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| 1 | 三苯双脒、青蒿琥酯、蒿甲醚和吡喹酮单剂、多剂或联合用药治疗大鼠华支睾吸虫感染的实验研究显示文摘目的观察三苯双脒、青蒿琥酯、蒿甲醚、或吡喹酮单剂、多剂给药,及其伍用治疗感染华支睾吸虫大鼠的疗效。方法147只SD大鼠各感染50个华支睾吸虫囊蚴,于感染后42~44d分组治疗。各药物采用灌胃给药。①60只感染大鼠随机分为11组(每组4~5只),分别为三苯双脒150mg/kg(顿服)、75mg/(kg·d)×2d、50mg/(kg·d)×3d和25mg/kg(tid)×2d组;吡喹酮150mg/kg(顿服)、75mg/(kg·d)×2d和25mg/kg(tid)×2d;青蒿琥酯或蒿甲醚75mg/kg(顿服)和37.5mg/(kg·d)×2d组。②另87只感染大鼠随机分为15组(每组4~6只),用青蒿琥酯或蒿甲醚(30mg/kg)分别与吡喹酮(150mg/kg)、三苯双脒(50mg/kg和75mg/kg)伍用组;三苯双脒(50mg/kg)与吡喹酮(150mg/kg)伍用组;三苯双脒(75mg/kg)与吡喹酮(187.5mg/kg)伍用组,及各药的单用组。并设同批感染未治疗对照组。受治鼠于治疗后2周剖杀,收集胆管和肝组织内的残留华支睾吸虫,计算各组的平均虫数和减虫率,用非参数统计方法(Mann-Whitney秩和检验)对相应组间的平均虫数进行分析。结果感染华支睾吸虫的大鼠口服单剂三苯双脒或吡喹酮(150mg/kg)的减虫率分别为57.2%和63.8%。三苯双脒各小剂量多次给药组的减虫率稍高,达77.1%~79.4%,而吡喹酮小剂量多次给药组的减虫率则为50.6%~54.2%。但两种药物各组间的平均虫数的差异无统计学意义。青蒿琥酯和蒿甲醚各单剂给药组与小剂量多次给药组的减虫率均较高,分别为90.4%~98.5%和100%。三苯双脒小剂量(50或75mg/kg)与吡喹酮(150mg/kg或187.5mg/kg)伍用治疗,减虫率为74.9%~100%,高于其各单药组的减虫率(26.9%~79.6%)。青蒿琥酯或蒿甲醚小剂量(30mg/kg)与吡喹酮(150mg/kg)或三苯双脒(50或75mg/kg)伍用治疗,减虫率为74.9%~97.9%,亦高于其各药组的减虫率(24.8%~79.6%)。结论青蒿琥酯、蒿甲醚、吡喹酮和三苯双脒均为有效的抗华支睾吸虫药物,各药物小剂量伍用具有增效作用。 | 肖树华 薛剑 Marcel TANNER 张永年 Jennifer KEISER Jug UTZINGER 强慧琴 刘晓云 | 2008 | 中国寄生虫学与寄生虫病杂志2008，26，5： | 10 |
| 2 | Controlling schistosomiasis with praziquantel:How much longer without a viable alternative?显示文摘The current approach of morbidity control of schistosomiasis,a helminth disease of poverty with considerable public health and socioeconomic impact,is based on preventive chemotherapy with praziquantel.There is a pressing need for new drugs against this disease whose control entirely depends on this single drug that has been widely used over the past 40 years.We argue that a broader anthelminthic approach supplementing praziquantel with new antischistosomals targeting different parasite development stages would not only increase efficacy but also reduce the risk for drug resistance.Repositioning drugs already approved for other diseases provides a shortcut to clinical trials,as it is expected that such drugs rapidly pass the regulatory authorities.The antischistosomal properties of antimalarial drugs(e.g.,semisynthetic artemisinins,synthetic trioxolanes,trioxaquines and mefloquine)and of drugs being developed or registered for other purposes(e.g.,moxidectin and miltefosin),administered alone or in combination with praziquantel,have been tested in the laboratory and clinical trials.Another avenue to follow is the continued search for new antischistosomal properties in plants.Here,we summarise recent progress made in schistosomiasis chemotherapy,placing particular emphasis on repositioning of existing drugs against schistosomiasis. | Robert Bergquist Jürg Utzinger Jennifer Keiser | 2017 | Infectious Diseases of Poverty2017，6，1： | 7 |
| 3 | The Drugs We Have and the Drugs We Need Against Major Helminth Infections显示文摘 | Jennifer Keiser Jürg Utzinger | 2010 | Advances in Parasitology2010，，： | 2 |
| 4 | Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk显示文摘 | Peter Steinmann Jennifer Keiser Robert Bos Marcel Tanner Jürg Utzinger | 2006 | The Lancet Infectious Diseases2006，，7： | 2 |
| 5 | Global burden of human food-borne trematodiasis: a systematic review and meta-analysis显示文摘 | Thomas Fürst Jennifer Keiser Jürg Utzinger | 2012 | The Lancet Infectious Diseases2012，，3： | 1 |
| 6 | Fasciola hepatica : Tegumental alterations in adult flukes following in vitro and in vivo administration of artesunate and artemether显示文摘 | Jennifer Keiser Gianni Morson | 2007 | Experimental Parasitology2007，，2： | 1 |
| 7 | Fasciola hepatica : Tegumental alterations in adult flukes following in vitro and in vivo administration of artesunate and artemether显示文摘 | Jennifer Keiser Gianni Morson | 2007 | Experimental Parasitology2007，，2： | 1 |
| 8 | Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk显示文摘 | Peter Steinmann Jennifer Keiser Robert Bos Marcel Tanner Jürg Utzinger | | The Lancet Infectious Diseases0，，： | 1 |
| 9 | Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk显示文摘 | Peter Steinmann Jennifer Keiser Robert Bos Marcel Tanner Jürg Utzinger | 2006 | The Lancet Infectious Diseases2006，，7： | 1 |
| 10 | From innovation to application: Social–ecological context, diagnostics, drugs and integrated control of schistosomiasis显示文摘 | Jürg Utzinger Eliézer K. N’Goran Conor R. Caffrey Jennifer Keiser | 2010 | Acta Tropica2010，，： | 1 |
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