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| 1 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 2 | Stretch-induced myoblast proliferation is dependent on the COX2 pathway 显示文摘 | Jeffrey SO Thomas JB Grace KP | 2005 | Exp Cell Res2005，310，2： | 1 |
| 3 | Control of Apoptosis during Angiogenesis by survivin Expression in Endothelial Cells显示文摘 | Daniel SO Jeffrey SS Colette A | 2000 | Am J Pathol2000，156，2： | 1 |
| 4 | Neurological recovery after cranioplasty 显示文摘 | David HS Jeffrey SO Judith AM | 1994 | Neurosurgery1994，34，4： | 1 |
| 5 | Control of Apoptosis during Angiognesis by surviving expression in endothelial cell 显示文摘 | Daniel SO Jeffrey SS Colette A | 2000 | Am J Pathol2000，156，2： | 1 |
| 6 | Control of apoptosis during angiogenesis by survivin expression in endothelial cells显示文摘 | Daniel SO Jeffrey SS Colette A | 2000 | Am J Pathol2000，156，2： | 1 |
| 7 | Expression of osteogenic protein-1 mRNA in cultured kidney cells 显示文摘 | Allison MK Jeffrey IK Merle SO | 1999 | J Cell Physiol1999，181，3： | 1 |
| 8 | Current landscape and potential future applications of artificial intelligence in medical physics and radiotherapy显示文摘Artificial intelligence(AI)has seen tremendous growth over the past decade and stands to disrupts the medical industry.In medicine,this has been applied in medical imaging and other digitised medical disciplines,but in more traditional fields like medical physics,the adoption of AI is still at an early stage.Though AI is anticipated to be better than human in certain tasks,with the rapid growth of AI,there is increasing concerns for its usage.The focus of this paper is on the current landscape and potential future applications of artificial intelligence in medical physics and radiotherapy.Topics on AI for image acquisition,image segmentation,treatment delivery,quality assurance and outcome prediction will be explored as well as the interaction between human and AI.This will give insights into how we should approach and use the technology for enhancing the quality of clinical practice. | Wing-Yan Ip Fu-Ki Yeung Shang-Peng Felix Yung Hong-Cheung Jeffrey Yu Tsz-Him So Varut Vardhanabhuti | 2021 | Artificial Intelligence in Medical Imaging2021，2，2： | 0 |
| 9 | Prostate cancer:a presentation of climcopathologic prognosticators among Filipino and American men at radical prostatectomy显示文摘Lower incidence and mortality rates from prostate cancer(PCa)have been shown in Asian men in general compared to Westerners.This is the first study detailing the clinicopathologic features of resected prostate cancer in Filipino men living in the Philippines(PH)_This study investigated the supposed“lower risk”Filipino and“higher risk”American PCa patients from the PH and the United States of America(USA),respectively.We examined 348(176 from PH,172 from USA)radical prostatectomy cases.The clinicopathologic features of both groups(age at time of diagnosis,preoperative prostate-specific antigen[pre-op PSA]level,Gleason score[GS],Grade groups[GG],margin involvement,extra prostatic extension[EPE],seminal vesicle invasion[SVI],and regional lymph node[RLN]metastasis)were compared.Six of seven prognosticators examined were more strongly associated with Filipinos than with Americans.Filipinos were older at diagnosis(PH:64.32±6.56 years vs USA:58.98±8.08 years)and had higher pre-op PSA levels(PH:21.39±46.40 ng ml^(-1) vs USA:7.63±9.19 ng ml^(-1)).Filipino men had more advanced grade,GG 2 with minor pattern 5(PH:6.2%vs USA:2.9%)and GG 5(PH:14.8%vs USA:3.5%).Likewise,other adverse pathological features in margin positivity(PH:52.3%vs USA:23.8%),focal EPE(PH:14.2% vs USA:2.3%),and SVI(PH:17.1%vs USA:5.8%)were more commonly observed in Filipinos.This study reveals the prognostic disadvantage of Filipinos versus Americans and highlights an important difference of Filipinos from other studied Asian ethnicities that have repeatedly been shown to have lower-risk PCa.This study,the first on Filipino PCa patients with RP,suggests the need to modify Western-based risk stratification when employed in other countries like the PH. | Mayen T Grageda Bonnie Choy Gladell P Paner Jeffrey S So | 2021 | Asian Journal of Andrology2021，23，5： | 0 |
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