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| 1 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 2 | Capsule endoscopy capture rate: Has 4 frames-per-second any impact over 2frames-per-second?显示文摘AIM: To compare the current capsule and a new prototype at 2 and 4 frames-per-second, respectively, in terms of clinical and therapeutic impact. METHODS: One hundred patients with an indication for capsule endoscopy were included in the study. All procedures were performed with the new device(SB24). After an exhaustive evaluation of the SB24 videos, they were then converted to 'SB2-like' videos for their evaluation. Findings, frames per finding, and clinical and therapeutic impact derived from video visualization were analyzed. Kappa index for interobserver agreement and χ2 and Student's t tests for qualitative/quantitative variables, respectively, were used. Values of P under 0.05 were considered statistically significant.RESULTS: Eighty-nine out of 100 cases included in the study were ultimately included in the analysis. The SB24 videos detected the anatomical landmarks(Zline and duodenal papilla) and lesions in more patients than the 'SB2-like' videos. On the other hand, the SB24 videos detected more frames per landmark/lesion than the 'SB2-like' videos. However, these differences were not statistically significant(P > 0.05). Both clinical and therapeutic impacts were similar between SB24 and 'SB2-like' videos(K = 0.954). The time spent by readers was significantly higher for SB24 videos visualization(P < 0.05) than for 'SB2-like' videos when all images captured by the capsule were considered. However, these differences become non-significant if we only take into account small bowel images(P > 0.05).CONCLUSION: More frames-per-second detect more landmarks, lesions, and frames per landmark/lesion, but is time consuming and has a very low impact on clinical and therapeutic management. | Ignacio Fernandez-Urien Cristina Carretero Erika Borobio Ana Borda Emilio Estevez Sara Galter Begoa Gonzalez-Suarez Benito Gonzalez Marisol Lujan Jose Luis Martinez Vanessa Martínez Pedro Menchén Javier Navajas Vicente Pons Cesar Prieto Julio Valle | 2014 | World Journal of Gastroenterology2014，20，39： | 2 |
| 3 | Colorectal cancer screening and surveillance in patients with inflammatory bowel disease in 2021显示文摘The detection of dysplasia in patients with inflammatory bowel disease(IBD)continues to be important given the increased risk of colorectal cancer in this population.Therefore,in 2017,we performed a review and update of the recommendations for the management and follow-up of patients with IBD based on the clinical practice guidelines of various scientific societies.The present manuscript focuses on new aspects of the detection,follow-up,and management of dysplasia according to the latest studies and recommendations.While chromoendoscopy with targeted biopsy continues to be the technique of choice for the screening and detection of dysplasia in IBD,the associated difficulties mean that it is now being compared with other techniques(virtual chromoendoscopy),which yield similar results with less technical difficulties.Furthermore,the emergence of new endoscopy techniques that are still being researched but seem promising(e.g.,confocal laser endomicroscopy and full-spectrum endoscopy),together with the development of devices that improve endoscopic visualization(e.g.,Endocuff Vision),lead us to believe that these approaches can revolutionize the screening and follow-up of dysplasia in patients with IBD.Nevertheless,further studies are warranted to define the optimal follow-up strategy in this patient population. | Jose Maria Huguet Luis Ferrer-Barceló Patrícia Suárez Eva Sanchez Jose David Prieto Victor Garcia Javier Sempere | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 4 | αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model显示文摘Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular organisms.Their regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with age.During aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016). | Paloma Martinez-Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo Juan Manuel Lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2020 | Protein & Cell2020，11，3： | 2 |
| 5 | Effect of ripening time and type of rennet (farmhouse rennet from kid or commercial calf) on proteolysis during the ripening of León cow milk cheese显示文摘 | Bernardo Prieto Inmaculada Franco José M. Fresno Josefa González Prieto Ana Bernardo Javier Carballo | 2003 | Food Chemistry2003，，3： | 1 |
| 6 | Melatonin treatment reduces endoplasmic reticulum stress and modulates the unfolded protein response in rabbits with lethal fulminant hepatitis of viral origin显示文摘 | María J. Tu?ón Beatriz San‐Miguel Irene Crespo Almudena Laliena Daniela Vallejo Marcelino álvarez Jesús Prieto Javier González‐Gallego | 2013 | Pineal Res2013，，3： | 1 |
| 7 | Inhibition of matrix metalloproteinase‐9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in H ep G 2 liver cancer cells显示文摘 | Raquel Ordo?ez Sara Carbajo‐Pescador Néstor Prieto‐Dominguez Andrés García‐Palomo Javier González‐Gallego José L. Mauriz | 2014 | J Pineal Res2014，，1： | 1 |
| 8 | An augmented lagrangian interior-point method using directions of negative curvature 显示文摘 | Moguerza Javier M Prieto Francisco J | 2003 | Mathematical Programming2003，95，3： | 1 |
| 9 | Influence of tumor characteristics on the outcome of liver transplantation among patients with liver cirrhosis and hepatocellular carcinoma显示文摘 | J.Ignacio Herrero Bruno Sangro Jorge Quiroga Fernando Pardo Maite Herraiz Javier A. Cienfuegos Jesus Prieto | 2001 | Liver Transplantation2001，，7： | 1 |
| 10 | Influence of tumor characteristics on the outcome of liver transplantation among patients with liver cirrhosis and hepatocellular carcinoma显示文摘 | J.Ignacio Herrero Bruno Sangro Jorge Quiroga Fernando Pardo Maite Herraiz Javier A. Cienfuegos Jesus Prieto | 2001 | Liver Transplantation2001，，7： | 1 |
| 11 | Nonmelanoma skin cancer after liver transplantation. Study of risk factors显示文摘 | J. Ignacio Herrero Agustín Espa?a Jorge Quiroga Bruno Sangro Fernando Pardo Javier Alvárez‐Cienfuegos Jesús Prieto | 2005 | Liver Transpl2005，，9： | 1 |
| 12 | Radioembolization using 90Y-resin microspheres for patients with advanced hepatocellular carcinoma显示文摘 | Bruno Sangro Jose I. Bilbao Jose Boan Antonio Martinez-Cuesta Alberto Benito Javier Rodriguez Angel Panizo Belen Gil Mercedes Inarrairaegui Ignacio Herrero Jorge Quiroga Jesus Prieto | 2006 | International Journal of Radiation Oncology, Biology, Physics2006，，3： | 1 |
| 13 | Transmission of Hepatitis C Virus Infection to Tree Shrews显示文摘 | Zhi-Chun Xie Jose-Ignacio Riezu-Boj Juan-Jose Lasarte Javier Guillen Jie-Han Su Maria-Pilar Civeira Jesus Prieto | 1998 | Virology1998，，2： | 1 |
| 14 | Documento de consenso de la AEEH sobre el tratamiento de la infección por el virus de la hepatitis B (2012)显示文摘 | María Buti Javier García-Samaniego Martín Prieto Manuel Rodríguez José María Sánchez-Tapias Emilio Suárez Rafael Esteban | 2012 | Gastroenterologia y Hepatologia2012，，7： | 1 |
| 15 | Improving face recognition by combination of natural and Gabor faces显示文摘 | Christian Tenllado José Ignacio Gómez Javier Setoain Darío Mora Manuel Prieto | 2010 | Pattern Recognition Letters2010，，11： | 1 |
| 16 | Collaborative learning via social computing显示文摘Educational innovation is a field that has been greatly enriched by using technology in its processes, resulting in a learning model where information comes from numerous sources and collaboration takes place among multiple students. One attractive challenge within educational innovation is the design of collaborative learning activities from the social computing point of view, where collaboration is not limited to student-to-student relationships, but includes student-to-machine interactions. At the same time, there is a great lack of tools that give support to the whole learning process and are not restricted to specific aspects of the educational task. In this paper, we present and evaluate context-aware framework for collaborative learning applications(CAFCLA) as a solution to these problems. CAFCLA is a flexible framework that covers the entire process of developing collaborative learning activities, taking advantage of contextual information and social interactions. Its application in the experimental case study of a collaborative WebQuest within a museum has shown that, among other benefits, the use of social computing improves the learning process, fosters collaboration, enhances relationships, and increases engagement. | Ricardo S.ALONSO Javier PRIETO óscar GARCíA Juan M.CORCHADO | 2019 | Frontiers of Information Technology & Electronic Engineering2019，20，2： | 1 |
| 17 | Experimental thermal behaviour of a power plant rehater显示文摘 | M Manuela Prieto Gonzalez F Javier Fernandez Garcla Ines Suarez Ramon | 2006 | Energy2006，31，5： | 1 |
| 18 | Prognostic factors and prevention of radioembolization‐induced liver disease显示文摘 | Belen Gil‐Alzugaray Ana Chopitea Mercedes I?arrairaegui Jose I. Bilbao Macarena Rodriguez‐Fraile Javier Rodriguez Alberto Benito Inés Dominguez Delia D’Avola Jose I. Herrero Jorge Quiroga Jesus Prieto Bruno Sangro | 2013 | Hepatology2013，，： | 1 |
| 19 | Safety and Efficacy of Granulocyte and Monocyte Adsorption Apheresis in Paediatric Inflammatory Bowel Disease: A Prospective Pilot Study显示文摘 | Javier Martín de Carpi Pere Vilar Gerardo Prieto María Dolores García Novo Carmen Ribes Vicente Varea | 2008 | Journal of Pediatric Gastroenterology and Nutrition2008，，4： | 1 |
| 20 | Early tacrolimus exposure does not impact long-term outcomes after liver transplantation显示文摘BACKGROUND Tacrolimus trough levels(TTL)during the first weeks after liver transplantation(LT)have been related with long-term renal function and hepatocellular carcinoma recurrence.Nevertheless,the significance of trough levels of tacrolimus during the early post-transplant period for the long-term outcome is under debate AIM To evaluate the effect of TTL during the first month on the long-term outcomes after LT.METHODS One hundred fifty-five LT recipients treated de novo with once-daily tacrolimus were retrospectively studied.Patients with repeated LT or combined transplantation were excluded as well as those who presented renal dysfunction prior to transplantation and/or those who needed induction therapy.Patients were classified into 2 groups according to their mean TTL within the first month after transplantation:≤10(n=98)and>10 ng/mL(n=57).Multivariate analyses were performed to assess risk factors for patient mortality.RESULTS Mean levels within the first month post-transplant were 7.4±1.7 and 12.6±2.2 ng/mL in the≤10 and>10 groups,respectively.Donor age was higher in the high TTL group 62.9±16.8 years vs 45.7±17.5 years(P=0.002)whilst mycophenolate-mofetil was more frequently used in the low TTL group 32.7%vs 15.8%(P=0.02).Recipient features were generally similar across groups.After a median follow-up of 52.8 mo(range 2.8-81.1),no significant differences were observed in:Mean estimated glomerular filtration rate(P=0.69),hepatocellular carcinoma recurrence(P=0.44),de novo tumors(P=0.77),new-onset diabetes(P=0.13),or biopsy-proven acute rejection rate(12.2%and 8.8%,respectively;P=0.50).Eighteen patients died during the follow-up and were evenly distributed across groups(P=0.83).Five-year patient survival was 90.5%and 84.9%,respectively(P=0.44),while 5-year graft survival was 88.2%and 80.8%,respectively(P=0.42).Early TTL was not an independent factor for patient mortality in multivariate analyses.CONCLUSION Differences in tacrolimus levels restricted to the first month after transplant did not result in significant differences in long-term outcomes of LT recipients. | Mikel Gastaca Patricia Ruiz Javier Bustamante Lorea Martinez-Indart Alberto Ventoso JoséRamón Fernandez Ibone Palomares Mikel Prieto Milagros Testillano Patricia Salvador Maria Senosiain Maria Jesus Suárez Andres Valdivieso | 2021 | World Journal of Hepatology2021，13，3： | 0 |
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