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| 1 | Plant-derived exosome-like nanoparticles and their therapeutic activities显示文摘Nanotechnologies have been successfully applied to the treatment of various diseases.Plant-derived exosome-like nanoparticles (PENs) are expected to become effective therapeutic modalities for treating disease or in drug-delivery. PENs are minimally cytotoxic to healthy tissues, with which they show excellent biocompatibility, and are biased towards tumors by targeting specific tissues through special endocytosis mechanisms. Thus, the use of these PENs may expand the scope of drug therapies while reducing the off-target effects.In this review, we summarize the fundamental features and bioactivities of PENs extracted from the grape, grapefruit, ginger, lemon, and broccoli and discuss the applications of these particles as therapeutics and nanocarriers. | Jisu Kim Shiyi Li Shuya Zhang Jianxin Wang | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，1： | 4 |
| 2 | Endoplasmic reticulum stress controls m2macrophage differentiation and foam cell formation显示文摘 | Jisu Oh Riek AE | 2012 | J Biol Chem2012，287，11： | 1 |
| 3 | Phase separation and morphology control of polymer blend membranes of sulfonated and nonsulfonated polysulfones for direct methanol fuel cell application显示文摘 | Dong Hwee Kim Jisu Choi Young Taik Hong | 2007 | Journal of Membrane Science2007，299，1： | 1 |
| 4 | Active hepatitis B virus replication in the presence of anti-Hbe isassociated with viral Vavianta containing an inactive Pre-C vegion显示文摘 | Shuping T Jisu L Ludmila V | 1990 | Virology1990，176，： | 1 |
| 5 | 二氧化铈与氢气之间相互作用及其在炔烃选择加氢中的应用显示文摘二氧化铈因其具有较强的氧化还原性能和多变的酸碱功能而在催化领域有着广泛的应用,其可用作催化剂、改性剂或载体.虽然二氧化铈常被用于氧化反应,但由于其独特的选择性地将炔烃加氢成烯烃的能力,近年来引起了广泛的研究兴趣.氧化铈出色的加氢能力引发了新的研究热潮,以了解纯二氧化铈用作加氢催化剂的原理.本文综述了近年来氧化铈的实验和计算研究进展,重点介绍了氧化铈与氢气的相互作用和加氢反应.讨论了各种研究的重要观点,包括原位光谱/显微镜和铈在涉氢反应中的理论模型,从而阐明了氧化铈催化炔烃加氢反应能力的本质和反应机理.最后在总结和展望部分提出了进一步提高对铈基材料加氢反应机理认识和催化性能的途径. | James Kammert Jisue Moon Zili Wu | 2020 | Chinese Journal of Catalysis2020，41，6： | 1 |
| 6 | Selective and quantitative cell detection based both on aptamers and the conventional cell-staining methods显示文摘 | Jisu K GwanHo L Woong J | 2013 | Biosensors Bioelectr2013，43，： | 1 |
| 7 | Experi- mental Study on the Effect of N2, CO2, and Steam Dilu- tion on the Combustion Performance of H2 and CO Syn-thetic Gas in an Industrial Gas Turbine 显示文摘 | Min Chul Lee Seok Bin Seo Jisu Yoon | 2012 | Fuel2012，102，： | 1 |
| 8 | Isolation and expansion of synovial CD34?CD44+CD90+ mesenchymal stem cells: comparison of an enzymatic method and a direct explant technique显示文摘 | Dae-Hee Lee Seong-Dae Joo Seung-Beom Han Jisu Im Soon-Hyuck Lee Chung Hee Sonn Kyung-Mi Lee | 2011 | Connective Tissue Research2011，，3： | 1 |
| 9 | Phase separation and morphology control of polymer blend mem- branes of sulfonated and nonsulfonated polysulfones for direct methanol fuel cell application 显示文摘 | Dong Hwee Kim Jisu Choi Young Taik Hong | 2007 | Journal of Membrane Science2007，，299： | 1 |
| 10 | 1,25(OH)2Vitamin Dinhibits foam cell formation and suppresses macrophagecholesterol uptake in patients with type 2diabetes melli-tus显示文摘 | Jisu OH Weng S Shaili K | 2009 | Circulation2009，120，8： | 1 |
| 11 | Effect of Korean Magnolia obovata Extract on Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cells显示文摘Objective:To investigate the effects of Korean Magnolia obovata crude extract(KME)on plateletderived growth factor(PDGF)-BB-induced proliferation and migration of vascular smooth muscle cells(VSMCs).Methods:KME composition was analyzed by high-performance liquid chromatography(HPLC).VSMCs were isolated from the aorta of a Sprague-Dawley rat,incubated in serum free-Dulbecco's modified Eagle's medium in the presence or absence of KME(10,30,100,and 300(xg/mL),then further treated with PDGF-BB(10 ng/mL).VSMC proliferation was detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and VSMC migration was determined using the Boyden chamber and scratch wound healing assays.Western blot analysis was used to detect phosphorylation of extracellular signal-regulated protein kinases 1 and 2(p-ERK1/2),protein kinase B(p-Akt),and stress-activated protein kinase/c-Jun NH2-terminal kinase(p-SAPK/JNK).The antimigration and proliferation effects of KME were tested using aortic sprout outgrowth.Results:The HPLC analysis identified honokiol(0.45 mg/g)and magnolol(0.34 mg/g)as the major components of KME.KME(30,100,and 300μg/m L)significantly decreased the proliferation and migration of PDGF-BB-stimulated(10 ng/mL)VSMCs and the PDGF-BB-induced phosphorylation of EKR1/2,Akt,and SAPK/JNK(P<0.05).Furthermore,PDGF-BBinduced VSMCs treated with 300μg/m L of KME showed reduction in aortic sprout outgrowth.Conclusion:KME could inhibit abnormal proliferation and migration of VSMCs by down-regulating the phosphorylation of EKR1/2 and Akt.Thus,KME might be a functional food for preventing vascular disorders. | Hyunjhung Jhun Suji Baek Jinwoo Kim Kang-Pa Lee Hun-Young Park Won-Hwan Park Kiwon Lim Jisu Kim | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 1 |
| 12 | Sequence variation upstream of precore translation initiation codon reduces hepatitis B virus e antigen production显示文摘 | Sang Hoon Ahn Anna Kramvis Shigenobu Kawai Hans Christian Spangenberg Jisu Li Gerald Kimbi Michael Kew Jack Wands Shuping Tong | 2003 | Gastroenterology2003，，5： | 1 |
| 13 | 1,25(OH)2 Vitamin D Inhibits Foam Cell Formation and Suppresses Macrophage Cholesterol Uptake in Patients With Type 2 Diabetes Mellitus显示文摘 | Jisu Oh Sherry Weng Shaili K. Felton Sweety Bhandare Amy Riek Boyd Butler Brandon M. Proctor Marvin Petty Zhouji Chen Kenneth B. Schechtman Leon Bernal-Mizrachi Carlos Bernal-Mizrachi | 2009 | Circulation2009，，8： | 1 |
| 14 | Effect of seed layer prepared under various heating conditions on growth ofzno nanorod arrays for dye-sensitized solar ceils 显示文摘 | HYUKJAE L JUN-HO S JISU C | 2013 | Electron Mater Lett2013，9，3： | 1 |
| 15 | Effect of fuel-air mix- rare velocity on combustion instability of a model gas turbine combus- tor 显示文摘 | Jisu Yoon Min-Ki Kim Jeongjae Hwang | 2013 | Amplied Thermal Engineering2013，54，： | 1 |
| 16 | The role of histone modifications:from neurodevelopment to neurodiseases显示文摘Epigenetic regulatory mechanisms,including DNA methylation,histone modification,chromatin remodeling,and microRNA expression,play critical roles in cell differentiation and organ development through spatial and temporal gene regulation.Neurogenesis is a sophisticated and complex process by which neural stem cells differentiate into specialized brain cell types at specific times and regions of the brain.A growing body of evidence suggests that epigenetic mechanisms,such as histone modifications,allow the fine-tuning and coordination of spatiotemporal gene expressions during neurogenesis.Aberrant histone modifications contribute to the development of neurodegenerative and neuropsychiatric diseases.Herein,recent progress in understanding histone modifications in regulating embryonic and adult neurogenesis is comprehensively reviewed.The histone modifications implicated in neurodegenerative and neuropsychiatric diseases are also covered,and future directions in this area are provided. | Jisu Park Kyubin Lee Kyunghwan Kim Sun-Ju Yi | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 1 |
| 17 | Selective ischemic-hemisphere targeting Ginkgolide B liposomes with improved solubility and therapeutic efficacy for cerebral ischemia-reperfusion injury显示文摘Cerebral ischemia-reperfusion injury(CI/RI)remains the main cause of disability and death in stroke patients due to lack of effective therapeutic strategies.One of the main issues related to CI/RI treatment is the presence of the blood-brain barrier(BBB),which affects the intracerebral delivery of drugs.Ginkgolide B(GB),a major bioactive component in commercially available products of Ginkgo biloba,has been shown significance in CI/RI treatment by regulating inflammatory pathways,oxidative damage,and metabolic disturbance,and seems to be a candidate for stroke recovery.However,limited by its poor hydrophilicity and lipophilicity,the development of GB preparations with good solubility,stability,and the ability to cross the BBB remains a challenge.Herein,we propose a combinatorial strategy by conjugating GB with highly lipophilic docosahexaenoic acid(DHA)to obtain a covalent complex GB-DHA,which can not only enhance the pharmacological effect of GB,but can also be encapsulated in liposomes stably.The amount of finally constructed Lipo@GB-DHA targeting to ischemic hemisphere was validated 2.2 times that of free solution in middle cerebral artery occlusion(MCAO)rats.Compared to the marketed ginkgolide injection,Lipo@GB-DHA significantly reduced infarct volume with better neurobehavioral recovery in MCAO rats after being intravenously administered both at 2 h and 6 h post-reperfusion.Low levels of reactive oxygen species(ROS)and high neuron survival in vitro was maintained via Lipo@GB-DHA treatment,while microglia in the ischemic brain were polarized from the pro-inflammatory M1 phenotype to the tissue-repairing M2 phenotype,which modulate neuroinflammatory and angiogenesis.In addition,Lipo@GB-DHA inhibited neuronal apoptosis via regulating the apoptotic pathway and maintained homeostasis by activating the autophagy pathway.Thus,transforming GB into a lipophilic complex and loading it into liposomes provides a promising nanomedicine strategy with excellent CI/RI therapeutic efficacy and industrialization prospects. | Yang Li Miaomiao Zhang Shiyi Li Longlong Zhang Jisu Kim Qiujun Qiu Weigen Lu Jianxin Wang | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，2： | 1 |
| 18 | 好产品,可持续显示文摘2019年上映的科幻电影《流浪地球》中有这么一句经典台词:“最初,没有人在意这场灾难,这不过是一场山火,一次旱灾,一个物种的灭绝,一座城市的消失,直到这场灾难和每个人息息相关。”纵观近几年人类面临的种种灾难,如新冠肺炎疫情、澳洲森林火灾、东非蝗虫灾害、地震、海啸·时刻警醒人们要敬畏自然。低碳、新能源、新材料、被动式设计、绿色建筑、循环经济等概念已渗透进人们的生活,人类正以一系列可持续“行动”回应我们何以保护赖以生存的地球这一重要议题。 | Lisa Ogawa Tomomi Kawashima Aoyama Design Forum BuzziSpace Agustina Bottoni Marco Guazzini Natalia Criado Niva Design Marcel Wanders Ethimo MVRDV Delta Light Alexandre Joncas Gildas Le Bars d'Armes Lidia Covello OmniDecor Kiki van Eijk Joost van Bleiswijk Timo Ripatti Axolight Scott Richler Filippo Protasoni Fabbian Moreno Vannini Richard Bone Jisu Yun nendo Klaas Kuiken Charley Reijnders White Noise Dada Patricia Urquiola Cimento 郭映琴(编译) | 2022 | 现代装饰2022，，4： | 0 |
| 19 | Reflections on New Chinese Poetry显示文摘 | 王光明 Huang Jisu Su Xuetao | 2000 | Social Sciences in China2000，21，2： | 0 |
| 20 | High‑Defect‑Density Graphite for Superior‑Performance Aluminum‑Ion Batteries with Ultra‑Fast Charging and Stable Long Life显示文摘Rechargeable aluminum-ion batteries(AIBs)are a new generation of low-cost and large-scale electrical energy storage systems.However,AIBs suffer from a lack of reliable cathode materials with insufficient intercalation sites,poor ion-conducting channels,and poor diffusion dynamics of large chloroaluminate anions(AlCl4−and Al2Cl7−).To address these issues,surfacemodified graphitic carbon materials[i.e.,acidtreated expanded graphite(AEG)and base-etched graphite(BEG)]are developed as novel cathode materials for ultra-fast chargeable AIBs.AEG has more turbostratically ordered structure covered with abundant micro-to nano-sized pores on the surface structure and expanded interlayer distance(d002=0.3371 nm)realized by surface treatment of pristine graphite with acidic media,which can be accelerated the diffusion dynamics and efficient AlCl4−ions(de)-intercalation kinetics.The AIB system employing AEG exhibits a specific capacity of 88.6 mAh g^(−1)(4 A g^(−1))and~80 mAh g^(−1) at an ultra-high current rate of 10 A g^(−1)(~99.1%over 10,000 cycles).BEG treated with KOH solution possesses the turbostratically disordered structure with high density of defective sites and largely expanded d-spacing(d002=0.3384 nm)for attracting and uptaking more AlCl4−ions with relatively shorter penetration depth.Impressively,the AIB system based on the BEG cathode delivers a high specific capacity of 110 mAh g^(−1)(4 A g^(−1))and~91 mAh g^(−1)(~99.9%over 10,000 cycles at 10 A g^(−1)).Moreover,the BEG cell has high energy and power densities of 247 Wh kg^(−1) and 44.5 kW kg^(−1).This performance is one of the best among the AIB graphitic carbon materials reported for chloroaluminate anions storage performance.This finding provides great significance for the further development of rechargeable AIBs with high energy,high power density,and exceptionally long life. | Jisu Kim Michael Ruby Raj Gibaek Lee | 2021 | Nano-Micro Letters2021，13，11： | 0 |
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