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| 1 | Pigsties near dwellings as a potential risk factor for the prevalence of Japanese encephalitis virus in adult in Shanxi,China显示文摘Background:The increasing trend of adult cases of Japanese encephalitis(JE)in China,particularly in northern China,has become an important public health issue.We conducted an epidemiological investigation in the south of Shanxi Province to examine the relationships between mosquitoes,Japanese encephalitis virus(JEV),and adult JE cases.Methods:Mosquito specimens were collected from the courtyards of farmers’households and pig farms in Shanxi Province.Mosquitoes were pooled,homogenized,and centrifuged.Reverse transcription-polymerase chain reaction(RT-PCR)was used to detect mosquito-borne arbovirus genes in homogenates.Specimens positive for these genes were inoculated into the baby hamster kidney cell line(BHK-21)to isolate virus.Minimum infection rate was calculated and phylogenetic analyses were performed.Results:A total of 7943 mosquitoes belonging to six species in four genera were collected;Culex tritaeniorhynchus accounted for 73.08%(5805/7943),C.pipiens pallens for 24.75%(1966/7943),and the remaining 3%(104/7943)consisted of Anopheles sinensis,Aedes vexans,Ae.dorsalis,and Armigeres subalbatus.Sixteen pools were positive for JEV based on RT-PCR using JEV pre-membrane gene nested primers.Phylogenetic analyses showed that all JEVs belonged to genotype I;two pools were positive using Getah Virus(GETV)gene primers.In addition,one JEV strain(SXYC1523)was isolated from C.pipiens pallens specimens.These results indicate that the minimum infection rate of JEV in mosquito specimens collected from the courtyards of farmers’households with pigsties was 7.39/1000;the rate for pig farms was 2.68/1000;and the rate for farmers’courtyards without pigsties was zero.Conclusions:The high-prevalence regions of adult JE investigated in this study are still the natural epidemic focus of JEV.Having pigsties near dwellings is a potential risk factor contributing to the prevalence of adult JE.To prevent the occurrence of local adult JE cases,a recommendation was raised that,besides continuing to implement the Expanded Program on Immunization for children,the government should urge local farmers to cease raising pigs in their own courtyards to reduce the probability of infection with JEV. | Xiaojie Ren Shihong Fu Peifang Dai Huanyu Wang Yuanyuan Li Xiaolong Li Wenwen Lei Xiaoyan Gao Ying He Zhi Lv Jingxia Cheng Guiqin Wang Guodong Liang | 2017 | Infectious Diseases of Poverty2017，6，1： | 6 |
| 2 | Regulation of EGF-induced ERK/MAPK Activation and EGFR Internalization by G Protein-coupled Receptor Kinase 2显示文摘G 联合蛋白质的受体家族 ases (GRK ) 调停各种各样的 G 联合蛋白质的受体(GPCR ) 的 agonist-inducedphosphorylation 和不敏感性。我们在表皮的生长上调查 GRK2 的角色因素( EGF )受体发信号,包括 EGF-inducedextracellular 调整信号的激酶和 激活mitogen 的蛋白激酶( ERK/MAPK ),激活 andEGFR internalization.Immunoprecipitation 和免疫荧光实验在人的胚胎的肾从细胞质显示出那 EGFstimulates GRK2 绑定到复杂的 EGFR 和 GRK2 translocating 到质膜 293 个房间。西方的弄污试金证明在时间的导致 EGF 的 ERK/MAPKphosphorylation 增加 1.9-fold,1.1-fold 和 1.5 褶层(P<0.05 ) 削尖 30,60,建议 GRK2 导致 onEGF 的 ERK/MAPK 激活的规章的角色并且 120min,分别地当房间是有 GRK2 的 transfected 时。流动 cytometry 实验证明然而,在表示上的 GRK2 没在导致 EGF 的 EGFR 成为主观上有效果它增加导致收缩筋的 G 联合蛋白质的 8opioid 受体成为主观约 40%(P<0.01 ) 。总的来说,这些数据建议那 GRK2has 在导致 EGF 的 ERK/MAPK 激活的一个规章的角色,并且在表明小径的 EGFR 和 GPCR 位于 GRK2 的调节角色下面的机制在受体成为主观至少是有点不同的。 | Jingxia GAO Jiali LI Lan MA | 2005 | Acta Biochimica et Biophysica Sinica2005，37，8： | 5 |
| 3 | Unexpected complexity of multidrug resistance in the mcr-1-harbouring Escherichia coli显示文摘Dear Editor,The discovery that the mobile colistin resistance gene(mcr-1)is encoded by plasmids and is prevalent in food animals and human beings worldwide(Hasman et al.,2015;Liu et al.,2015)has challenged greatly our traditional idea that polymyxin(consisting of two isoforms:polymyxin B and polymyxin E(colistin))acts as an ultimate line of refuge in the clinical treatment against the severe infections by the multidrug-resistant Gram-negative pathogens(Nation et al.,2015;Paterson and Harris,2015).To make | Rongsui Gao Yue Li Jingxia Lin Chen Tan Youjun Feng | 2016 | Science China(Life Sciences)2016，59，7： | 5 |
| 4 | A comprehensive review on natural phenolic compounds as alternatives to in-feed antibiotics显示文摘Intensive livestock and poultry farming in China largely relied on the use of in-feed antibiotics until July 2020.The consequences of antibiotic overuse in animal feed include accumulation in animal products and the development of bacterial antibiotic resistance,both of which threaten food safety and human health.China has now completely banned the circulation of commercial feed containing growth-promoting drug additives(except Chinese herbal medicine).Therefore,alternatives to in-feed antibiotics in animal production are greatly needed.Natural phenolic compounds(NPCs)exist widely in plants and are non-toxic,nonpolluting,highly reproducible,and leave little residue.Many natural flavonoids,phenolic acids,lignans,and stilbenes have polyphenol chemical structures and exhibit great potential as alternatives to antibiotics.In this review we delineate the characteristics of plant-derived NPCs and summarize their current applications as alternatives to in-feed antibiotics,aiming to provide new strategies for antibiotic-free feeding and promote the development of more sustainable animal husbandry practices. | Jingxia Gao Zhe Yang Chongqi Zhao Xiongzhuo Tang Qian Jiang Yulong Yin | 2023 | Science China(Life Sciences)2023，66，7： | 2 |
| 5 | Effects of ternary compound additives on densification and microstructure of alumina 显示文摘 | CHEN Changping GAO Jingxia YANG Huizhi | 2008 | Mater Sci Eng A2008，477，12： | 1 |
| 6 | Densification behavior and micro structural evolution of TiO2/CAS incor- porated alumina显示文摘 | Chen Changping Yang Huizhi Gao Jingxia | 2009 | Ceram Int2009，35，2： | 1 |
| 7 | RNA-seq reveals hormone-regulated synthesis of non-cellulose polysaccharides associated with fiber strength in a single-chromosomal-fragmentsubstituted upland cotton line显示文摘Cotton fibers are the main raw materials of the textile industry.Exogenous superior fiber genes have been introduced into upland cotton to develop high-yield cultivars with excellent fiber quality.We used a single chromosomal segment on the chromosome A07 substitution line SL7,with high fiber strength,to investigate the molecular mechanism underlying its fiber quality.RNA-seq and KEGG analysis showed that 70 differentially expressed genes were enriched in plant hormone transduction pathways,including auxin,ethylene and abscisic acid,in fibers at 10 days post-anthesis(DPA).Among these,fiberdevelopment related transcription factors MYB and NAC,including Gh_A11G0981(MYB108),Gh_A03G0887(NAC029),and Gh_A08G1691(NAC021),were significantly upregulated in SL7,as were numerous cellulose synthase-like(CSL)genes involved in non-cellulose polysaccharide and cell wall synthesis.The hemicellulose content of SL7 was significantly higher than that of L22,an upland cotton cultivar.These results suggest that key genes in the introgressed chromosomal segment of SL7 regulate the expression of transcription-factor genes via hormone-transduction pathways,thereby inducing the expression of genes involved in secondary wall synthesis and ultimately improving fiber quality.This study has shed light on the molecular mechanism of fiber development and will contribute to the improvement of fiber quality of upland cotton by molecular breeding. | Zhangqiang Song Yu Chen Chuanyun Zhang Jingxia Zhang Xuehan Huo Yang Gao Ao Pan Zhaohai Du Juan Zhou Yanxiu Zhao Zhi Liu Furong Wang Jun Zhang | 2020 | The Crop Journal2020，8，2： | 1 |
| 8 | Poly-dopamine, poly-levodopa, and poly-norepinephrine coatings: Comparison of physico-chemical and biological properties with focus on the application for blood-contacting devices显示文摘Thanks to its simplicity,versatility,and secondary reactivity,dopamine self-polymerized coatings(pDA)have been widely used in surface modification of biomaterials,but the limitation in secondary molecular grafting and the high roughness restrain their application in some special scenarios.Therefore,some other catecholamine coatings analog to pDA have attracted more and more attention,including the smoother poly-norepinephrine coating(pNE),and the poly-levodopa coating(pLD)containing additional carboxyl groups.However,the lack of a systematic comparison of the properties,especially the biological properties of the above three catecholamine coatings,makes it difficult to give a guiding opinion on the application scenarios of different coatings.Herein,we systematically studied the physical,chemical,and biological properties of the three catecholamine coatings,and explored the feasibility of their application for the modification of biomaterials,especially cardiovascular materials.Among them,the pDA coating was the roughest,with the largest amount of amino and phenolic hydroxyl groups for molecule grafting,and induced the strongest platelet adhesion and activation.The pLD coating was the thinnest and most hydrophilic but triggered the strongest inflammatory response.The pNE coating was the smoothest,with the best hemocompatibility and histocompatibility,and with the strongest cell selectivity of promoting the proliferation of endothelial cells while inhibiting the proliferation of smooth muscle cells.To sum up,the pNE coating may be a better choice for the surface modification of cardiovascular materials,especially those for vascular stents and grafts,but it is still not widely recognized. | Xing Tan Peng Gao Yalong Li Pengkai Qi Jingxia Liu Ru Shen Lianghui Wang Nan Huang Kaiqin Xiong Wenjie Tian Qiufen Tu | 2021 | Bioactive Materials2021，6，1： | 0 |
| 9 | Age-related changes in cerebral angiogenesis and fetal liver kinase-1 expression after cerebral ischemia/reperfusion显示文摘Cerebral angiogenesis in the early stages after cerebral ischemia injury is essential for the recovery of nerve function, in which fetal liver kinase-1 (Flk-1), as a major regulator of vasculogenesis and angiogenesis, plays a very important role. Microvessel density (MVD) was greater in an aged model group compared with the young sham operated group (P < 0.01). MVD and the sum of the lumen area were decreased in the aged group at 1, 3, 6 and 12 days following ischemia/reperfusion (I/R) injury compared with the young model group (P < 0.05 and P < 0.01, respectively). Flk-1 protein and mRNA expression was greater in the aged model group when compared with the young sham operated group (P < 0.01). Flk-1 protein and mRNA expression was lower in the aged group at 1, 3, 6 and 12 days after I/R compared with the young model group (P < 0.01). Flk-1 expression in aged rats attenuated rapidly, but was still maintained at relatively higher levels at 12 days following I/R in younger rats. The results suggest that angiogenesis was weakened after cerebral I/R in aged rats, and the mechanism of which might be correlated with attenuated expression of Flk-1 protein and mRNA. | Jiansheng Li Ke Liu Xinke Yang Jianfeng Gao Youlong Zhou Yuewu Zhao Zhengguo Liu Jingxia Liu | 2010 | Neural Regeneration Research2010，5，17： | 0 |
| 10 | Chlorophyll Content and Photosynthetic Characteristics of Pepper Inbred Lines显示文摘This study aimed to investigate chlorophyll content and photosynthetic characteristics of 17 pepper inbred lines which were selected independently. The results showed that chlorophyll contents significantly varied among different inbred lines. To be specific,chlorophyll content of No. 68 inbred line was significantly higher than that of other 14 inbred lines; chlorophyll content of No. 55 inbred line was significantly lower than that of other 15 inbred lines. The chlorophyll content of various inbred lines showed a decreasing order of No. 68 > No. 47 > No. 66 > No. 62 > No. 63 > No. 60 > No. 61 > No. 64 > No. 56 > No. 67 > No. 65 > No. 48 > No. 59 > No. 58 > No. 57 > No. 69 > No. 55; the photosynthetic rate of various inbred lines showed a decreasing order of No. 68 > No. 57 > No. 60 > No. 48 > No. 58 > No. 47 > No. 62 > No. 63 > No. 64 > No. 65; the maximum photosynthetic rate of No. 65 inbred line was significantly lower than other seven inbred lines,while no significant difference was observed among other nine inbred lines. | Xuemei WANG Jingxia GAO Shihong YANG Xiujuan YAN Shoucai MA Jingying CUI | 2013 | Agricultural Biotechnology2013，2，5： | 0 |
| 11 | Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury显示文摘Spinal cord injury(SCI) is a devastating traumatic injury that causes persistent, severe motor and sensory dysfunction. Immune responses are involved in functional recovery after SCI. Mucosa-associated lymphoid tissue lymphoma translocation 1(MALT1) has been shown to regulate the survival and differentiation of immune cells and to play a critical role in many diseases, but its function in lesion recovery after SCI remains unclear. In this paper, we generated KI(knock in) mice with a point mutation(C472 G) in the active center of MALT1 and found that the KI mice exhibited improved functional recovery after SCI.Fewer macrophages were recruited to the injury site in KI mice and these macrophages differentiated into anti-inflammatory macrophages. Moreover, macrophages from KI mice exhibited reduced phosphorylation of p65, which in turn resulted in decreased SOCS3 expression and increased pSTAT6 levels.Similar results were obtained upon inhibition of MALT1 paracaspase with the small molecule inhibitor‘‘MI-2' or the more specific inhibitor ‘‘MLT-827'. In patients with SCI, peripheral blood mononuclear cells(PBMC) displayed increased MALT1 paracaspase. Human macrophages showed reduced proinflammatory and increased anti-inflammatory characteristics following the inhibition of MALT1 paracaspase. These findings suggest that inhibition of MALT1 paracaspase activity in the clinic may improve lesion recovery in subjects with SCI. | Hua Zhang Guodong Sun Xiaowei Li Zhen Fu Chengbin Guo Guangchao Cao Baocheng Wang Qian Wang Shuxian Yang Dehai Li Xichun Xia Peng Li Jing Zhu Wei Zhou Liangyan Zheng Jingxia Li Lei Zhang Jianlei Hao Libing Zhou Frederic Bornancin Zhizhong Li Zhinan Yin Yunfei Gao | 2019 | Science Bulletin2019，64，16： | 0 |
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