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	题名	作者	年代	出处	被引量
1	Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma.	Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters	2009	World Journal of Gastroenterology2009，15，28：	11
2	Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy:focal cortical dysplasia and glioneuronal tumors显示文摘	Aronica E Gorter JA Jansen GH	2003	Neuroscience2003，118，：	1
3	Immunohisto chemical characterization of mossy fibre sprouting in the hip pocampus of patients with pharmaco - resistant temporal lobe epilepsy显示文摘	Oestreicher AB Jansen GH	2000	Brain2000，123，：	1
4	Temporoal lobe epilepsy: the various MR appearances of histologically proven mesial temporal selerosis显示文摘	Meiners LC van Gils A Jansen GH	1994	AJNR1994，15，：	1
5	A grading system for hi- ppoeampal sclerosis based on the degree of hippocampal mossy fiber sprouting显示文摘	Proper EA Jansen GH Van Veelen CW	2001	Acta Neuropathol2001，101，：	1
6	Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients 显示文摘	Notenboom RG Hampson DR Jansen GH	2006	Brain2006，129，1：	1
7	Temporal lobe epilepsy: the various MR appearances of histologically proven mesial temporal sclerosis 显示文摘	Meiners LC van Gils A Jansen GH et ol	1994	Am J Neuroradiol1994，15，8：	1
8	Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy:focal cortical dysplasia and glioneuronal tumors显示文摘	ARONICA E GORTER JA JANSEN GH	2003	Neuroscience2003，118，：	1
9	Immunoadsorption (IAS) as a rescue therapy in SLE:considerations on safety and efficacy显示文摘	Stummvoll GH Aringer M Jansen M	2004	Wien Klin Wochenschr2004，116，2122：	1
10	A grading system for hippocampal sclerosis based on the degree of hippocampal mossy fiber sprouting显示文摘	Proper EA Jansen GH van Veelen CW	2001	Acta Neuropathol(Berl)2001，101，4：	1
11	Immunohistoehemieal characterization of mossy fibre sprouting in the hippoeampus of patients with pharrnaeo-resistant temporal lobe epilepsy 显示文摘	Proper EA Oestreieher AB Jansen GH	2000	Brain2000，123，1：	1
12	Expression and celuar distribution of mulfidrug transporter proteins in two major causes of medically intractable epilepsy:focal cortical dysplasia and glioneuronal tumors 显示文摘	Aronica E Goner JA Jansen GH	2003	Neuroscience2003，118，2：	1
13	A gradingsystem for hippocampus sclerosis based on the degree of hippocampal mossy fiber sprouting 显示文摘	Proper EA Jansen GH van Veelen CW	2001	Acta Neuropathol (Berl)2001，101，：	1
14	Immunoadsorption (IAS) as a rescue therapy in SLE:considerations on safety and efficacy显示文摘	Stummvoll GH Aringer M Jansen M	2004	Wien Klin Wochenschr2004，116，2122：	1
15	Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glineuronal tumors显示文摘	Aronica E Gorter JA Jansen GH	2003	Neuroscience2003，118，2：	1
16	Immunohistochemical characterization of mossy fiber sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy显示文摘	Proper EA Oestreicher AB Jansen GH	2000	Brain2000，123，1：	1
17	Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy显示文摘	Proper EA Oestreicher AB Jansen GH	2000	Brain2000，123，1：	1
18	'Gangliocytomas' of the pituitary: a heterogeneous group of lesions with differing histogenesis 显示文摘	Geddes JF Jansen GH Robinson SF	2000	Am J Surg Pathol2000，24，4：	1
19	Expression and cellular distribution of multidrug transporter proteins in two ma jor causes of medically intractable epilepsy: focal cortical dys plasia and glioneuronal tumors显示文摘	Aronica E Gorter JA Jansen GH	2003	Neuroscience2003，11，8：	1
20	Immunoadsorption (IAS) as a rescue therapy in SLE : considerations on safety and efficacy显示文摘	Stummvoll GH Aringer M Jansen M	2004	Wien Klin Wochensehr2004，116，2122：	1

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