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257篇 您的检索式：作者名="Jansen V"

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	题名	作者	年代	出处	被引量
1	miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。	van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊	2018	神经损伤与功能重建2018，13，12：	3
2	Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘	Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al	2010	2010 (9746)2010，，9746：	2
3	Biofilm formation and cell-to-cell signaling in Gram-negative bacteria isolated from a food processing environment显示文摘	Houdt R V Aertsen A Jansen A	2004	Journal of Applied Microbiology2004，，：	1
4	Localization of inducible nitric oxide synthase in acute renal allograft rejection in the rat显示文摘	Smith J Jansen A	1994	Transplantation1994，58，：	1
5	Diagnosis of patent foramen ovale by transesophageal echocardiography and correlation with autopsy findings显示文摘	Schneider B Zienkiewicz T Jansen V	1996	Am J Cardiol1996，77，14：	1
6	Development and evaluation of the piecewise Prony method for evoked potential analysis显示文摘	Garoosi V Jansen B H	2000	IEEE Transactions on Biomedical Engineering2000，47，12：	1
7	Psychological contract breach and job attitudes:A meta-analysis of age as a moderator 显示文摘	Bal P M De Lange A H Jansen P G W Der Velde M E G V	2008	Journal of Vocational Behavior2008，72，1：	1
8	MC-LMAC:a multi-channel MAC protocol for wireIess sensor networks显示文摘	Incel O D Hoesel L V Jansen P	2011	Ad Hoe Networks2011，9，1：	1
9	Modelling the influence of human behaviour on the spread of infectious diseases: a review显示文摘	FUNK S SALATH6 M JANSEN V A A	2010	J R S oc Interface2010，7，50：	1
10	Electroencephalogram and visual e- voked potential generation in a mathematical model of coupled cortical columns 显示文摘	JANSEN B H RIT V G	1995	Biol Cybern1995，73，4：	1
11	Silicon nitride nanosieve membrane 显示文摘	TONG H D JANSEN H V GADGIL V J	2004	Nano Letters2004，4，：	1
12	Diagnosis of patent foramen ovale by transesophngeal echocardiography and correlation with autopsy findings显示文摘	Schneider B Zienkiewicz T Jansen V	1996	Am J Cardiol1996，77，14：	1
13	New acid catalyst comprising heteropoly acid on a mesoporous molecular sieve MCM-41显示文摘	Kozheunikov I V Sinnema A Jansen R J	1995	Catal Lett1995，30，2：	1
14	Managing potential and realized absorptive capacity:how do organizational antecedents matter?显示文摘	JANSEN J J P BOSCH F A J V VOLBERDA H W	2005	Academy of Management Journal2005，48，6：	1
15	Hostderived proteinases and degradation of dentine collagen in situ显示文摘	van Strijp AJ Jansen DC DeGroot J ten Cate JM Everts V	2003	Caries Res2003，37，：	1
16	Electroencephalogram and visual evoked potential generation in a mathematical model of coupled cortical columns显示文摘	Jansen B H Rit V G	1995	Biological Cybernetics1995，73，4：	1
17	Central command neurons of the sympathetic nervous system: basis of the fight-or-flight response 显示文摘	Jansen AS Nguyen XV Karpitskiy V	1995	Science1995，270，：	1
18	Microwave preparation of zeolite Y and ZSM-5 显示文摘	ARAFAT A JANSEN J C EBAID A R BEKKUM H V	1993	Zeolites1993，13，3：	1
19	Advanced plasma processing combined with trench isolation technology for fabrication and fast prototyping of high aspect ratio MEMS in standard silicon wafers显示文摘	SARAJLIC'E de BOER M J JANSEN H V	2004	J Micromech Microeng2004，14，9：	1
20	Effect of cognitive-behavioral ther- apy on neural correlates of fear conditioning in panic disorder 显示文摘	Kircher T Arolt V Jansen A	2013	Biol Psychiatry2013，73，1：	1

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