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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Combing new technologies for determination of phytoplankton community structure in the northern gulf of Mexico显示文摘 | JASON H S LISA C TAMMI L R | 2005 | Journal Plankton2005，41，： | 1 |
| 4 | A Study of an ecnomic production-shipment policy for a single-buyer systerm 显示文摘 | Pan C H Jason Yang J S | 2000 | European Journal of Operational Research2000，121，： | 1 |
| 5 | The evolution of microstructure change and mechanical properties for a nickel silicide based alloy doped with carbon and boron显示文摘 | Jang Ou C J Jason S C Cheng C Y | 2002 | Materials Science and Engineering2002，，： | 1 |
| 6 | A Mathematical Model for Warehouse Design and Product Allocation显示文摘 | Sunderesh S Heragu Jason C S Huang | 2003 | International Journal of Production Research2003，，4： | 1 |
| 7 | Selective determination of amino acids using flow injection analysis coupled with chemiluminescence detection 显示文摘 | JASON W C PAUL S F SIMON W L | 2003 | Anal Chim Acta2003，480，： | 1 |
| 8 | Characterization of growth and osteogenic differentiation of rabbit bone marrow stromal cells显示文摘 | Jason R Brian C David S | 2006 | J Surg Res2006，，： | 1 |
| 9 | Identification and composi- tion of phenolic compounds in the preparation of oolong tea manu, factured by semifermentation and drying processes 显示文摘 | Dou J P Viola S Y L Jason T C T | 2007 | J Aric Food Chem2007，55，： | 1 |
| 10 | Formation and control of box-shaped ultra-shallow junction using laser annealing and pre-amorphization implantation显示文摘 | Kim S D Park C M Jason C S W | 2005 | Solid-State Electronics2005，49，1： | 1 |
| 11 | Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis显示文摘 | Jason S Gold Mithat G?nen Antonio Gutiérrez Javier Martín Broto Xavier García-del-Muro Thomas C Smyrk Robert G Maki Samuel Singer Murray F Brennan Cristina R Antonescu John H Donohue Ronald P DeMatteo | 2009 | Lancet Oncology2009，，11： | 1 |
| 12 | Estimation in gaussian graphical models using tractable subgraphs:a walk sum analysis显示文摘 | Venkat C Jason K Alan S | 2008 | IEEE Transactions on Signal Processing2008，56，5： | 1 |
| 13 | A mathematical model for warehouse design and product allocation显示文摘 | Heragu S S Jason C Huang S | 2003 | International Journal of Production Research2003，4，： | 1 |
| 14 | A model of R&D valuation and the design of research incentives 显示文摘 | Jason Hsu C Eduardo Schwartz S | 2008 | Mathematics and Economics2008，，6： | 1 |
| 15 | The tun- nel source(PNPN) n-MOSFET: A novelHigh per- formance transistor显示文摘 | N Venkatagirish J Ritesh C S W Jason | 2008 | IEEE Transations on Electr on Devices2008，55，4： | 1 |
| 16 | Filter backwash and start-up strategies for enhanced particulate removal显示文摘 | JASON F C PETER H CAROLINE S B | 1996 | Water Research1996，30，10： | 1 |
| 17 | Characterization of water quality factors during intensive raceway production of juvenile Litapenaeus vannamei using limiter discharge and biosecure management tools 显示文摘 | JASON M C TZACHI M S JOE M F | 2005 | Aquacultural Engineering2005，32，： | 1 |
| 18 | Integrin function in T cell homing to lymphoid and non-lymphoid sites:getting there and staying there 显示文摘 | Christopher C DeNucci Jason S | 2009 | Crit Rev Immunol2009，29，2： | 1 |
| 19 | Trust, trustworthiness, and trust propensity, a meta-analysis test of their unique relationships with risk and performance 显示文摘 | Jason A C Brent A S Jeffery A L | 2007 | Journal of Applied Psychology2007，，92： | 1 |
| 20 | A model of R&D valuation and the design of research incentives显示文摘 | Jason Hsu C Eduardo Schwartz S | 2008 | Mathematics and Economics2008，77，6： | 1 |
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