomyces gulbargensis显示文摘 | Dastager G S Jae C L Li W J | 2009 | Biore-source Technology2009，100，： | 1 |
| 17 | Percutaneous needle as-piration biopsy (PCNAB) of lung lesions :5 years resultswith focusing on repeat PCNAB显示文摘 | Jae L Young AB Dong GK | 2010 | Europ J Radiol2010，73，3： | 1 |
| 18 | Bankruptcy prediction using support vector machine with optimal choice of kernel function parameters显示文摘 | Jae H M Y C L | 2005 | Expert Systems with Application2005，28，4： | 1 |
| 19 | Derivation of Male Germ Cells From Bone Marrow Stem Cells显示文摘 | Karim N Jae Ho L Drusenheimer N | 2006 | Laboratory Investigation2006，86，： | 1 |
| 20 | Aircarrier liability for delay : a plea to return to international uniformity显示文摘 | Jae W L Wheeler J C | 2012 | Journal of Air Law and Commerce2012，77，1： | 1 |
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