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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | Impact of enclosure management on soil properties and microbial biomass in a restored semi-arid rangeland, Kenya显示文摘Rangeland degradation is a serious problem throughout sub-Saharan Africa and its restoration is a challenge for the management of arid and semi-arid areas. In Lake Baringo Basin of Kenya, communities and individual farmers are restoring indigenous vegetation inside enclosures in an effort to combat severe land degradation and address their livelihood problems. This study evaluated the impact of enclosure management on soil properties and microbial biomass, being key indicators of soil ecosystem health. Six reseeded communal enclosures using soil embankments as water-harvesting structures and strictly regulated access were selected, varying in age from 13 to 23 years. In six private enclosures, ranging from 3 to 17 years in age, individual farmers emulated the communal enclosure strategy and restored areas for their exclusive use. Significant decreases in bulk density, and increases in the soil organic carbon, total nitrogen and microbial biomass contents and stocks were found in the enclosures as compared with the degraded open rangeland. In the private enclosures, the impact of rehabilitation on the soil quality was variable, and soil quality was in general lower than that obtained under communal management. The significant increase of absolute stocks of carbon, nitrogen and microbial biomass compared to the degraded open rangeland indicates the potential for the restoration of soil quality through range rehabilitation. Over-sowing with indigenous legume fodder species could improve total nitrogen content in the soil and nutritional value of the pastures as well. | Stephen M MUREITHI Ann VERDOODT Charles KK GACHENE Jesse T NJOKA Vivian O WASONGA Stefaan De NEVE Elizabeth MEYERHOFF Eric Van RANST | 2014 | Journal of Arid Land2014，6，5： | 3 |
| 3 | Prognostic impact of the Bismuth-Corlette classification:Higher rates of local unresectability in stageⅢb hilar cholangiocarcinoma显示文摘Background:The Bismuth-Corlette(BC)classification is used to categorize hilar cholangiocarcinoma by proximal extension along the biliary tree.As the right hepatic artery crosses just behind the left bile duct,we hypothesized that BCⅢb tumors would have a higher likelihood of local unresectability due to involvement of the contralateral artery.Methods:A retrospective review of a prospectively maintained database identified patients with hilar cholangiocarcinoma taken to the operating room for intended curative resection between April 2008 and September 2016.Cases were assigned BC stages based on preoperative imaging.Results:Sixty-eight patients were included in the study.All underwent staging laparoscopy after which 16 cases were aborted for metastatic disease.Of the remaining 52 cases,14 cases were explored and aborted for locally advanced disease.Thirty-eight underwent attempt at curative resection.After exclud-ing cases aborted for metastatic disease,the chance of proceeding with resection was 55.6%for BCⅢb staged lesions compared to 80.0%of BCⅢa lesions and to 82.4%for BCⅠ-Ⅲa staged lesions(P<0.05).About 44.4%of BCⅢb lesions were aborted for locally advanced disease versus 17.6%of remaining BC stages.Conclusions:When hilar cholangiocarcinoma is preoperatively staged as BCⅢb,surgeons should antici-pate higher rates of locally unresectable disease,likely involving the right hepatic artery. | Michael J Passeri Maria R Baimas-George Jesse K Sulzer David A Iannitti John B Martinie Erin H Baker Lee M Ocuin Dionisios Vrochides | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 3 |
| 4 | Hepatocellular carcinoma after Iocoregional therapy:Magnetic resonance imaging findings in falsely negative exams显示文摘AIM:To elucidate causes for false negative magnetic resonance imaging(MRI)exams by identifying imaging characteristics that predict viable hepatocellular carcinoma(HCC)in lesions previously treated with locoregional therapy when obvious findings of recurrence are absent.METHODS:This retrospective institutional review board-approved and Health Insurance Portability and Accountability Act-compliant study included patients who underwent liver transplantation at our center between 1/1/2000 and 12/31/2012 after being treated for HCC with locoregional therapy.All selected patients had a contrast-enhanced MRI after locoregional therapy within 90 d of transplant that was prospectively interpreted as without evidence of residual or recurrenttumor.Retrospectively,2 radiologists,blinded to clinica and pathological data,independently reviewed the pre transplant MRIs for 7 imaging features.Liver explan histopathology provided the reference standard,with clinically significant tumor defined as viable tumor≥1.0cm in maximum dimension.Fisher’s exact test was firs performed to identify significant imaging features.RESULTS:Inclusion criteria selected for 42 patients with 65 treated lesions.Fourteen of 42 patients(33%and 16 of 65 treated lesions(25%)had clinically significant viable tumor on explant histology.None o the 7 imaging findings examined could reliably and reproducibly determine which treated lesion had viable tumor when the exam had been prospectively read as without evidence of viable HCC.CONCLUSION:After locoregional therapy some treated lesions that do not demonstrate any MRI evidence o HCC will contain viable tumor.As such even patients with a negative MRI following treatment should receive regular short-term imaging surveillance because some have occult viable tumor.The possibility of occult tumo should be a consideration when contemplating any action which might delay liver transplant. | David Becker-Weidman Jesse M Civan Sandeep P Deshmukh Christopher G Roth Steven K Herrine Laurence Parker Donald G Mitchell | 2016 | World Journal of Hepatology2016，8，16： | 2 |
| 5 | Magnetic resonance imaging of cystic adnexal lesions during pregnancy 显示文摘 | Oto A Ernst R Jesse M K | 2008 | Curr Probl Diagn Radiol2008，37，4： | 1 |
| 6 | Effect of eperythrozoonosis on sow productivity显示文摘 | Zinn G M Jesse G W Dobson A W | 1983 | J Am Vet Med Assoe1983，182，： | 1 |
| 7 | Executive Compensation at Fannie Mae: A Case Study of Perverse Incentives, Nonperformance Pay, and Camouflage 显示文摘 | Lucian A Bebchuk Jesse M Fried | 2005 | Journal of Corporation Law2005，30，： | 1 |
| 8 | Epimerisation of menthol stereoisomers: Kinetic studies of the heterogeneously catalysed menthol production显示文摘 | Etzold B Jess A Nobis M | 2009 | Catalysis Today2009，140，12： | 1 |
| 9 | Expression of prolife- rative biomarkers in anal intraepithelial neoplasia of HIV- positive men显示文摘 | Kreuter A Jesse M Potthoff A | 2010 | J Am Acad Dermatol2010，63，3： | 1 |
| 10 | The Role of Human Capitalin Economic Development Evidence from Aggregate CrossCountry Data显示文摘 | Jess Benhabib Mark M Spiegel | 1994 | Journal of Monetary Economics1994，34，： | 1 |
| 11 | Sheep rumen metabolic development in response to age and dietary treatments显示文摘 | Lane M A Baldwin R L Jesse B W | 2000 | J Anim Sci2000，78，： | 1 |
| 12 | The Role of Human Capital in Economic Development: Exidence from Aggregate Cross - country Data 显示文摘 | Benhabib Jess Spiegel M | 1994 | Journal of Monetary Economics1994，，34： | 1 |
| 13 | Kinetic study of Chinese biomass slow phyrolysis comparison of different kinetic model显示文摘 | Hu S Jess A Xu M | | 0，，17： | 1 |
| 14 | Effect of volatile fatty acid infusion on development of neonatal sheep rumen epithelium显示文摘 | Lane M A Jesse B W | 1997 | J Dairy Sci1997，80，： | 1 |
| 15 | H4stogenesis of giant cell tumors 显示文摘 | Wuelling M Engels C Jesse N | 2002 | Pathologe2002，23，5： | 1 |
| 16 | Open market repurchases: signaling or managerial opportunism? 显示文摘 | Jesse M Fried | 2001 | Theoretical Inquiries in Law2001，2，2： | 1 |
| 17 | Metal - organic frameworks: A new class of porous materials 显示文摘 | Jesse L C Rowsell Omar M Y | 2004 | Microporous and Mesoporous Materials2004，73，12： | 1 |
| 18 | Natural gas exergy recovery powering distributed hydrogen production 显示文摘 | JESSE D MADDALONI ANEREW M | 2007 | Hydrogen Energy2007，32，5： | 1 |
| 19 | High-performance textile-reinforced concrete显示文摘 | Curbach M Jesse F | 1999 | Structural Engineering International1999，9，4： | 1 |
| 20 | Two models of endothelial dysfunction:the importance of intrinsic cardioprotective properties of the coronary-endothelium 显示文摘 | THORSTEN M LEUCKER GE ZHI-DONG JESSE PRO- CKNOW | 2013 | Arterioscler Thromb Vasc Biol2013，33，5： | 1 |
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