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| 1 | Thermal fatigue behavior of K465 superalloy显示文摘The thermal fatigue behavior of K465 superalloy was investigated at the peak temperature of 1050°C. By scan-ning electron microscopy (SEM) and optical microscopy, the main crack length was observed and measured. The initiation sites of the tested alloys are different in as-cast (named as K465) and solution heat treatment (named as SK465) conditions. In K465 alloy, most thermal fatigue cracks nucleate at (Nb,W,Ti)C carbides. In SK465 alloy, thermal fatigue cracks initiate in interdendritic regions, MC-type carbides and some interfaces. Thermal fatigue cracks propagate in transdendritic mode, and M6C-type carbides could retard thermal fatigue crack growth for SK465 superalloy. | YANG Jinxia ZHENG Qi SUN Xiaofeng GUAN Hengrong HU Zhuangqi | 2006 | Rare Metals2006，25，3： | 15 |
| 2 | Tensile, creep behavior and microstructure evolution of an as-cast Ni-based K417G polycrystalline superalloy显示文摘The Ni-based K417 G superalloy is extensively applied as aeroengine components for its low cost and good mid-temperature(600–900?C) properties. Since used in as-cast state, the comprehensive understanding on its mechanical properties and microstructure evolution is necessary. In the present research,the tensile, creep behavior and microstructure evolution of the as-cast K417 G superalloy under different conditions were investigated. The results exhibit that tensile cracks tend to initiate at MC carbide and γ/γ' eutectic structure and then propagate along grain boundary. As the temperature for tensile tests increases from 21?C to 700?C, the yield strength and ultimate tensile strength of K417 G superalloy decreases slightly, while the elongation to failure decreases greatly because of the intermediate temperature embrittlement. When the temperature rises to 900?C, the yield strength and ultimate tensile strength would decrease significantly. The creep deformation mechanism varies under different testing conditions. At 760?C/645 MPa, the creep cracks initiate at MC carbides and γ/γ' eutectic structures,and propagate transgranularly. While at 900?C/315 MPa and 950?C/235 MPa, the creep cracks initiate at grain boundary and propagate intergranularly. As the creep condition changes from 760?C/645 MPa to 900?C/315 MPa and 950?C/235 MPa, the ? phase starts to raft, which reduces the creep deformation resistance and increases the steady-state deformation rate. | Beining Du Ziyang Hu Liyuan Sheng Chuanyong Cui Jinxia Yang Yufeng Zheng Xiaofeng Sun | 2018 | Journal of Materials Science & Technology2018，34，10： | 4 |
| 3 | Lacunar infarction with leukoaraiosis may aggravate cognitive dysfunction显示文摘This study semi-quantitatively analyzed the effects of leukoaraiosis.Patients with moderate or severe lacunar infarction were found to exhibit low scores on the Montreal Cognitive Assessment Scale (F=12.02,P=0.000),and prolonged P300 Cz2.0 latency (F=16.04,P=0.000).Correlation analysis revealed that the occurrence of leukoaraiosis was negatively correlated with Montreal Cognitive Assessment scores (r=-0.416,P=0.000),and positively correlated with P300 Cz2.0 latency (r=0.538,P=0.000).These findings indicate that leukoaraiosis aggravates cognitive impairment in patients with lacunar infarction,such that more severe leukoaraiosis is associated with more severe cognitive decline. | Dejin Sun Xueqin Zhang Penju Liu Jiechun Chen Jinxia Cao Aixia Zhuang Qinghong Zeng Shouqin Feng Yi Zhang Jiandong Jiang | 2011 | Neural Regeneration Research2011，6，31： | 3 |
| 4 | M5B3 Boride at the Grain Boundary of a Nickel-based Superalloy显示文摘The grain boundary microstructures of a heat-treated Ni-based cast superalloy IN792 were investigated. The results show that M_5B_3 boride precipitates at the grain boundary. A special orientation relationship between M_5B_3 phase and the matrix at one side of the grain boundary is found. At the same time, two M_5B_3 borides with different orientations could co-exist in a single M_5B_3 particle as an intergrowth besides existing alone, thus forming orientation relationship between the two M_5B_3 phases and matrix. This phenomenon could be attributed to the special orientation relationship between M_5B_3 phase and the matrix. | Beining Du Zhiwu Shi Jinxia Yang Zhaokuang Chu Chuanyong Cui Xiaofeng Sun Liyuan Sheng Yufeng Zheng | 2016 | Journal of Materials Science & Technology2016，32，3： | 2 |
| 5 | Ultrasound-induced biophysical effects in controlled drug delivery显示文摘Ultrasound is widely used in biomedical engineering and has applications in conventional diagnosis and drug delivery.Recent advances in ultrasound-induced drug delivery have been summarized previously in several reviews that have primarily focused on the fabrication of drug delivery carriers.This review discusses the mechanisms underlying ultrasound-induced drug delivery and factors affecting delivery efficiency,including the characteristics of drug delivery carriers and ultrasound parameters.Firstly,biophysical effects induced by ultrasound,namely thermal effects,cavitation effects,and acoustic radiation forces,are illustrated.Secondly,the use of these biophysical effects to enhance drug delivery by affecting drug carriers and corresponding tissues is clarified in detail.Thirdly,recent advances in ultrasound-triggered drug delivery are detailed.Safety issues and optimization strategies to improve therapeutic outcomes and reduce side effects are summarized.Finally,current progress and future directions are discussed. | Lulu Zhang Zhuohua Lin Lan Zeng Fan Zhang Lihong Sun Suhui Sun Ping Wang Menghong Xu Jinxia Zhang Xiaolong Liang Huiyu Ge | 2022 | Science China(Life Sciences)2022，65，5： | 2 |
| 6 | In Vivo Two-photon Calcium Imaging in Dendrites of Rabies Virus-labeled V1 Corticothalamic Neurons显示文摘Monitoring neuronal activity in vivo is critical to understanding the physiological or pathological functions of the brain.Two-photon Ca^(2+)imaging in vivo using a cranial window and specific neuronal labeling enables realtime,in situ,and long-term imaging of the living brain.Here,we constructed a recombinant rabies virus containing the Ca^(2+)indicator GCaMP6 s along with the fluorescent protein DsRed2 as a baseline reference to ensure GCaMP6 s signal reliability.This functional tracer was applied to retrogradely label specific V1-thalamus circuits and detect spontaneous Ca^(2+)activity in the dendrites of V1 corticothalamic neurons by in vivo two-photon Ca^(2+)imaging.Notably,we were able to record single-spine spontaneous Ca2+activity in specific circuits.Distinct spontaneous Ca^(2+)dynamics in dendrites of V1 corticothalamic neurons were found for different V1-thalamus circuits.Our method can be applied to monitor Ca^(2+)dynamics in specific input circuits in vivo,and contribute to functional studies of defined neural circuits and the dissection of functional circuit connections. | Yajie Tang Liang Li Leqiang Sun Jinsong Yu Zhe Hu Kaiqi Lian Gang Cao Jinxia Dai | 2020 | Neuroscience Bulletin2020，36，5： | 2 |
| 7 | Acetylation of rice straw with or without catalysts and its characterization as a natural sorbent in oil spill cleanup 显示文摘 | Sun Xiaofeng Sun Runcang Sun Jinxia | 2002 | J Agric Food Chem2002，50，22： | 1 |
| 8 | In vivo fiber photometry of neural activity in response to optogenetically manipulated inputs in freely moving mice显示文摘In vito fber photometry is a powerful technique to analyze the dy namics of population neurons during fiunctional study of neuroscience.Here,we introduced a detailed protocol for fiber photometry-based calciun reording in freely moving mice,covering from virus injection,fiber stub insertion,optogenetical stimulation to data procurement and analysis.Furthemnore,we applied this protocol to explore neuronal activity of mice latenal-posterior(LP)thalaric nucleus in response to optogenetical stimulation of primary visual cortex(V1)neurons,and explore axon clusters activity of optogenetically evoked V1 neurons.Final confirmation of virus-based protein expression in V1 and precise fber insertion indicated that the surgery procedure of this protocol is reliable for functional calcium recording.The scripts for data analysis and some tips in our protocol are provided in details.Together,this protocol is simple,low-cost,and effective for neuronal activity detection by fiber photometry,which will hep neuroscience researchers to carry out fiunctional and behavioral study in vivo. | Liang Li Yajie Tang Leqiang Sun Khaista Rahman Kai Huang Weize Xu Jinsong Yu Jinxia Dai Gang Cao | 2017 | Journal of Innovative Optical Health Sciences2017，，5： | 1 |
| 9 | Activation tagging, an efficient tool for functional analysis of the rice genome显示文摘 | Shuyan Wan Jinxia Wu Zhiguo Zhang Xuehui Sun Yaci Lv Ci Gao Yingda Ning Jun Ma Yupeng Guo Qian Zhang Xia Zheng Caiying Zhang Zhiying Ma Tiegang Lu | 2009 | Plant Molecular Biology (-)2009，，1： | 1 |
| 10 | Determination of cell wall ferulic and p-coumaric acids in sugarcane bagasse显示文摘 | FENG Xu SUN Runcang SUN Jinxia | 2005 | Analytica Chimica Acta2005，552，： | 1 |
| 11 | Effects of different C contents on the microstructure, tensile properties and stress-rupture properties of IN792 alloy显示文摘 | Jinxia Yang Qi Zheng Manqing Ji Xiaofeng Sun Zhuangqi Hu | 2010 | Materials Science & Engineering A2010，，3： | 1 |
| 12 | Determination of cell wall ferufic and p-coumaric acids in sugarcane bagasse显示文摘 | XU Feng SUN Runcang SUN Jinxia | 2005 | Analyfica Chimica Acta2005，552，： | 1 |
| 13 | Getting rid of NaBH4:Gold seeds reduced by air-stable agents for synthesizing quasi one-dimensional gold nanoparticles显示文摘Herein,we have presented a novel and easy to operate seed-mediated system for fabricating gold bipyramids(AuBPs)with 85%yields without any separation/purification processes.The used gold seeds are reduced by tannin and citrate,two kinds of air stable ligands,and conventio nally employed unstable NaBH4 are thoroughly cast off.In addition,the as-proposed gold seeds can also be employed for AuNRs fabrication with rather larger diameters(22.2-60.3 nm),which is difficult to be achieved by conve ntional seed mediated fabrication system. | Jinxia Sun Rong Luo Yunsheng Xia | 2020 | Chinese Chemical Letters2020，31，7： | 1 |
| 14 | Fractional extraction and structural characterization o{ sugarcane bagasse hemicelluloses显示文摘 | SUN Jinxia SUN Xiaofeng SUN Runcang | 2004 | Carbohydrate Polymers2004，56，2： | 1 |
| 15 | The compact Casπ(Cas12l)‘bracelet’provides a unique structural platform for DNA manipulation显示文摘CRISPR-Cas modules serve as the adaptive nucleic acid immune systems for prokaryotes,and provide versatile tools for nucleic acid manipulation in various organisms.Here,we discovered a new miniature type V system,CRISPR-Casπ(Cas12l)(~860 aa),from the environmental metagenome.Complexed with a large guide RNA(~170 nt)comprising the tracrRNA and crRNA,Casπ(Cas12l)recognizes a unique 5′C-rich PAM for DNA cleavage under a broad range of biochemical conditions,and generates gene editing in mammalian cells.Cryo-EM study reveals a‘bracelet’architecture of Casπeffector encircling the DNA target at 3.4Åresolution,substantially different from the canonical‘two-lobe’architectures of Cas12 and Cas9 nucleases.The large guide RNA serves as a‘two-arm’scaffold for effector assembly.Our study expands the knowledge of DNA targeting mechanisms by CRISPR effectors,and offers an efficient but compact platform for DNA manipulation. | Ao Sun Cheng-Ping Li Zhihang Chen Shouyue Zhang Dan-Yuan Li Yun Yang Long-Qi Li Yuqian Zhao Kaichen Wang Zhaofu Li Jinxia Liu Sitong Liu Jia Wang Jun-Jie Gogo Liu | 2023 | Cell Research2023，33，3： | 1 |
| 16 | Targeted drug delivery strategies for the treatment of rheumatoid arthritis显示文摘A chronic autoimmune disease named rheumatoid arthritis(RA)is characterized mainly by synovitis,which has high morbidity,disability and mortality rates.In addition,the aetiology and pathogenesis of RA have not been fully determined.RA is usually accompanied by persistent arthritic pain,swelling,stiffness,and functional disorders;in severe cases,it may result in cardiovascular,pulmonary,psychological and skeletal diseases(Scott et al.,2010). | Jinxia Zhang Ling Jiang Lihong Sun Ping Wang Suhui Sun Menghong Xu Lulu zhang Shumin Wang Xiaolong Liang Ligang Cui | 2021 | Science China(Life Sciences)2021，64，7： | 0 |
| 17 | IL-21 regulates macrophage activation in human monocytic THP-1-derived macrophages显示文摘Background:Interleukin-21(IL-21)has a regulatory effect on various immune cells.Its effect on macrophage function remains unclear.Aims:This study aimed to investigate the effect of IL-21 on the macrophagesmediated inflammatory response and explore its mechanism.Materials&Methods:Phorbol myristate acetate was used to induce THP-1-derived macrophages.Then,cells were stimulated with IL-21 and/or lipopolysaccharide(LPS).To determine the effect of IL-21 on the production of inflammatory factors in THP-1-derived macrophages,the messenger RNA(mRNA)and protein levels of IL-6,tumor necrosis factor-α(TNF-α),IL-8,and IL-10 were detected by real-time polymerase chain reaction(RT-PCR)and enzyme-linked immunosorbent assay(ELISA),respectively.Meanwhile,to explore the effect of IL-21 on macrophage polarization,macrophage phenotype,gene expression,and cytokine secretion mediated by THP-1-derived macrophage were detected by flow cytometry,RT-PCR,and ELISA.Results:First,we found that the IL-21 receptor was expressed in THP-1-derived macrophages.IL-21 enhanced LPS-mediated TNF-α,IL-6,and IL-10 production in THP-1-derived macrophages.During the polarization of THP-1-derived macrophages to M1-like macrophages,IL-21 induced the expression of macrophage surface markers CD86 and CD80,and related genes,such as TNF-α,IL-6,IL-1β,and DC-SIGN mRNA,inhibited Dectin-1 mRNA expression and promoted the secretion of TNF-α.During the polarization of THP-1-derived macrophages to M2-like macrophages,IL-21 enhanced the expression of macrophage surface markers CD86 and CD163,and related genes,such as TNF-α,IL-1β,IL-10,Dectin-1,and DC-SIGN mRNA,and promoted the secretion of IL-10.Conclusion:IL-21 promotes LPS-mediated production of inflammatory cytokines by THP-1-derived macrophages;IL-21 plays a two-way regulatory role in THP-1-derived macrophage polarization. | Leilei Jian Changhong Li Lin Sun Zhenzhen Ma Xinyu Wang Ruohan Yu Xiangyuan Liu Jinxia Zhao | 2021 | Rheumatology & Autoimmunity2021，1，1： | 0 |
| 18 | 11S蛋白酶体PSME3通过正反馈调节NF-κB信号通路调节机体抗菌反应与宿主防御显示文摘巨噬细胞在宿主防御以及机体内环境稳定的维持中发挥着至关重要的作用。当机体受到外来病原微生物入侵时,巨噬细胞能够通过分泌促炎因子和杀伤物质,杀死入侵的病原菌。然而,关于巨噬细胞在宿主防御过程中是如何被严格调控的,至今仍不是很清楚。 | Jinxia Sun Yi Luan Dong Xiang Xiao Tan Hui Chen Qi Deng Jiaojiao Zhang Minghui Chen Hongjun Huang Weichao Wang Tingting Niu Wenjie Li Hu Peng Shuangxi Li Lei Li Wenwen Tang 李晓涛 Dianqing Wu 王平 | 2017 | 科学新闻2017，19，4： | 0 |
| 19 | Effect of Zr and Ti on isothermal oxidation behavior of Nb–Si based alloys显示文摘The isothermal oxidation behavior of 56Nb-16Si-(20-x)Ti–3Cr–3Al-2Hf-xZr(x?0,2,5,10 at.%)alloys was investigated at 800℃ and 1250℃,respectively.The results show that increasing the Zr content evidently increased the oxidation rates at 800℃,accompanied by the obvious occurrence of pesting oxidation.The alloys showed alike linear oxidation kinetics at 1250℃.With the increase of Zr content,the adherence and integrity of oxide scales were improved,but the overall oxidation resistance was slightly deteriorated.The observed oxidation behavior may be attributed to the composition variation of Zr and Ti in the alloys.The oxidation mechanism associated with the composition variation is discussed in this study. | Ankang Sun Ziqiang Dong Shuang Yang Jintao Shu Yanjie Liu Yi Liu Yongwang Kang Dinggang Wang Jinxia Song | 2022 | Progress in Natural Science:Materials International2022，32，2： | 0 |
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