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| 1 | A bioactive injectable self-healing anti-inflammatory hydrogel with ultralong extracellular vesicles release synergistically enhances motor functional recovery of spinal cord injury显示文摘The repair and motor functional recovery after spinal cord injury(SCI)remains a worldwide challenge.The inflammatory microenvironment is one of main obstacles on inhibiting the recovery of SCI.Using mesenchymal stem cells(MSCs)derived extracellular vesicles to replace MSCs transplantation and mimic cell paracrine secretions provides a potential strategy for microenvironment regulation.However,the effective preservation and controlled release of extracellular vesicles in the injured spinal cord tissue are still not satisfied.Herein,we fabricated an injectable adhesive anti-inflammatory F127-polycitrate-polyethyleneimine hydrogel(FE)with sustainable and long term extracellular vesicle release(FE@EVs)for improving motor functional recovery after SCI.The orthotopic injection of FE@EVs hydrogel could encapsulate extracellular vesicles on the injured spinal cord,thereby synergistically induce efficient integrated regulation through suppressing fibrotic scar formation,reducing inflammatory reaction,promoting remyelination and axonal regeneration.This study showed that combining extracellular vesicles into bioactive multifunctional hydrogel should have great potential in achieving satisfactory locomotor recovery of central nervous system diseases. | Chenggui Wang Min Wang Kaishun Xia Jingkai Wang Feng Cheng Kesi Shi Liwei Ying Chao Yu Haibin Xu Shining Xiao Chengzhen Liang Fangcai Li Bo Lei Qixin Chen | 2021 | Bioactive Materials2021，6，8： | 9 |
| 2 | Configuration analysis of a chain-type reconfigurable modular robot inspired by normal alkane显示文摘Normal alkane is an unbranched alkane whose structural formula is H–CH2–CH2–…–CH2–…–CH2–H,which can be regarded as a reconfigurable chain-type structure composed of–CH2–modules.Inspired by normal alkane,a normal-alkane-like reconfigurable modular robot (NAR) is proposed.The module consists of two differential gear trains mounted orthogonally.Each differential gear train contains two input degrees of freedom and two output degrees of freedom.Due to the genderless interface design,multiple modules can be assembled into chain-type configuration.With the genderless interfaces and flexible degrees of freedom,NAR can be reconfigured into different dimensions of spatial configuration.The bond matrix is used to describe the configuration,which represents the bond attitude of the adjacent connected modules.In addition,full interconnected geometric feature (FIGF) algorithm is proposed for non-isomorphic configuration enumeration and judgment.The configurations with three modules are simulated and the results verify the feasibility of the algorithm.Finally,a prototype with three modules is fabricated and the configuration motion sequence is demonstrated. | FENG JingKai LIU JinGuo | 2021 | Science China(Technological Sciences)2021，64，6： | 3 |
| 3 | Construction of an artificial intelligence system in dermatology: effectiveness and consideration of Chinese Skin Image Database (CSID)显示文摘After more than 60 years of development,artificial intelligence(AI)has been widely used in various fields.Especially in recent years,with the development of deep learning,AI has made many remarkable achievements in the medical field.Dermatology,as a clinical discipline with morphology as its main feature,is particularly suitable for the development of AI.The rapid development of skin imaging technology has helped dermatologists to assist in the diagnosis of diseases and has greatly improved the accuracy of diagnosis.Skin imaging data have natural big data attributes,which is important for AI research.The establishment of the Chinese Skin Image Database(CSID)has solved many problems such as isolated data islands and inconsistent data quality.Based on the CSID,many pioneering achievements have been made in the research and development of AI-assisted decision-making software,the establishment of expert organizations,personnel training,scientific research,and so on.At present,there are still many problems with AI in the field of dermatology,such as clinical validation,medical device licensing,interdisciplinary,and standard formulation,which urgently need to be solved by joint efforts of all parties. | Chengxu Li Wenmin Fei Yang Han Xiaoli Ning Ziyi Wang Keke Li Ke Xue Jingkai Xu Ruixing Yu Rusong Meng Feng Xu Weimin Ma Yong Cui | 2021 | Intelligent Medicine2021，1，2： | 1 |
| 4 | Effect of Zn content on microstructure,mechanical properties and thermal conductivity of extruded Mg-Zn-Ca-Mn alloys显示文摘Mg-Zn-Ca-Mn series alloys are developed as promising candidates of 5G communication devices with excellent thermal conductivities,great ductility,and acceptable strength.In present paper,Mg-x Zn-0.4Ca-0.2Mn(x=2wt%,4wt%,6wt%)alloys were prepared by a near-solidus extrusion and the effect of Zn content on mechanical and thermal properties were investigated.The results showed that the addition of minor Ca led to the formation of Ca_(2)Mg_(6)Zn_(3) eutectic phase at grain boundaries.A type of bimodal microstructure occurred in the as-extruded alloys,where elongated coarse deformed grains were embedded in refined recrystallized grains matrix.Correspondingly,both yield strength and ductility of the alloys were significantly enhanced after extrusion due to the great grain refinement.Specially,higher Zn content led to the increment in yield strength and a slight reduction in elongation due to the larger fractions of second phase particles.The room temperature thermal conductivity of as-extruded alloys was also improved compared with that of as-cast counterparts.The increment of Zn content decreased the thermal conductivity of both as-cast and as-extruded alloys,which was due to the increased second phase fraction and solution atoms in the matrix,that hindering the motion of electrons.The as-extruded Mg-2Zn-0.4Ca-0.2Mn(wt%)alloy exhibited the highest elongation of 27.7% and thermal conductivity of 139.2 W/(m·K),combined with an acceptable ultimate tensile strength of 244.0 MPa.The present paper provides scientific guidance for the preparation of lightweight materials with high ductility and high thermal conductivity. | Bei Tang Jinlong Fu Jingkai Feng Xiting Zhong Yangyang Guo Haili Wang | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，12： | 0 |
| 5 | A conductive supramolecular hydrogel creates ideal endogenous niches to promote spinal cord injury repair显示文摘The current effective method for treatment of spinal cord injury(SCI)is to reconstruct the biological microenvironment by filling the injured cavity area and increasing neuronal differentiation of neural stem cells(NSCs)to repair SCI.However,the method is characterized by several challenges including irregular wounds,and mechanical and electrical mismatch of the material-tissue interface.In the current study,a unique and facile agarose/gelatin/polypyrrole(Aga/Gel/PPy,AGP3)hydrogel with similar conductivity and modulus as the spinal cord was developed by altering the concentration of Aga and PPy.The gelation occurred through non-covalent interactions,and the physically crosslinked features made the AGP3 hydrogels injectable.In vitro cultures showed that AGP3 hydrogel exhibited excellent biocompatibility,and promoted differentiation of NSCs toward neurons whereas it inhibited over-proliferation of astrocytes.The in vivo implanted AGP3 hydrogel completely covered the tissue defects and reduced injured cavity areas.In vivo studies further showed that the AGP3 hydrogel provided a biocompatible microenvironment for promoting endogenous neurogenesis rather than glial fibrosis formation,resulting in significant functional recovery.RNA sequencing analysis further indicated that AGP3 hydrogel significantly modulated expression of neurogenesis-related genes through intracellular Ca2+signaling cascades.Overall,this supramolecular strategy produces AGP3 hydrogel that can be used as favorable biomaterials for SCI repair by filling the cavity and imitating the physiological properties of the spinal cord. | Biao Yang Chengzhen Liang Di Chen Feng Cheng Yuang Zhang Shaoke Wang Jiawei Shu Xianpeng Huang Jingkai Wang Kaishun Xia Liwei Ying Kesi Shi Chenggui Wang Xuhua Wang Fangcai Li Qian Zhao Qixin Chen | 2022 | Bioactive Materials2022，7，9： | 0 |
| 6 | Synergistic enhancement effect of polydopamine-polyethyleneimine hybrid films for a visible-light photoelectrochemical biosensing interface显示文摘Photoelectrochemical(PEC)active interfaces exhibiting visible-light responses and good electron-transfer ca-pabilities are key to the development of PEC biosensors.In this study,bioinspired polydopamine(PDA)-polyethyleneimine(PEI)hybrid films were designed to engineer inorganic semiconductors and construct PEC biosensing interfaces.The charge-transfer capability and visible-light-response property of PDA were combined with the electron-attracting ability of PEI to produce a synergistic PEC-enhancement effect.The achieved PEC-enhancement effect was versatile for photoanode and photocathode semiconductors.Further,the role of PEI doping was revealed via electrochemical investigations.Compared with the PDA sensing platform,the hybrid sensing interface offered by the PDA-PEI film exhibited enhanced analytical performances toward ascorbic acid(AA),achieving a larger detection range and a lower limit of detection. | Jingkai Shan Wenhao Gao Xinyue Liu Jinhui Feng Li Dai Huan Wang Dawei Fan Hongmin Ma Qin Wei | 2023 | ChemPhysMater2023，2，1： | 0 |
| 7 | Microstructures,mechanical properties and degradability of Mg-2Gd-0.5(Cu/Ni)alloys:A comparison study显示文摘Low alloying Mg-2 Gd-0.5(Cu/Ni)alloys for sealing tools in the oil and gas industry were prepared.The differences in the effects of minor Cu and Ni additions on microstructures and properties of the Mg-2 Gd alloy were compared.The results showed that adding Ni was more effective than adding Cu in refining grain sizes,strengthening the basal fiber texture,and promoting the formation of LPSO phases,resulting in higher strength.The tensile yield strength/elongation of the Mg-2 Gd-0.5 Cu alloy,Mg-2 Gd-0.25 Cu-0.25 Ni alloy,and Mg-2 Gd-0.5 Ni alloy was 146 MPa/23.7%,175 MPa/23.1%,and 248 MPa/18.2%,respectively.The decreased elongation was attributed to the basal fiber texture and the presence of coarse LPSO phases.In terms of the corrosion rate in 3.5 wt.%NaCl solution,it rose from 112 mm y^(-1)for the Mg-2 Gd-0.5 Cu alloy to 269 mm y^(-1)for the Mg-2 Gd-0.25 Cu-0.25 Ni alloy and 490 mm y^(-1)for the Mg-2 Gd-0.5 Ni alloy,indicating that the addition of Ni instead of Cu showed a more significant promoting effect on the degradability of Mg alloys,which was related to more refined grains,the stronger basal fiber texture,and a larger amount of LPSO phases. | Shiyu Zhong Dingfei Zhang Yongqin Wang Sensen Chai Jingkai Feng Yulun Luo Jianrong Hua Qimin Dai Guangshan Hu Junyao Xu Bin Jiang Fusheng Pan | 2022 | Journal of Materials Science & Technology2022，，33： | 0 |
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