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| 1 | Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and MRI显示文摘AIM: To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVueüà-enhancement; and to compare this method with computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: One hundred and thirty four patients with one focal liver lesion detected in baseline ultrasound (US) were examined with conventional US, contrastenhanced US (n = 134), contrast-enhanced CT (n = 115) and/or dynamic contrast-enhanced MRI (n = 70). The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The f inal diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions. RESULTS: In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVueüà -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available (n = 30), sensitivity was 95.5% (CEUS), 72.2% (CT) and 81.8% (MRI), and specif icity was 75.0% (CEUS), 37.5% (CT) and 42.9% (MRI). The sensitivity and specif icity of CEUS for the identif ication of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%. CONCLUSION: SonoVueüà-enhanced sonography emerges as the most sensitive, most specif ic and thus most accurate imaging modality for the characterization of focal liver lesions. | Hervé Trillaud Jean-Michel Bruel Pierre-Jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis | 2009 | World Journal of Gastroenterology2009，15，30： | 34 |
| 2 | 美国人眼中21世纪的中国医学教育显示文摘 | Gerald S Lazarus Audrey F Jakubowski | 2001 | 中华医学杂志2001，81，15： | 16 |
| 3 | Plasma homocysteine is a determinant of tissue necrosis factor-α in hypertensive patients显示文摘 | P. Bogdanski D. Pupek-Musialik J. Dytfeld M. Lacinski A. Jablecka H. Jakubowski | 2007 | Biomedicine & Pharmacotherapy2007，，6： | 3 |
| 4 | Role of homocysteine in aortic calcification and osteogenic cell differentiation显示文摘 | Ann Van Campenhout Corey S. Moran Adam Parr Paula Clancy Catherine Rush Hieronim Jakubowski Jonathan Golledge | 2008 | Atherosclerosis2008，，2： | 2 |
| 5 | 胃肠外应用COX1/COX2抑制剂终止伴触诱发痛的偏头痛和发展中的中枢致敏作用 | Jakubowski M. Levy D. Goor-Aryeh I. R. Burstein 邓剑平 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，11： | 2 |
| 6 | A loeal,high-density,single-nucleotide polymorphism map used to clone Caenorhabditis elegans cdf-1 显示文摘 | Jakubowski J Komfeld K | 1999 | Genetics1999，153，2： | 1 |
| 7 | The molecular basis of homocysteine thiolactone- mediated vascular disease显示文摘 | Jakubowski H | 2007 | Clin Chem Lab Med2007，45，1： | 1 |
| 8 | The Sheffield model of subarachnoid hemorrhage in rats显示文摘 | Veelken JA Laing RJ Jakubowski J | 1995 | Stroke1995，26，7： | 1 |
| 9 | The pathophysiological hypothesis of homocys- teine thiolactone-mediated vascular disease显示文摘 | Jakubowski H | 2008 | J Physiol Pharma- col2008，9，： | 1 |
| 10 | Molecular basis of homocysteine toxicity in humans 显示文摘 | Jakubowski H | 2004 | Cell Mol Life Sci2004，61，47： | 1 |
| 11 | Pathophysiological consequences of homocysteine excess显示文摘 | Jakubowski H | 2006 | J Nutr2006，136，： | 1 |
| 12 | The pathophysiological hypothesis of homoc-ysteine thiolactone-mediated vascular disease显示文摘 | Jakubowski H | 2008 | J PhysiolPharmacol2008，59，9： | 1 |
| 13 | Reliabilityof endosonography in evaluation of anal fistulae and abscesses显示文摘 | Sudot-Szopinskal I Gessla J Jakubowski W | 2002 | Acta Radiol2002，43，： | 1 |
| 14 | Elemental tagging in inorganic mass spectrometric bioanalysis显示文摘 | J. Bettmer N. Jakubowski A. Prange | 2006 | Analytical and Bioanalytical Chemistry2006，，1： | 1 |
| 15 | The problemsof pulse excitation in electromagnetic flowmeters显示文摘 | MICHALSKI A JAKUBOWSKI J WATRAL Z | 2013 | IEEEInstrumentation and Measurement Magazine2013，16，5： | 1 |
| 16 | Application of a hexapole collision and reaction cell in ICP-MS Part Ⅱ:Analytical figures of merit and first applications显示文摘 | FELDMANN I JAKUBOWSKI N THOMAS C | 1999 | Fresenius'' Journal of Analytical Chemistry1999，365，5： | 1 |
| 17 | Molecular basis of homocysteine toxicity in humans显示文摘 | Jakubowski H | 2004 | Cell Mol Life Sci2004，61，： | 1 |
| 18 | The Sheffield model of subarachnoid hemorrhage in rats 显示文摘 | Vcelken JA Laing RJ Jakubowski J | 1995 | Stroke1995，26，7： | 1 |
| 19 | Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors显示文摘 | Jakubowski M Levy D Itay Goor-Aryeh I | 2005 | Headache2005，45，： | 1 |
| 20 | A neural mechanism for ex- acerbation of headache by light 显示文摘 | Noseda R Kainz V Jakubowski M | 2010 | Nat Neurosci2010，13，： | 1 |
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