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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Effect of Ca on the solubility and molecular size distribution of DOC and Cu binding in soil solution samples显示文摘 | Romkens Paul F A M Jan Dolfing | 1998 | Environ Sci Technol1998，32，： | 1 |
| 3 | Brick kiln exhaust as a source of polycyclic aromatic hydrocarbons (PAHs) in the surrounding soil and plants: A case study from the city of Peshawar显示文摘 | Jan F A Khan S lshaq M | 2013 | Arabian Journal of Geosciences2013，7，1： | 1 |
| 4 | Emphysema and pneumothorax after percutaneous tracheostomy: case reports and an anatomic study显示文摘 | Bernard G F Jacques A van V Jan G K | 2004 | Chest2004，125，： | 1 |
| 5 | River flow forecasting using wavelet and cross-wavelet transform models 显示文摘 | Jan F A | 2008 | Hydrological Process2008，22，： | 1 |
| 6 | A DC-DC charge pump design based on voltage doublers显示文摘 | Starzyk J A Jan Y W Qiu F J | 2001 | IEEE Trans on Circuit Syst I2001，48，： | 1 |
| 7 | PRISMA-DB A parallel main memory relational DBMS 显示文摘 | PETER M G A CAREL A V D B JAN F | 1992 | IEEE Transactions on Knowledge and Data Engineering1992，4，6： | 1 |
| 8 | Application of ionic liquids in analytical chemistry 显示文摘 | LIU J F JAN A J JIANG G B | 2005 | Trends Anal Chem2005，24，1： | 1 |
| 9 | Mathematical modeling of diesel-electric propulsion systems for marine vessels显示文摘 | Jan F H ALF K A THOR I F | 2001 | Mathematical and Computer Modeling of Dynamical Systems2001，7，1： | 1 |
| 10 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 11 | Demonstration of rennin mRNA, angiotensinogen mRNA, and angiotensin conver- ting enzyme mRNA expression in the human eye: evidence for an intraocular renin-angiotensin system 显示文摘 | Wagner J Jan Danser A H Derkx F H | 1996 | Br J Ophthalmol1996，80，2： | 1 |
| 12 | Construction of an RFLP linkage map for cultivated sunflower 显示文摘 | Jan C C Vick B A Miller J F | 1998 | Theor Appl Genet1998，96，： | 1 |
| 13 | Evaluation of follicular oxidant - antioxidant balance and oxidative damage during reproductive aeyclicity in water Buffalo 显示文摘 | JAN M H DAS G K KHAN F A | 2014 | Asian Pacific Journal of Reproduction2014，3，1： | 1 |
| 14 | Gastric glomus tumor: of the literature 显示文摘 | Huang C C Yu F J Jan C M et a case report and review al | 2010 | The Kaohsiung journal of medical sciences2010，26，6： | 1 |
| 15 | River flow forecasting using wavelet and cross-wavelettransform models 显示文摘 | Jan F A | 2008 | Hydrological Process2008，22，： | 1 |
| 16 | Unilateral nevoid telangiectasia syndrome: a case report and review of the literature显示文摘 | Wenson SF Jan F Sepehr A | 2011 | Dermatol Online J2011，17，5： | 1 |
| 17 | Analysis of impairmentsinfluencing gait velocity and asymmetry of hemiplegic patientsafter mild to moderate stroke显示文摘 | HSU A L TANG P F JAN M H | 2003 | Arch Phys Med Rehabil2003，84，8： | 1 |
| 18 | Analysis of impairments influencing gant velocity and asymmentry of hemiplegic patients after mild to moderate stroke 显示文摘 | Hsu A L Tang P F Jan M H | 2003 | Arch Phys Rehabil2003，84，8： | 1 |
| 19 | A direct PCR detection method for clostridium tyrobutyricum spores in up to 100 Milliliters of raw milk显示文摘 | LIEVE M F H JAN H G E De B GUIDO M A V J W | 1995 | Appl Environ Microbiol1995，12，61： | 1 |
| 20 | A Comparative Study of Patent Sequence Databases显示文摘 | Piet Jan Andree a Mark F Harper Stephane Nauche | 2008 | World Patent Information2008，，： | 1 |
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