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| 1 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 2 | The retrograde in tremedullarysupracindylar nail:an alrernarive in the treatment of distal femoral fractures in the elderly显示文摘 | Jan Zing HMJ Stockan B Van Damme C | 1998 | Arch Orthop trauma Surg1998，118，1： | 1 |
| 3 | Bioenergy in the United States: progress and possibilities显示文摘 | JIM C JAN B | 2000 | Biomass & Biology2000，，18： | 1 |
| 4 | DNA sequencing by capillary electrophoresis with replaeeable linear polyacrylamide and laser-induced fluorescence detection显示文摘 | MARIE C R JAN B ALEXEI B | 1993 | Anal Chem1993，65，20： | 1 |
| 5 | Co-morbidities of vertiginous diseases显示文摘 | Jan C W Otmar B Uta F | 2009 | BMC Neurol2009，9，： | 1 |
| 6 | Cardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve显示文摘 | ARTHUR B EMILE C JAN L et al | 1997 | Heart1997，78，5： | 1 |
| 7 | Modeling ofgeneric slung load system 显示文摘 | MORTEN B JAN D B ANDERS C | 2009 | Journal of Guidance Control and Dynamics2009，32，2： | 1 |
| 8 | A Study of Innovation Design on Taiwan Culture Creative Product: A Case Study of the Facial Mask of Ba Ja Jang显示文摘 | CHEN C H CHEN B C JAN C D | 2009 | Lecture Notes in Computer Science2009，，： | 1 |
| 9 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 10 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 11 | A biosensorbased on co - immobilized L - glutamate oxidase and L - glutamate dehydrogenase for analysis of monosodium glutamate in food 显示文摘 | AN JAN K B PARIMAL C UTPAL R | 2006 | Bioscns Bioelectron2006，21，： | 1 |
| 12 | Serial blood lactate levels can predict the development of multiple organ failure following septic shock显示文摘 | Jan B Philippe G Michel C | 1996 | Am J Surg1996，171，2： | 1 |
| 13 | Effect of sorption kinetics on nickel toxicity in methanogenic granular sludge 显示文摘 | JAN B FERNANDO G F Alba B C | 2010 | Journal of Hazardous Materials2010，180，： | 1 |
| 14 | Adaptive fuzzy mixed H2/H∞ attitude control of spacecraft显示文摘 | Chen B S Wu C S Jan Y W | 2000 | IEEE Trans on Aerospace and Electronic Systems2000，36，4： | 1 |
| 15 | Construction of an RFLP linkage map for cultivated sunflower 显示文摘 | Jan C C Vick B A Miller J F | 1998 | Theor Appl Genet1998，96，： | 1 |
| 16 | Ambulatory Arterial Stiffness Index Predicts Stroke in a General Population显示文摘 | Tine W Hansena B C Jan A | 2006 | Hypertens2006，24，： | 1 |
| 17 | Momentmethod analysis of side-wall inclined Slots in Rectangular Waveguide显示文摘 | Jan C G Hsu P Wu R B | | 0，，： | 1 |
| 18 | Variational Analysis of Inclined Slots in the Narrow Wall of a Rectangular Waveguide显示文摘 | Jan C G Wu R B Hsu P | | 0，，： | 1 |
| 19 | Passively mode-locked diode laser with optimized dispersion man- agement 显示文摘 | Jan C B Rouven O H P Benjamin D | 2015 | IEEE Journal of Selected Topics in Quan- tum Electronics2015，21，11： | 1 |
| 20 | Epidemiology of nosocomial bloodstream infection in Belgium, 1992-1996显示文摘 | Ronveaux O Jans B Suetens C | 1998 | Eur J clin Microbiol Infect Dis1998，17，10： | 1 |
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