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| 1 | Combined cell-based therapy strategies for the treatment of Parkinson's disease:focus on mesenchymal stromal cells显示文摘Parkinson’s disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia nigra.Levodopa is an effective and well-tolerated dopamine replacement agent.However,levodopa provides only symptomatic improvements,without affecting the underlying pathology,and is associated with side effects after long-term use.Cell-based replacement is a promising strategy that offers the possibility to replace lost neurons in Parkinson’s disease treatment.Clinical studies of transplantation of human fetal ventral mesencephalic tissue have provided evidence that the grafted dopaminergic neurons can reinnervate the striatum,release dopamine,integrate into the host neural circuits,and improve motor functions.One of the limiting factors for cell therapy in Parkinson’s disease is the low survival rate of grafted dopaminergic cells.Different factors could cause cell death of dopaminergic neurons after grafting such as mechanical trauma,growth factor deprivation,hypoxia,and neuroinflammation.Neurotrophic factors play an essential role in the survival of grafted cells.However,direct,timely,and controllable delivery of neurotrophic factors into the brain faces important limitations.Different types of cells secrete neurotrophic factors constitutively and co-transplantation of these cells with dopaminergic neurons represents a feasible strategy to increase neuronal survival.In this review,we provide a general overview of the pioneering studies on cell transplantation developed in patients and animal models of Parkinson’s disease,with a focus on neurotrophic factor-secreting cells,with a particular interest in mesenchymal stromal cells;that co-implanted with dopaminergic neurons would serve as a strategy to increase cell survival and improve graft outcomes. | Jannette Rodríguez-Pallares María García-Garrote Juan A.Parga JoséLuis Labandeira-García | 2023 | Neural Regeneration Research2023，18，3： | 2 |
| 2 | A comparison of noise sensitivity of nine QRS detection algorithms显示文摘 | Freisen G M Jannett T C Djadallah M A | 1990 | IEEE Trans Biomed Eng1990，37，1： | 1 |
| 3 | Compound action potentials recorded from the exposed eighth nerve in patients with intractable tinnitus 显示文摘 | Moler A R Moler M B Jannetts P J | 1992 | Laryngoscope1992，102，2： | 1 |
| 4 | The longtermoutcome of microvascular decompression for trigeminal neuor-algia显示文摘 | Barker FG Jannette PJ Bissonette DJ | 1996 | N Engl J Med1996，334，17： | 1 |
| 5 | Comparison of the noise sensitivity of nine QRS detection algorithms显示文摘 | Jannett T C Jadallah M A | 1990 | IEEE Trans on Biomed Eng1990，37，1： | 1 |
| 6 | An application of Optimal Control to the Economics of Recycling显示文摘 | Jannett Highfill and Michael McAsey | 2001 | SIAM Review2001，，： | 1 |
| 7 | Comparison of the noise sensitivity of nine QRS detection algorithms显示文摘 | Friensen G M Jannett T C Jadallah M A | 1990 | IEEE Trans on Biomed Eng1990，37，1： | 1 |
| 8 | A comparison of the noise sensitivity of nine QRS detection algorithms显示文摘 | Friesen GM Jannett TC Jadallah MN | 1990 | IEEE Trans Biomed Eng1990，37，1： | 1 |
| 9 | A comparison of the noise sensitivity of nine QRS detection algorithms显示文摘 | Gary M Friesen Thomas C Jannett Manal Afify Jadallah | 1990 | IEEE Transactions on Biomedical Engineering1990，37，1： | 1 |
| 10 | Topoisomerase IIα and other drug resistance markers in advanced non-small cell lung cancer显示文摘 | Anne-Marie CD Jannette AD Simone S | 2001 | Lung Cancer2001，32，： | 1 |
| 11 | A cyanobacterium lacking iron superoxide dismutase is sensitized to oxidative stress induced with methyl viologn but is not sensitized to oxidative stress induced with norflurazon显示文摘 | DAVID J THOMAS J JANNETTE B | 1998 | Plant Physiol1998，116，： | 1 |
| 12 | A comparison of the noise sensitivity of nine QRS detection algorithms 显示文摘 | FRIESEN G M JANNETT T C | 1990 | IEEE Transactions on Biomedical Engineering1990，37，1： | 1 |
| 13 | The long-term outcome of microvascular decompression for trigeminal neuralgia显示文摘 | Jannette PJ Bissonette DJ | 1996 | N Engl J Med1996，334，17： | 1 |
| 14 | Neurogenic hypertension:Eti-ology and Surgical显示文摘 | Jannetts PJ Segal R Wolfson SK | 1985 | Ann Surg1985，201，： | 1 |
| 15 | The long- term out-come of microvascular decompression for trigeminal neu- ralgia显示文摘 | Barker FG Jannette P J Bissonette DJ | 1996 | N Engl JMed1996，334，17： | 1 |
| 16 | Comparison of the noise sensitivity of nine QRS detection algorithms 显示文摘 | Friensen GM Jannett TC Jadallah MA | 1990 | IEEE Trans on Biomed Eng1990，37，1： | 1 |
| 17 | A compari- son of the noise sensitivity of nine QRS detection algorithms显示文摘 | FRIESEN G M JANNETT T C JADALLAH M A | 1990 | IEEE Transactions on Biomedical Engineering1990，37，8： | 1 |
| 18 | Modeling and closedloop pharmacologic control of the ventrieular rate during induced atrial fibrillation in anesthetized dogs 显示文摘 | Jannett TC Kay GN Croe sley GH | 1990 | Biomed Instrum Technol1990，24，6： | 1 |
| 19 | Comparison of the noise sensitivi ty of nine QRS detection algorithms显示文摘 | FRIENSEN GM JANNETT T C JADALLAH M A | 1990 | IEEE Trans on Biomed Eng1990，37，1： | 1 |
| 20 | Comparison of the noise sensitivity of nine QRS deteetion algorithms 显示文摘 | Friensen GM Jannett TC Jadallah MA | 1990 | IEEE Trans Biomed Eng1990，37，1： | 1 |
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