|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neuronal apoptosis in cerebral ischemia/reperfusion area following electrical stimulation of fastigial nucleus显示文摘Previous studies have indicated that electrical stimulation of the cerebellar fastigial nucleus in rats may reduce brain infarct size, increase the expression of Ku70 in cerebral ischemia/ reperfusion area, and decrease the number of apoptotic neurons. However, the anti-apoptotic mechanism of Ku70 remains unclear. In this study, fastigial nucleus stimulation was given to rats 24, 48, and 72 hours before cerebral ischemia/reperfusion injury. Results from the electrical stimulation group revealed that rats exhibited a reduction in brain infarct size, a significant increase in the expression of Ku70 in cerebral ischemia/reperfusion regions, and a decreased number of terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)-positive cells. Double immunofluorescence staining revealed no co-localization of Ku70 with TUNEL-positive cells. However, Ku70 partly co-localized with Bax protein in the cytoplasm of rats with cerebral ischemia/reperfusion injury. These findings suggest an involvement of Ku70 with Bax in the cytoplasm of rats exposed to electrical stimulation of the cerebellar fastigial nucleus, and may thus provide an understanding into the anti-apoptotic activity of Ku70 in cerebral ischemia/reperfusion injury. | Jingli Liu Jinpin Li Yi Yang Xiaoling Wang Zhaoxia Zhang Lei Zhang | 2014 | Neural Regeneration Research2014，9，7： | 26 |
| 2 | Parameterization of COSMO-RS model for ionic liquids显示文摘The adjustable parameters in the popular conductor-like screening model for real solvents(COSMO-RS)within the Amsterdam density functional(ADF)framework have been re-optimized to fit for the systems containing ionic liquids(ILs).To get the optimal values of misfit energy constant a^0,hydrogen bond coefficient c_(hb)and effective contact surface area of a segment a_(eff),2283 activity coefficient data points at infinite dilution and 1433 CO_2 solubility data points exhaustively collected from references were used as training set.The average relative deviations(ARDs)of activity coefficients at infinite dilution and CO_2 solubility between experimental data and predicted values are 32.22%and17.61%,respectively,both of which are significantly lower than the original COSMO-RS versions.Predictions for other activity coefficients of solutes in ILs,solubility data of CO_2 in pure ILs and the binary mixtures of ILs at either high or low temperatures,and vapor–liquid equilibrium(VLE)for binary systems involving ILs have also been performed to demonstrate the validity of the parameterization of COSMO-RS model for ILs.The results showed that the predicted results by COSMO-RS model with the new optimized parameters are in much better agreement with experimental data than those by the original versions over a wide temperature and pressure range.The COSMO-RS model for ILs presented in this work improves the prediction accuracy of thermodynamic properties for the systems containing ILs,which is always highly desirable for general chemical engineers. | Jingli Han Chengna Dai Gangqiang Yu Zhigang Lei | 2018 | Green Energy & Environment2018，3，3： | 6 |
| 3 | FURTHER RESULTS ON LIMITATIONS OF SAMPLED-DATA FEEDBACK显示文摘To control continuous-time uncertain dynamical systems with sampled data-feedback is prevalent today,but the sampling rate is usually not allowed to be arbitrarily fast due to various physical and/or computational constrains.In this paper,the authors examine the limitations of sampled-data feedback control for a class of uncertain systems in continuous-time,with sampling rate not necessary fast enough and with the unknown system structure confined to a set of functions with both linear and nonlinear growth.The limitations of the sampled-data feedback control for the uncertain systems are established quantitatively,which extends the existing related results in the literature. | REN Jingli CHENG Zhibo GUO Lei | 2014 | Journal of Systems Science & Complexity2014，27，5： | 4 |
| 4 | Solubility of CO2 inbinary mixtures of room-temperature ionic liquids at high pressures显示文摘 | Lei Zhigang Han Jingli Zhang Benfeng | 2012 | Chem Eng Data2012，57，8： | 1 |
| 5 | Interfacial charge effects of supported-metal-cluster heterostructures on azo hydrogenation catalyzation显示文摘The impact of interfacial charge on catalytic performance of supported-metal-cluster(SMC)heterostructures remains unclear,hindering efforts to develop high-performance SMC catalysts.Herein we systematically investigated interfacial charge effects of SMCs using a model system of graphene-supported gold-nanoclusters(AuNCs/rGO)for azo hydrogenation.Three types of SMCs with different interfacial charges were synthesized by anchoring electropositive 2-aminoethanethiol(CSH),amphoteric cysteine(Cys),and electronegative 3-mercaptopropionic-acid(MPA)onto AuNCs/rGO,respectively.All three SMCs exhibited high and selective catalytic activity to azo-hydrogenation in four representative azo dyes.The catalytic activity of Cys@AuNCs/rGO was lower than that of CSH@AuNCs/rGO but higher than that of MPA@AuNCs/rGO.However,the cyclic stability of Cys@AuNCs/rGO was inferior to that of both CSH@AuNCs/rGO and MPA@AuNCs/rGO.Further mechanistic studies revealed that amino ligands modified CSH@AuNCs and Cys@AuNCs agglomerated into large-size gold nanoparticles on rGO surface during catalytic reaction under NaBH_(4) action,leading to reduced efficiency and cyclic stability.Conversely,non-amino ligand modified MPA@AuNCs only partially detached from rGO surface without agglomeration,resulting in better cyclic stability.Protection of amino groups in ligands such as modifying-NH_(3)^(+)group in Cys into imine to form N-isobutyryl-L-cysteine(NIBC)substantially improved the cyclic stability while maintaining the high activity in the NIBC@AuNCs/rGO catalyst system.Our work provides an approach for developing a highly-active and stable SMC heterostructure catalyst via manipulating interfacial charges in SMC. | Zhenhua Gu Jingli Zhang Zijun Zhang Qingxue Mu Liangchong Yu Taolei Sun Lei Shen Guanbin Gao | 2024 | Nano Research2024，17，5： | 0 |
| 6 | Factors controlling the reservoir accumulation of Triassic Chang 6 Member in Jiyuan-Wuqi area,Ordos Basin,NW China显示文摘In the Triassic Yanchang Formation, Jiyuan-Wuqi area, Ordos Basin, the Chang 6 reservoir is contacted to the Chang 7 high-quality source rock, but the oil pools are unevenly distributed, and complex in oil and water distribution. Through cores observation and fracture statistics, combined with comprehensive analyses of physical property, mercury injection, logging and geochemical data, and comparisons of the sandbodies scales, reservoir physical properties, argillaceous laminae and fractures between source and reservoir in the eastern and western oil-bearing areas and in the central water producing area, it is found that the hydrocarbon accumulation patterns are different in the eastern, central and western areas, and the characteristics of hydrocarbon migration under the background of double-provenance were sorted out. The study results show that the crude oil in the eastern area has different Pr/Ph and sterane distribution from that in the western area. The oil and gas primarily migrated vertically. The high-quality source rocks and favorable source-reservoir-cap combinations lay the foundation for large-scale oil and gas accumulations. Vertically, the oil and gas enrichment is controlled by the scale of sandbody and the difference of physical properties, while on the plane, it is controlled by the connectivity of sandbodies, the argillaceous laminae between source rock and reservoir, the reservoir physical property and the fractures. The sandbodies of oil-rich zones in the eastern and western areas have large thickness, low shale content, good physical properties, weak heterogeneity, few argillaceous laminae and abundant fractures, all of which are favorable for the vertical migration and accumulation of oil and gas. In contrast, in the middle area with converging provenances, the reservoirs, composed of thin sandbodies, features rapid variation in lithology and physical properties, strong heterogeneity, poor continuity of sandbodies, abundant argillaceous laminae between source rock and reservoir, and few fractures, makes it difficult for the oil and gas to migrate vertically, and results in low oil enrichment degree ultimately. For the exploration of continental multiple-provenance tight reservoirs, not only the good-property source rocks and reservoirs, but more importantly the source-reservoir contact relationship and the effect of fractures on the hydrocarbon migration and accumulation should be considered. | CHEN Shijia LEI Junjie LIU Chun YAO Jingli LI Yong LI Shixiang SU Kaiming XIAO Zhenglu | 2019 | Petroleum Exploration and Development2019，46，2： | 0 |
| 7 | Mutational screening of affected cardiac tissues and peripheral blood cells identified novel somatic mutations in GATA4 in patients with ventricular septal defect显示文摘The aim of this study was to examine how somatic mutations of the GATA4 gene contributed to the genesis of ventricular septal defect (VSD). The coding and intron-exon boundary regions of GATA4 were sequenced of DNA samples from peripheral blood cells and cardiac tissues of twenty surgically treated probands with VSD. Seven novel heterozygous variants were detected in cardiac tissues from VSD patients, but they were not detected in the peripheral blood cells of VSD patients or in 500 healthy control samples. We replicated 14 single nucleotide polymorphisms (SNPs) reported in NCBI. Bioinformatics analysis was performed to analyze the possible mechanism by which mutations were linked to VSD. Among those variants, c. 1004C>A (p.S335X) occurred in the highly conserved domain of GATA4 and generated a termination codon, which led to the production of truncated GATA4. The seven novel heterozygous GATA4 mutations were only identified in cardiac tissues with VSD, suggesting that they are of somatic origin. A higher mutation rate in cardiac tissues than in peripheral blood cells implies that the genetic contribution to VSD may have been underestimated. | Chunyan Cheng Yuan Lin Fan Yang Wenjing Wang Chong Wu Jingli Qin Xiuqin Shao Lei Zhou | 2011 | The Journal of Biomedical Research2011，25，6： | 0 |
| 8 | Enhanced Plasmonic-Induced Absorption Using a Cascade Scheme and Its Application as Refractive-Index Sensor显示文摘In this paper,we describe a new method to improve fast-light transmission,which uses cascades.We design a simple plasmonic device that enables plasmonic-induced absorption(PIA).It consists mainly of two parallel rectangular cavities.The numerical results simulated by using the finite element method(FEM)confirm its function.The corresponding group delay-time can reach-0.146 ps for the PIA window.Based on this result,we propose a cascade device,with the dual-rectangular cavity system as building block,to improve fast-light transmission even more.The results indicate that the cascade scheme can increase the group delay-time to-0.456 ps,which means the fast-light feature is substantially enhanced compared with the non-cascading approach.The effect of the distance between two cascade resonators and other structural parameters is also investigated.Finally,we use this design concept to build a refractive-index sensor with a sensitivity of 701 nm/RIU. | Xinyi LI Daobin WANG Shoupeng WANG Lihua YUAN Jingli LEI Xiaoxiao LI | 2020 | Photonic Sensors2020，10，2： | 0 |
| 9 | Noninherited Factors in Fetal Congenital Heart Diseases Based on Bayesian Network:A Large Multicenter Study显示文摘Background:Current studies have confirmed that fetal congenital heart diseases(CHDs)are caused by various factors.However,the quantitative risk of CHD is not clear given the combined effects of multiple factors.Objective:This cross-sectional study aimed to detect associated factors of fetal CHD using a Bayesian network in a large sample and quantitatively analyze relative risk ratios(RRs).Methods:Pregnant women who underwent fetal echocardiography(N=16,086 including 3,312 with CHD fetuses)were analyzed.Twenty-six maternal and fetal factors were obtained.A Bayesian network is constructed based on all variables through structural learning and parameter learning methods to find the environmental factors that directly and indirectly associated with outcome,and the probability of fetal CHD in the two groups is predicted through a junction tree reasoning algorithm,so as to obtain RR for fetal CHD under different exposure factor combinations.Taking into account the effect of gestational week on the accuracy of model prediction,we conducted sensitivity analysis on gestational week groups.Results:The single-factor analysis showed that the RRs for the numbers of births,spontaneous abortions,and parental smoking were 1.50,1.38,and 1.11(P<0.001),respectively.The risk gradually increased with the synergistic effect of ranging from one to more environmental factors above.The risk was higher among subjects with five synergistic factors,including the number of births,upper respiratory tract infection during early pregnancy,anemia,and mental stress as well as a history of spontaneous abortions or parental smoking,than in those with less than 5 factors(RR=2.62 or 2.28,P<0.001).This result was consistent across the participants grouped by GWs.Conclusion:We identified six factors that were directly associated with fetal CHD.A higher number of these factors led to a higher risk of CHD.These findings suggest that it is important to strengthen healthcare and prenatal counseling for women with these factors. | Yanping Ruan Xiangyu Liu Haogang Zhu Yijie Lu Xiaowei Liu Jiancheng Han Lin Sun Ye Zhang Xiaoyan Gu Ying Zhao Lei Li Suzhen Ran Jingli Chen Qiong Yu Yan Xu Hongmei Xia Yihua He | 2021 | Congenital Heart Disease2021，16，6： | 0 |
| 10 | Aromatase and steroid sulfatase mRNA expression in fine needle aspirates from benign and malignant breast disorders显示文摘The fine needle aspiration (FNA) test is a convenient and tolerable technique with minimal invasion that is accepted by most women.Local estrogen synthesis depends mainly on the aromatase and steroid sulfatase pathways that are believed to play important roles in breast carcinogenesis.However,little is known about the level of aromatase and steroid sulfatase mRNA expression in FNA samples which contain only small amounts of tissue.The nested Q-PCR assay has been proven to be a highly sensitive and specific method to assess the aromatase expression of breast tissue.In this study,aromatase and steroid sulfatase mRNA expression in 74 patients with benign or malignant disorders was evaluated and compared using nested Q-PCR and non-nested Q-PCR assays.The expression levels were analyzed and correlated with clinical parameters.No difference in the aromatase expression levels between nested and non-nested Q-PCR was noticed.Age and aromatase mRNA expression level were two independent risk factors for breast cancer (P=0.04 and P=0.00,respectively),while menopausal status and steroid sulfatase mRNA expression levels were not associated with breast cancer.This study showed that both nested and non-nested Q-PCR assays were effective methods for research using FNA breast samples. | GAO Lei QI Ying LIU JingLi YU XiaoMeng XIA Wei LIU GuiJian | 2012 | Chinese Science Bulletin2012，57，20： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员