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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 3 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 4 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 5 | Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)显示文摘 | Claudia Allemani Hannah K Weir Helena Carreira Rhea Harewood Devon Spika Xiao-Si Wang Finian Bannon Jane V Ahn Christopher J Johnson Audrey Bonaventure Rafael Marcos-Gragera Charles Stiller Gulnar Azevedo e Silva Wan-Qing Chen Olufemi J Ogunbiyi Bernard R | 2015 | The Lancet . 2015 (9972)2015，，： | 2 |
| 6 | Hematopoietic AMPK [Beta]1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity显示文摘 | Galic Sandra Fullerton Morgan D Schertzer Jonathan D Sikkema Sarah Marcinko Katarina Walkley Carl R Izon David Honeyman Jane Chen Zhi-Ping van Denderen Bryce J Kemp Bruce E Steinberg Gregory R | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 7 | Cancer stem cells in solid tumours: accu- mulating evidence and unresolved questions 显示文摘 | Jane E Geoffrey | 2008 | Nature re- views(Cancer)2008，10，8： | 1 |
| 8 | Changes oflipid composition and saturation level in leaves and rootsfor heat-stressed and heat-acclimated creeping bent-grass显示文摘 | JANE L A RKINDA L E HUANG B R | 2004 | Environmental and Experimental Botany2004，51，： | 1 |
| 9 | Practical Free- Space Quantum Key Distribution over 10kin in Daylight and at Night显示文摘 | Richard J Hughes Jane E Nordholt | 2002 | New Journal of Physics2002，，4： | 1 |
| 10 | An energetic orphan in an endocrine tissue: A revised perspective of the function of estrogen receptor‐related receptor alpha in bone and cartilage显示文摘 | Edith Bonnelye Jane E Aubin | 2013 | J Bone Miner Res2013，，2： | 1 |
| 11 | CD40-CD40L and platelet function显示文摘 | | 2003 | Circulation Research2003，92，： | 1 |
| 12 | Developmental changes in enzymes of flavouoid biosynthesis in the skins of red and green apple cultivators 显示文摘 | Carolyn E L Jane E L John R L | 1996 | Sei Food Agric1996，71，： | 1 |
| 13 | How to investigate and analyse clinical incidengts:Clinical risk unit and association of litigation and risk management protocol显示文摘 | Vincent C Taylor-Adams S Jane Chapman E | 2000 | British Medical Journal2000，32，5： | 1 |
| 14 | The effect of intracytoplasmic sperm injection and semenparameters on blastocyst development in vitro显示文摘 | Jane E Miller T Smith T | 2001 | Hum Reprod2001，16，5： | 1 |
| 15 | Spinal cord injury with-out radiographic abnormalities in children显示文摘 | Pang D Janes E Wicberger J | 1987 | Pediatrics1987，57，1： | 1 |
| 16 | Gas chromatography olfactometry of dairy products 显示文摘 | Jane E F Terry E A | 1998 | Dairy Journal1998，8，3： | 1 |
| 17 | Waterbased crosslinkable surface coatings 显示文摘 | Richard J Esser Janes E | 1999 | Progress in Organic Coatings1999，，36： | 1 |
| 18 | A phase-Ⅰ-Ⅱtrial of lovastatin for anaplastic astrocytoma and glioblastoma multiforme显示文摘 | Larner J Jane J Laws E | 1998 | Am J Clin Oncol1998，21，6： | 1 |
| 19 | Absorptive capacity,learning,and performance in international joint ventures显示文摘 | P J LANE JANE E SALK MARJORIE A LYLES | | 0，，08： | 1 |
| 20 | DNA mismatch repair initiates 6-thioguanine induced autophagy through p53 activation in human tumor cells显示文摘 | Zeng XH Yan T Jane E | 2007 | ClinCancerRes2007，13，4： | 1 |
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