|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Development and application of genotyping technologies显示文摘With the completion of Human Genome Project,International HapMap Project and the publication of copy number variation in human genome,a great number of accurate,rapid,and cost-effective technologies for SNP analysis have been developed,promoting the research of the complex diseases.This article presents a review of widely used genotyping techniques,and the progress and prospect in the study of complex diseases in terms of the projects and achievements of Chinese National Human Genome Center at Shanghai(CHGCs). | SHI JinXiu,WANG Ying & HUANG Wei Shanghai-MOST Key Laboratory of Health and Disease Genomics,Chinese National Human Genome Center at Shanghai,Shanghai 201203,China | 2009 | Science China(Life Sciences)2009，52，1： | 6 |
| 2 | The dominant hepatitis B virus genotype identified in Tibet is a C/D hybrid显示文摘 | Chaoyin Cui Jinxiu Shi Lijian Hui Huifeng Xi Zhuoma Quni Tsedan and Gengxi Hu | 2002 | J Gen Virol2002，83，： | 1 |
| 3 | Fine genetic mapping of the chromosome 11q23.3 region in a Han Chinese population:insights into the apolipoprotein genes underlying the blood lipid-lipoprotein variances显示文摘The unusual chromosome 11q23.3 harboring the apolipoprotein(APO)gene cluster has been well documented for its essential roles in plasma lipid-related traits and atherosclerotic cardiovascular diseases.However,its genetic architecture and the potential biological mechanisms underlying complex phenotypes have not been well assessed.We conducted a study for this target region in a Han Chinese population through a stepwise forward framework based on massive parallel sequencing,association analyses,genetic fine mapping,and functional interpretation.The present study identified new meaningful genetic associations that were not simply determined by statistical significance.In addition to the APOA5 gene,we found robust evidence of the genetic commitments of APOC3 and APOA1 to blood lipids.Several variants with high confidence were prioritized along with the potential biological mechanism interpretations in the wake of adaptive fine-mapping analyses.rs2849174 in the APOC3 enhancer was discovered with an unrivaled posterior probability of causality for triglyceride levels and could mediate APOC3 expression through enhancer activity modulated by a combination of histone modifications and transcription factor accessibility.Similarly,multiple lines of evidence converged in favor of rs3741297 as a causal variant influencing high-density lipoprotein cholesterol.Our findings provided novel insights into this genomic locus in the Chinese population. | Weihua Shou Chenhui Zhang Jinxiu Shi Hong Wu Wei Huan | 2020 | Journal of Genetics and Genomics2020，47，12： | 1 |
| 4 | Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin显示文摘 | Shi Jinxiu Hui Lijian Xu Yonghai | 2002 | Human Mutation2002，19，4： | 1 |
| 5 | Association of Hemoglobin Levels, CYP3AS, and NRII3 Gene Polymorphisms with Tacrolimus Pharmacokinet- ics in Liver Transplant Patients, Drug Metab 显示文摘 | Dawei Chen Feng Guo Jinxiu Shi | 2014 | Pharmacokinet2014，29，3： | 1 |
| 6 | Browninginhibition on fresh-cut chestnut kernel by exogenousnitric oxide显示文摘 | Jingying Shi Jinxiu Li Shuhua Zhu | 2011 | International Journal of Food Science andTechnology2011，，46： | 1 |
| 7 | Non-noble-metal electrocatalysts for oxygen evolution reaction toward seawater splitting: A review显示文摘The direct electrolytic splitting of abundant seawater instead of scarce freshwater is an ideal strategy for producing clean and renewable hydrogen(H 2)fuels.The oxygen evolution reaction(OER)is a vital half-reaction that occurs during electrochemical seawater splitting.However,OER suffers from sluggish four-electron transfer kinetics and competitive chlorine evolution reactions in seawater.Noble metal-based catalysts such as IrO_(2) and RuO_(2) are considered to have state-of-the-art OER electrocatalytic activity,but the low reserves and high prices of these noble metals significantly limit their large-scale application.Recently,efforts have been made to explore efficient,robust,and anti-chlorine-corrosion non-noble-metal OER electrocatalysts for seawater splitting such as oxides,hydroxides,phosphides,nitrides,chalcogenides,alloys,and composites.An in-depth understanding of the fundamentals of seawater electrolysis and the design principle of electrode materials is important for promoting seawater-splitting technology.In this review,we first introduce fundamental reactions in seawater electrolytes.Subsequently,construction strategies for OER electrocatalysts for seawater splitting are introduced.Finally,present challenges and perspectives regarding non-noble-metal OER electrocatalysts for commercial H 2 production by seawater splitting are discussed. | Zhengguang Qin Wenxian Liu Wenbin Que Jinxiu Feng Wenhui Shi Fangfang Wu Xiehong Cao | 2023 | ChemPhysMater2023，2，3： | 0 |
| 8 | 三阴性乳腺癌基因组与转录组全景图:亚型及治疗策略显示文摘文章简介三阴性乳腺癌(triple-negative breast cancer,TNBC)是雌激素受体、孕激素受体和HER-2均为阴性的一群乳腺癌,缺乏有效靶向治疗,预后差,是乳腺癌学界的世界性难题。近年的研究表明TNBC是一个异质性很强的群体,为更全面而深入地认识这类疾病,寻找精准治疗的突破口,研究团队全面分析了465例原发性三阴性乳腺癌(TNBC)队列的临床、基因组学和转录组学数据。 | Yi-Zhou Jiang Ding Ma Chen Suo Jinxiu Shi Mengzhu Xue Xin Hu Yi Xiao Ke-Da Yu Yi-Rong Liu Ying Yu Yuanting Zheng Xiangnan Li Chenhui Zhang Pengchen Hu Jing Zhang Qi Hua Jiyang Zhang Wanwan Hou Luyao Ren Ding Bao Bingying Li Jingcheng Yang Ling Yao Wen-Jia Zuo Shen Zhao Yue Gong Yi-Xing Ren Ya-Xin Zhao Yun-Song Yang Zhenmin Niu Zhi-Gang Cao Daniel G.Stover Claire Verschraegen Virginia Kaklamani Anneleen Daemen John R.Benson Kazuaki Takabe Fan Bai Da-Qiang Li 王鹏 石乐明 黄薇 邵志敏 | 2020 | 科学新闻2020，，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员