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1篇 您的检索式：作者名="Jason W.K.Goh"

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		题名	作者	年代	出处	被引量
	1	The class A macrophage scavenger receptor type I (SR-AI) recognizes complement iC3b and mediates NF-κB activation显示文摘The macrophage scavenger receptor SR-AI binds to host tissue debris to perform clearance and it binds to bacteria for phagocytosis.In addition,SR-AI modulates macrophage activation through cell signaling.However,investigation of SR-AI signaling on macrophages is complicated due to its promiscuous ligand specificity that overlaps with other macrophage receptors.Therefore,we expressed SR-AI on HEK 293T cells to investigate its ligand binding and signaling.On 293T cells,SR-AI could respond to E.coli DH5α,leading to NF-κB activation and IL-8 production.However,this requires E.coli DH5αto be sensitized by fresh serum that is treated with heat-inactivation or complement C3 depletion.Anti-C3 antibody inhibits the binding of SR-AI to serum-sensitized DH5αand blocks DH5αstimulation of SR-AI signaling.Further analysis showed that SR-AI can directly bind to purified iC3b but not C3 or C3b.By mutagenesis,The SRCR domain of SR-AI was found to be essential in SR-AI binding to serum-sensitized DH5α.These results revealed a novel property of SR-AI as a complement receptor for iC3b-opsonized bacteria that can elicit cell signaling.	Jason W.K.Goh Yen Seah Tan Alister W.Dodds Kenneth B.M.Reid Jinhua Lu	2010	Protein & Cell2010，1，2：	0

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