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| 1 | A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis显示文摘 | Shuying Shen Xiaocan Guo Huan Yan Yi Lu Xinyan Ji Li Li Tingbo Liang Dawang Zhou Xin-Hua Feng Jonathan C Zhao Jindan Yu Xing-Guo Gong Lei Zhang Bin Zhao | 2015 | Cell Research2015，25，9： | 10 |
| 2 | EZH2, an epigenetic driver of prostate cancer显示文摘The histone methyltransferase EZH2 has been in the limelight of the fi eld of cancer epigenetics for a decade now since it was fi rst discovered to exhibit an elevated expression in metastatic prostate cancer.It persists to attract much scientifi c attention due to its important role in the process of cancer development and its potential of being an effective therapeutic target.Thus here we review the dysregulation of EZH2 in prostate cancer,its function,upstream regulators,downstream effectors,and current status of EZH2-targeting approaches.This review there-fore provides a comprehensive overview of EZH2 in the context of prostate cancer. | Yeqing Angela Yang Jindan Yu | 2013 | Protein & Cell2013，4，5： | 9 |
| 3 | Current perspectives on FOXA1 regulation of androgen receptor signaling and prostate cancer显示文摘FOXA1(also known as hepatocyte nuclear factor 3a,or HNF-3a)is a protein of the FKHD family transcription factors.FOXA1 has been termed as a pioneer transcription factor due to its unique ability of chromatin remodeling in which the chromatin can be decompacted to allow genomic access by nuclear hormone receptors,including androgen receptor(AR)and estrogen receptor(ER).In this review,we discuss our current understanding of FOXA1 regulation of prostatic and non-prostatic AR-chromatin targeting.We present an updated model wherein FOXA1:AR equilibrium in the nuclei defines prostatic AR binding profile,which is perturbed in prostate cancer with FOXA1 and/or AR de-regulation.Finally,we discuss recent efforts in exploring new horizons of AR-independent functions of FOXA1 in prostate cancer and interesting directions to pursue in future studies. | Yeqing Angela Yang Jindan Yu | 2015 | Genes & Diseases2015，2，2： | 5 |
| 4 | Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression显示文摘Dear Editor,F0XA1,a forkhead(FKHD)family transcription factor,is highly expressed in the epithelium of endoderm-derived organs, including the prostate gland.1 Transgenic mouse studies have shown that F0XA1 expression is required for prostate epithelial cell differentiation and ductal morphogenesis during development and for the maintenance of this differentiated epithelial phenotype in the adult. Mechanistically, F0XA1 binds FKHD motifs in the DNA to open chromatin and in crease local accessibility. | Bohan Xu Bing Song Xiaodong Lu Jung Kim Ming Hu Jonathan C.Zhao Jindan Yu | 2019 | Cell Research2019，29，9： | 4 |
| 5 | Transcriptional repression by androgen receptor: roles in castration-resistant prostate cancer显示文摘Androgen receptor (AR), a hormonal transcription factor, plays important roles during prostate cancer progression and is a key target for therapeutic interventions. While androgen-deprivation therapies are initially successful in regressing prostate tumors, the disease ultimately comes back as castration-resistant prostate cancer (CRPC) or at the late stage as neuroendocrine prostate cancer (NEPC). CRPC remains largely dependent on hyperactive AR signaling in the milieu of low androgen, while NEPC is negative of AR expression but positive of many AR-repressed genes. Recent technological advances in genome-wide analysis of transcription factor binding sites have revealed an unprecedented set of AR target genes. In addition to its well-known function in activating gene expression, AR is increasingly known to also act as a transcriptional repressor. Here, we review the molecular mechanisms by which AR represses gene expression. We also summarize AR-repressed genes that are aberrantly upregulated in CRPC and NEPC and represent promising targets for therapeutic intervention. | Galina Gritsina Wei-Qiang Gao Jindan Yu | 2019 | Asian Journal of Andrology2019，21，3： | 4 |
| 6 | Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer显示文摘 | J. Chad Brenner Bushra Ateeq Yong Li Anastasia K. Yocum Qi Cao Irfan A. Asangani Sonam Patel Xiaoju Wang Hallie Liang Jindan Yu Nallasivam Palanisamy Javed Siddiqui Wei Yan Xuhong Cao Rohit Mehra Aaron Sabolch Venkatesha Basrur Robert J. Lonigro Jun Yang | 2011 | Cancer Cell2011，，5： | 1 |
| 7 | The neuronal repellentSLIT2 is a target for repression by EZH2 in prostate cancer显示文摘 | Jindan Yu Qi Cao Jianjun Yu | 2010 | Oncogene2010，29，39： | 1 |
| 8 | Cancer cell migration: when red light switched to green显示文摘 | Seth J Corey Jindan Yu | 2011 | Asian Journal of Andrology2011，13，2： | 1 |
| 9 | Mitochondrial 12S rRNA variants in 1642 Han Chinese pediatric subjects with aminoglycoside-induced and nonsyndromic hearing loss显示文摘 | Jianxin Lu Zhiyuan Li Yi Zhu Aifen Yang Ronghua Li Jing Zheng Qin Cai Guanghua Peng Wuwei Zheng Xiaowen Tang Bobei Chen Jianfu Chen Zhisu Liao Li Yang Yongyan Li Junyan You Yu Ding Hong Yu Jindan Wang Dongmei Sun Jianyue Zhao Ling Xue Jiying Wang Min-Xin | 2010 | Mitochondrion2010，，4： | 1 |
| 10 | Feature selection and molecular classification of canver using genetic program- ming显示文摘 | Yu Jianjun Yu Jindan Almal AA | 2007 | Neoplasia2007，9，： | 1 |
| 11 | Effect of water activity on stress tolerance and biocontrol activity in antagonistic yeast Rhodosporidium paludigenum显示文摘 | Yifei Wang Peng Wang Jindan Xia Ting Yu Binggan Lou Jun Wang Xiao Dong Zheng | 2010 | International Journal of Food Microbiology2010，，3： | 1 |
| 12 | A combination of marine yeast and food additive enhances preventive effects on postharvest decay of jujubes ( Zizyphus jujuba )显示文摘 | Yifei Wang Fei Tang Jindan Xia Ting Yu Jun Wang Remila Azhati Xiao Dong Zheng | 2010 | Food Chemistry2010，，3： | 1 |
| 13 | Biocontrol of postharvest gray mold of cherry tomatoes with the marine yeast Rhodosporidium paludigenum 显示文摘 | Wang Yifei Yu Ting Xia Jindan | 2010 | Biological Con- trol2010，53，2： | 1 |
| 14 | Repression of E-cadherin by the polycomb group protein EZH2 in cancer显示文摘 | QI CAO JINDAN YU SARAVANA M | 2008 | Oneogcne2008，27，58： | 1 |
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